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All Facilities >> University of Massachusetts Lowell >> UML - Microscopy Core Lab
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Olney Science Center
265 Riverside Street
Lowell, MA 01854
United Stateshttps://www.uml.edu/research/crf/ourlabs/microscopy-core-lab.aspxcite this facility
Last Updated: 05/19/2025
The Microscopy Core Laboratory (MCL) offers a variety of micro-imaging and micro-analysis solutions by providing access to several photon-, scanned probe-, ion beam-, and electron beam-based imaging and analytical instruments, services, and technical expertise for the characterization of materials including nano-engineered materials, microelectronics, photonics, biomaterials, and others with applications in life sciences, drug discovery, environmental and energy research. Consultative services are also available.
Services are offerred outside of University of Massachusetts Lowell
Consulting is offerred outside of University of Massachusetts Lowell
Jeol JEM-2100Plus Transmission Electron Microscope
Multipurpose transmissoin electron microscope ombining optic system of original JEM 2100 with advanced control system for enhanced ease of operation. [Product Link]
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Phillips CM12 Transmission Electron Microscope
General purpose analytical transmission/scanning transmission electron microscope (TEM/STEM). It was used to visualize the structure, chemical composition, and arrangement of atoms in thin, extraordinary small specimens. [Product Link]
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No additional equipment has been listed
No publications have been associated with this facility
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https://coremarketplace.org/?FacilityID=2540Institution
Institution ROR ID: https://ror.org/03hamhx47Keywords:
ABRF, micro-imaging, micro-analysis, characterization of materials, nano-engineered materials, microelectronics, photonics, biomaterials, imaging
Resource Type:
access service resource, core facility, service resource
Citation:
University of Massachusetts Lowell Microscopy Core Facility (RRID:SCR_024677)
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Judith Webber
https://cvvr.hms.harvard.edu/cvvr-research-program/#hiv-1-neutralizing-antibody-core
RRID:SCR_026484
Core provides in vitro HIV-1 neutralizing antibody assay services. Serves as resource for assessing breadth and potency of HIV-1 neutralizing antibodies, and for characterizing neutralization phenotype of HIV-1 isolates. Investigators send monoclonal antibodies or serum samples from vaccinated or HIV-1-infected individuals to the core for in vitro testing using the validated TZM.bl neutralizing antibody assay. The core also has the capability to phenotype primary HIV-1 isolates for sensitivity to broadly neutralizing antibodies. GCLP-compliant, In vitro testing of monoclonal antibodies or seurm samples, Validated TZM.bl neutralizing antibody assay, Phenotoyping of primary HIV-1 isolates.
This facility does not provide services outside its institution
This facility does not consult outside its institution
03/10/2025
Analysis Workstations
Cell Imaging
Confocal Microscope With FCS/FLIM Capabilities
Confocal Microscopy
Confocal/ Super Resolution Microscope
Consultations
Data Analysis
Data Processing And Interpretation
Differential Interference Contrast Microscopy
Fluorescence Lifetime
Fluorescence Lifetime Imaging
Fluorescence Microscope With Optical Sectioning Capability
Forster Resonance Energy Transfer (FRET)
Freeze Substitution
High Content Screening
Image Aquisition
Immunofluorescence
Immunohistochemistry
In-vivo Imaging
Laser Capture Microdissection
Laser Scanning
Light-sheet Microscopy
Live Cell Imaging
Microscopy
Multiphoton Microscopy
Multiphoton/ Harmonic Generation Microscope
Multiplex Fluorescence
Multiplexed Immunofluorescence
Optical Imaging
Phase Contrast Microscopy
Photomanipulation
Scanning 20X Brightfield
Scanning 20X Flourescent
Scanning 20X Fluorescent
Scanning 40X Brightfield
Scanning 40X Fluorescent
Single-molecule Imaging
Slide Scanning
Spinning Disk Confocal Imaging
STED Nanoscopy
Stereomicroscopy
Microscopy (Electron, Fluorescence, Optical)
Douglas Richardson
Room 2052 Biological Laboratories
16 Divinity Ave
Cambridge, MA 02138 - United States of America
RRID:SCR_018673
The Harvard Center for Biological Imaging was opened May 17, 2010 and is one of the most innovative biological imaging centers in the world. In order to ensure investigators always have access to the latest and best technologies, the HCBI was designed to be an “Evergreen” microscopy facility. Imaging systems at the HCBI are leased rather than purchased and replaced every 2-3 years. This ensures that the facility remains relevant and is never in possession of outdated equipment. Currently, the HCBI contains 20 microscopes and 12 high-end processing stations including confocal, super-resolution, multi-photon, lightsheet, live cell imaging, high-content screening, slide scanning, spatial transcriptomics, laser dissection and macroscopy. The facility also features wet lab space, eukaryotic and prokaryotic incubation, and access to nearby animal care facilities for a wide range of species.
