The CoreMarketplace: Harvard Center for Biological Imaging (HCBI)

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Harvard Center for Biological Imaging (HCBI) (Microscopy (Electron, Fluorescence, Optical))

Facility Details

About This Facility

Services and Equipment

Publications

Awards & Associations

Metadata

Other Facilities at this Institution:

Bauer Core

HSPH Harvard Chan Bioinformatics Core

Mass Spectrometry and Proteomics Resource Laboratory

Harvard University

Room 2052 Biological Laboratories

16 Divinity Ave

Cambridge, MA 02138

United States

https://www.hcbi.fas.harvard.edu

cite this facility

Quicklinks:

https://coremarketplace.org/hcbi https://coremarketplace.org/RRID:SCR_018673

Primary Contact:

Douglas Richardson

Last Updated: 07/06/2022

Facility RRID

RRID:SCR_018673

Facility Details

The Harvard Center for Biological Imaging was opened May 17, 2010 and is one of the most innovative biological imaging centers in the world. In order to ensure investigators always have access to the latest and best technologies, the HCBI was designed to be an “Evergreen” microscopy facility. Imaging systems at the HCBI are leased rather than purchased and replaced every 2-3 years. This ensures that the facility remains relevant and is never in possession of outdated equipment. Currently, the HCBI contains 18 microscopes and high-end processing stations including confocal, super-resolution, multi-photon, lightsheet, live cell imaging, high-content screening, slide scanning, spatial transcriptomics, laser dissection and macroscopy. The facility also features wet lab space, eukaryotic and prokaryotic incubation, and access to nearby animal care facilities for a wide range of species.

Facility Policies

Services are offerred outside of Harvard University

Consulting is offerred outside of Harvard University

(To see more facility information, click the in the upper right)

Services offered:

Data Processing And Interpretation

High Content Screening

Laser Capture Microdissection

Microscopy

Multiphoton Microscopy

Optical Imaging

Slide Scanning

Whole Slide Imaging

Facility Equipment

https://hcbi.fas.harvard.edu/equipment

(To see more facility information, click the in the upper right)

Publications

Publications associated with this facility (Click To View):

1.) Han X, Lu X, Li PH, Wang S, Schalek R, Meirovitch Y, Lin Z, Adhinarta J, Murray KD, MacNiven LM, Berger DR, Wu Y, Fang T, Meral ES, Asraf S, Ploegh H, Pfister H, Wei D, Jain V, Trimmer JS, Lichtman JW (2024 Aug 5). Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex Nature Communications, 15(), 6648. . PMCID: 11300613.

2.) Noonan HR, Thornock AM, Barbano J, Xifaras ME, Baron CS, Yang S, Koczirka K, McConnell AM, Zon LI (2024 Jun 14). A chronic signaling TGFb zebrafish reporter identifies immune response in melanoma eLife, 13(), e83527. . PMCID: 11178360.

3.) Davis JC, Ryaboshapkina M, Kenty JH, Eser PÖ, Menon S, Tyrberg B, Melton DA (2024 Apr 11). IAPP Marks Mono-hormonal Stem-cell Derived β Cells that Maintain Stable Insulin Production in vitro and in vivo bioRxiv, (), 2024.04.10.587726. . PMCID: 11030367.

4.) Pearce S, Lin C, Pérez-Mercader J (2024 Feb 19). Adaptive and Dissipative Hierarchical Population Crowding of Synthetic Protocells through Click-PISA under Gradient Energy Inputs Nano Letters, 24(8), 2457-2464. . PMCID: 10906081.

5.) Lowet AS, Zheng Q, Meng M, Matias S, Drugowitsch J, Uchida N (2024 Jan 3). An opponent striatal circuit for distributional reinforcement learning bioRxiv, (), 2024.01.02.573966. . PMCID: 10802299.

6.) Zhang A, Zwang TJ, Lieber CM (2023 Nov 29). Biochemically functionalized probes for cell-type–specific targeting and recording in the brain Science Advances, 9(48), eadk1050. . PMCID: 10686571.

7.) Han X, Li PH, Wang S, Sanchez M, Aggarwal S, Blakely T, Schalek R, Meirovitch Y, Lin Z, Berger D, Wu Y, Aly F, Bay S, Delatour B, LaFaye P, Pfister H, Wei D, Jain V, Ploegh H, Lichtman J (2023 Nov 1). A large-scale volumetric correlated light and electron microscopy study localizes Alzheimer's disease-related molecules in the hippocampus. bioRxiv : the preprint server for biology, (), . . PMID: 37961104.

