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Center for Macromolecular Interactions (Biophysics)

Harvard Medical School

240 Longwood Ave.

Building C, room 303

Boston, MA 02115

United States of America

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Primary Contact:

Kelly Arnett

Last Updated: 11/01/2022

Facility RRID


Facility Details

The Center for Macromolecular Interactions (CMI) in the department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School provides scientific consultation, training and access to shared biophysical equipment for the characterization and analysis of macromolecules and their complexes.

The facility offers training and access to instruments to measure molecular interactions by Isothermal Titration Calorimetry (ITC), Surface Plasmon Resonance (SPR), Biolayer Interferometry (BLI), MicroScale Thermophoresis (MST).

The facility also offers select data collection services, training and access on instruments to assess protein quality and biophysical properties by Differential Scanning Fluorimetry (DSF), Circular Dichroism (CD), Analytical Size Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS), Dynamic Light Scattering (DLS) and Mass Photometry (MP).

Using libraries developed in the lab of Andrew Kruse, the CMI is also offering yeast surface display nanobody selections services.

Facility Policies

Services are offerred outside of Harvard Medical School

Consulting is offerred outside of Harvard Medical School