This facility provides services outside its institution
This facility provides consulting outside its institution
09/30/2024
Bioinformatics
Maria Simoneau
401 Park Drive, 3rd Floor east
Boston, MA 02215 - United States of America
RRID:SCR_025373
We analyse all types of next-generation sequencing data from RNA-seq and single cell RNA-seq to variant sequencing (exome or whole genome), to ChIP-seq or bisulfite sequencing. We offer a dedicated bioinformatics training program for Harvard researchers interested in learning basic data skills and the analysis of high-throughput sequencing data. Our workshops focus on utilizing best practices in the field and research reproducibility.
This facility provides services outside its institution
This facility provides consulting outside its institution
05/21/2024
10x Genomics
Assays and Measurements
Cell Sorting
Consultation
Copy Number Variation (CNV)
Digital PCR
DNA Analysis
Droplet Digital PCR
FACS Cell Sorting
Flow Cytometric Analysis
Genomics
Genotyping
Microarray
Nanopore Sequencing
Nanostring
Nanostring NCounter
Nucleic Acid Extraction
Phosphor Imaging
Plate Reader
Real-time qPCR
RNA analysis
RNA Integrity
RNAseq
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Single-Cell Analysis
Single-cell Sequencing
Spectral Flow Cytometry
Genomics / Genome Analysis and Technologies
Claire Hartmann
52 Oxford St
Northwest Lab room B239
Cambridge, MA 02138 - United States of America
RRID:SCR_022656
Our goal is to advance research efforts in the life sciences that cannot readily be accomplished in the traditional academic laboratory because of a need for expensive instrumentation or automation, scientific or organizational infrastructure, or multidisciplinary expertise.
To promote cutting-edge research and to foster scientific collaborations, we make our extensive resources available to scientists at Harvard. Our technical staff provide expertise and hands-on training and the use of instrumentation for a nominal fee. Researchers can sign up to use the instrumentation through an on-line scheduling system and conduct their experiments independently.
This facility provides services outside its institution
This facility provides consulting outside its institution
08/08/2022
Data Analysis
Mass Spectrometry
Protein Extraction/Purification
Proteomics
Protocol Development/Clinical Trial Coordination
Sequencing - Protein Sequencing
Bogdan Budnik
52 Oxford Street
Northwest Labs B247
Cambridge, MA 02138 - United States of America
Proteomics and Mass Spectrometry Services, Quantitative Proteomics, LCMSMS, HPLC, C-terminal analysis, SILAC, FASP, MudPIT, GeLC, TMT quantitation and PTM analysis.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/01/2015
Central Laboratory Supply
Copy Number Variation (CNV)
DNA Analysis
Genomics
Genotyping
Library Services
Molecular Library Services
Nucleic Acid Extraction
oligo synthesis
PCR Arrays
Real-time qPCR
RNA analysis
RNA Integrity
Sequencing - Capillary Sequencing
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Shared Instrumentation Oversight & Maintenance
Genomics / Genome Analysis and Technologies
Robert Steen
NRB 088
77 Avenue Louis Pasteur
Boston, MA 02115 - United States of America
RRID:SCR_007175
-About the Core-
The BPF NGS Genomics Core Facility, formerly known as "The Biopolymers Facility," is a non-profit specialized service facility within the Department of Genetics at Harvard Medical School. The primary client base of the BPF consists of investigators at Harvard Medical School and affiliated research hospitals. While the majority of our users are located within the Longwood Medical Area, we also serve laboratories at schools, universities, and biotechnology companies globally.
