Evanston, IL 60208-3108United States of Americahttp://www.nuance.northwestern.edu/biocryo/index.html
Last Updated: 10/01/2019
The integrated BioCryo Facility provides a comprehensive source for characterization of biological, soft matter, and hybrid samples with TEM (Transmission Electron Microscopy), SEM (Scanning Electron Microscopy), and STEM (Scanning Transmission Electron Microscopy) at cryogenic or at ambient temperature. We provide expertise and access to equipment for cryofixation and processing of frozen hydrated samples by high-pressure freezing, plunge freezing, freeze fracturing, cryo ultramicrotomy, freeze substitution, and turbo freeze-drying. Conventional samples can be processed at ambient temperature with chemical fixation, dehydration, and resin embedding, or critical point drying. We also offer EDX (Energy Dispersive X-ray Spectroscopy) for elemental analysis.
In addition to offering training on instruments and sample preparation techniques, BioCryo staff mentors new users, advises on experimental design, and collaborates with researchers in experiments with challenging and unconventional samples. Similar to other NUANCE facilities (EPIC, Keck-II, SPID), the BioCryo Facility participates in numerous educational and outreach events, e.g. workshops, seminars, demos, and facility tours.
We prepare samples for cryo and conventional electron microscopy, including plunge freezing, high-pressure freezing, freeze substitution and resin embedding.
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Consulting is offerred outside of Northwestern University
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