8.) Zhang A, Zwang TJ, Lieber CM (2023 Oct 3). Biochemically-functionalized probes for cell type-specific targeting and recording in the brain. bioRxiv : the preprint server for biology, (), . . PMID: 37873102.

9.) He LS, Qi Y, Allard CA, Valencia-Montoya WA, Krueger SP, Weir K, Seminara A, Bellono NW (2023 Sep 26). Molecular tuning of sea anemone stinging bioRxiv, (), 2023.06.15.545144. . PMCID: 10418081.

10.) Lafuente-Gómez N, de Lázaro I, Dhanjani M, García-Soriano D, Sobral MC, Salas G, Mooney DJ, Somoza Á (2023 Sep 24). Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model Materials Today Bio, 23(), 100817. . PMCID: 10562177.

11.) Han X, Lu X, Li PH, Wang S, Schalek R, Meirovitch Y, Lin Z, Adhinarta J, Berger D, Wu Y, Fang T, Meral ES, Asraf S, Ploegh H, Pfister H, Wei D, Jain V, Trimmer JS, Lichtman JW (2023 Jul 6). Multiplexed volumetric CLEM enabled by antibody derivatives provides new insights into the cytology of the mouse cerebellar cortex Research Square, (), rs.3.rs-3121892. . PMCID: 10350204.

12.) Tian H, Davis HC, Wong-Campos JD, Park P, Fan LZ, Gmeiner B, Begum S, Werley CA, Borja GB, Upadhyay H, Shah H, Jacques J, Qi Y, Parot V, Deisseroth K, Cohen AE (2023 Jul). Video-based pooled screening yields improved far-red genetically encoded voltage indicators. Nature methods, 20(7), 1082-1094. . PMID: 36624211.

13.) Spitzberg JD, Ferguson S, Yang KS, Peterson HM, Carlson JC, Weissleder R (2023 Mar 4). Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact Nature Communications, 14(), 1239. . PMCID: 9985597.

14.) Tian H, Davis HC, Wong-Campos JD, Park P, Fan LZ, Gmeiner B, Begum S, Werley CA, Borja GB, Upadhyay H, Shah H, Jacques J, Qi Y, Parot V, Deisseroth K, Cohen AE (2023 Jan 9). Video-based pooled screen yields improved far-red genetically encoded voltage indicators Nature methods, 20(7), 1082-1094. . PMCID: 10329731.

15.) Guerra San Juan I, Nash LA, Smith KS, Leyton-Jaimes MF, Qian M, Klim JR, Limone F, Dorr AB, Couto A, Pintacuda G, Joseph BJ, Whisenant DE, Noble C, Melnik V, Potter D, Holmes A, Burberry A, Verhage M, Eggan K (2022 May 18). Loss of mouse Stmn2 function causes motor neuropathy. Neuron, 110(10), 1671-1688.e6. . PMID: 35294901.

16.) Ghosh S, Leng W, Wilsch-Bräuninger M, Barrera-Velázquez M, Léopold P, Eaton S (2022 Apr 25). A local insulin reservoir in Drosophila alpha cell homologs ensures developmental progression under nutrient shortage. Current biology : CB, 32(8), 1788-1797.e5. doi: 10.1016/j.cub.2022.02.068. PMID: 35316653.

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Associations

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Metadata

Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=981
https://coremarketplace.org/RRID:SCR_018673

Institution

Institution ROR ID: https://ror.org/03vek6s52

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

USEDit, microscopy, cell imaging, confocal microscopy, consultation, data analysis, data processing, data interpretation, laser capture microdissection, microscopy, multiphoton microscopy, optical imaging, slide scanning, whole slide imaging, ABRF

Resource Type:

access service resource, service resource, core facility

Citation:

Harvard Center for Biological Imaging Core Facility (RRID:SCR_018673)

Harvard Center for Biological Imaging (HCBI) (Microscopy (Electron, Fluorescence, Optical))

Quicklinks:

Primary Contact:

Facility RRID

Facility Details

Facility Policies

(To see more facility information, click the in the upper right)

Services offered:

Facility Equipment

(To see more facility information, click the in the upper right)

Publications

(To see more facility information, click the in the upper right)

Associations

ABRF

NERLSCD

BINA

(To see more facility information, click the in the upper right)

Metadata

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Facility Profile QR Code (links to this profile)

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Harvard Center for Biological Imaging (HCBI)

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