Our mission is to provide investigators with access to technology services that will accelerate their research programs while simultaneously conserving time and resources by outsourcing laboratory experiments. Additionally, we offer a comprehensive range of popular reagents and supplies for immediate pickup from our Core Stock Room or Self-Service Supply Center. The core also provides cost-effective synthetic oligonucleotides and related products that are shipped directly to your laboratory through our IDT Portal. These resources facilitate the rapid development of research ideas into experiments while simultaneously reducing research expenditures through bulk pricing agreements and minimal, or no, shipping charges. We prioritize delivering high-quality data and expediting sample turnaround times.
Our comprehensive services encompass DNA and RNA Quality Assessment, Automation Services, Sanger DNA Sequencing, Next-Generation Library Preparation and Next-Generation Sequencing, Oligonucleotide Ordering, Reagent and Supplies Ordering, and training and access to a range of self-service instruments. We employ a comprehensive web-based Laboratory Information Management System (LIMS) to streamline ordering processes, monitor experiment progress, facilitate supply retrieval, grant data access, and facilitate invoice review and retrieval.
As a non-profit academic laboratory, we prioritize providing direct communication with our users regarding the processing of their samples. Our competitive pricing structure ensures that grant funds are allocated judiciously, aligning with the cost of experiments.
We offer complimentary consultations to facilitate discussions on collaboration opportunities, provide letters of support for funding proposals, and address inquiries about experimental design and the appropriate technologies and services to meet research requirements. Please do not hesitate to contact us at info@genome.med.harvard.edu for any inquiries.
This facility provides services outside its institution
This facility provides consulting outside its institution
02/12/2025
RRID:SCR_009798
Facility is small molecule and functional genomics high-throughput screening laboratory. It is built around modular work stations and most assays are performed in 384-well plates. There are over 500,000 small molecules available for screening at ICCB-Longwood and compound collection is continuously growing. Whole human and mouse genome siRNA libraries, arrayed sgRNA libraries, lncRNA siRNA libraries, as well as miRNA mimic and inhibitor libraries, are also available for screening. These libraries can be screened at the genome level or in focused subsets.
This facility does not provide services outside its institution
This facility does not consult outside its institution
12/10/2024
Critical Point Drying
Cryo-Ultra Microtomy
Freeze Substitution
High Pressure Freezing
Immuno Electron Microscopy
Microtomy/Electron
Negative Staining For TEM
Sample Preparation
Scanning Electron Microscopy
Sputter Coating
Transmission Electron Microscopy
Microscopy (Electron, Fluorescence, Optical)
220 Longwood Avenue
Boston, MA 02115 - United States
RRID:SCR_009793
The HMS Electron Microscopy Facility makes high quality electron microscopy services, instrumentation and training easily accessible to all researchers. Our services include consultation and experimental design for a wide variety of biological samples for both SEM and TEM.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/10/2024
Imaging (Cell, Molecular, PET, Translational)
RRID:SCR_009808
Open access light microscopy and tissue core located within Neurobiology Department.
Provides services in optical imaging, tissue clearing, in situ hybridization as well as introduces new equipment and cutting technology to the basic science community. Provides expertise, equipment, services and learning opportunities to researchers in the greater Boston area.
This facility does not provide services outside its institution
This facility does not consult outside its institution
10/04/2024
Transcriptomics
RRID:SCR_025837
Core specializes in single cell and spatial transcriptomics, and multiomics. Provides custom services, education, training and expertise in multiple high-throughput single cell technologies.
This facility does not provide services outside its institution
This facility does not consult outside its institution
10/04/2024
Transcriptomics
RRID:SCR_025844
Core specializes in analysis of nascent transcriptome using PRO-seq and TT-seq NGS methods. Provides services allowing users to submit prepared cells and receive analyzed data. Offers free consultations to help with experimental design, answer questions, and discuss data analysis.
This facility does not provide services outside its institution
This facility does not consult outside its institution
10/04/2024
Animal Behavior
RRID:SCR_025842
The Mouse Behavior Core (MBC) offers a wide range of mouse behavioral equipment and assays to test a motor, cognitive, and affective behaviors. Trained users have access to eight behavioral testing rooms and a procedure room. The MBC staff offers consultation, training, and guidance in execution and interpretation of assays.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/02/2024
Microscopy (Electron, Fluorescence, Optical)
250 Longwood Ave, Boston MA 02115
Seeley G. Mudd B04
Boston, MA 02115
RRID:SCR_025841
The Harvard Cryo-Electron Microscopy Center for Structural Biology is a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital to provide state-of-the-art cryo-EM instrumentation and expertise for the Harvard structural biology community. This user facility offers consultation and training by staff in specimen preparation, microscope operation, image acquisition, and data analysis.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/02/2024
Biolayer Interferometry (BLI)
Circular Dichroism (CD)
Differential Scanning Fluorimetry (DSF)
Isothermal Titration Calorimetry (ITC)
Light Scattering
Mass Photometry
MicroScale Thermophoresis (MST)
Surface Plasmon Resonance (SPR)
Biophysics
Kelly Arnett
240 Longwood Ave.
Building C, room 303
Boston, MA 02115 - United States of America
RRID:SCR_018270
The Center for Macromolecular Interactions (CMI) in the department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School provides scientific consultation, training and access to shared biophysical equipment for the characterization and analysis of macromolecules and their complexes.
The facility offers training and access to instruments to measure molecular interactions by Isothermal Titration Calorimetry (ITC), Surface Plasmon Resonance (SPR), Biolayer Interferometry (BLI), MicroScale Thermophoresis (MST).
The facility also offers select data collection services, training and access on instruments to assess protein quality and biophysical properties by Differential Scanning Fluorimetry (DSF), Circular Dichroism (CD), Analytical Size Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS), Dynamic Light Scattering (DLS) and Mass Photometry (MP).
Using libraries developed in the lab of Andrew Kruse, the CMI is also offering yeast surface display nanobody selections services.
This facility provides services outside its institution
This facility provides consulting outside its institution
05/03/2024
Cell Imaging
Confocal Microscopy
Microscopy
Multiphoton Microscopy
Optical Imaging
Microscopy (Electron, Fluorescence, Optical)
Harry Leung
200 Longwood Ave
Boston, MA 02115 - United States
https://childrenshospital.corefacilities.org/service_center/show_external/3145
RRID:SCR_018822
confocal/multiphoton microscopy/electron microscopy/image analysis
This facility provides services outside its institution
This facility provides consulting outside its institution
05/01/2024
Fragment-based Drug Discovery
Fragment-based Screening
Metabolomics
Natural Product Analysis
NMR Medicinal Chemistry Support
NMR Quality Control For Biologic Drugs
NMR Quality Control For Biosimilars
Nuclear Magnetic Resonance (NMR)
Protein NMR
Structure Determination
Nuclear Magnetic Resonance
Gregory Heffron
Bio-NMR Core, Harvard Medical School
200 Longwood Avenue
Boston, MA 02115 - United States of America
RRID:SCR_022967
State-of-the-art resource for NMR that offers services in fragment-based screening and drug discovery, characterization and QC of biologics and biosimilar drugs, metabolomics, protein NMR, small molecule NMR, and NMR of natural products. The facility offers 400-700MHz systems, many with cryogenic probes. The staff is highly experienced and dedicated.
This facility provides services outside its institution
This facility provides consulting outside its institution
11/14/2022
CRISPR Injection Services
Embryo Cryopreservation & Recovery Services
ES Cell Electroporation
ES Cell Injection
ES Cell Technology (Mouse)
Fresh/Frozen Sperm IVF
Injection Of DNA Constructs
Sperm Cryopreservation
Tail Biopsy
Transgenics
Michael Peluso
77 Avenue Louis Pasteur
NRB 837
Boston, MA 02115 - United States
https://www.dfhcc.harvard.edu/research/core-facilities/mouse-engineering/
RRID:SCR_022950
The Mouse Engineering Core was established in 1992 operating at the BWH, and is now located at Harvard Medical School. The Mouse Engineering Core provides services for the generation of transgenic and knockout mice using state-of-the-art facilities and equipment.
The Core has all of the equipment necessary for generation of transgenic mice including a Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation and transfer, a sutter needle puller and a de Fonbrune microforge. The facility maintains mice necessary for egg donors, egg recipients, and vasectomized males.
ES cell culture services have been offered for 15 years. The core offers electroporation of targeting vectors into ES cells and provides investigators with DNA to identify ES cells carrying the desired recombination events; and ES cell expansion for microinjection into blastocysts.
The core\'s newest services include CRISPR injections, sperm and embryo cryopreservation, and reanimation with fresh or frozen sperm via IVF or the thawing and implanting embryos.
This facility provides services outside its institution
This facility does not consult outside its institution
11/07/2022
Computational - High Performance Computing
Computational - Interactive Compute/storage
High Performance Computing
Neil Coplan
401 Park Drive
Boston, MA 02115 - United States
RRID:SCR_022289
The Research Computing Core is a set of research computing services provided by the Department of Information Technology at Harvard Medical School. The facilities include a high performance computing environment, O2, computational storage, and other services that support biomedical research such as research software licensing. Our services are only available to Harvard Medical School, Harvard University, and HMS Affiliates https://hms.harvard.edu/about-hms/hms-affiliates.
This facility provides services outside its institution
This facility does not consult outside its institution
05/17/2022
3D &
4D Image Processing Stations
3D Visualization
Cell Imaging
Clinical Imaging - Small Animal (luminescence/fluorescence)
Confocal Microscope With FCS/FLIM Capabilities
Confocal Microscopy
Confocal/ Super Resolution Microscope
Consultation
Data Analysis And Interpretation
Data Processing
Data Visualization
Deconvolution
Fluorescence Lifetime
Fluorescence Microscope With Optical Sectioning Capability
Image Aquisition
Immunofluorescence
In-vivo Imaging
Live Cell Imaging
Microscopy
Multiphoton Microscopy
Multiphoton/ Harmonic Generation Microscope
Optical Imaging
Spatial Transcriptomics
Super-resolution Microscopy
TIRF Microscopy
Training
Whole Slide Imaging
Widefield Microscopy
Paula Montero Llopis
77 Avenue Louis Pasteur NRB1032 A
Boston, MA 02115 - United States
RRID:SCR_022209
The Microscopy Resources On the North Quad (MicRoN) facility is a light microscopy core established by the Departments of Genetics, Immunology and Microbiology, and it is open to all HMS researchers, including Affiliated hospitals. MicRoN is a non-traditional decentralized or "floating" microscopy core. We support a wide range of imaging modalities ranging from widefield, TIRF, spinning disk and single point scanning confocal, multiphoton, FLIM and supper-resolution. The 14 microscopes that currently make up the core are embedded within the Departments of Microbiology, Immunology, and Genetics, housed in five microscope rooms on five floors of NRB and HIM. We find that this model generates a greater interaction among trainees from the three departments and encourages a more collaborative environment. We are proud of working with the Departments of Genetics, Microbiology and Immunology and would love hearing from you!
This facility provides services outside its institution
This facility provides consulting outside its institution
04/26/2022
Genotyping
Library Services
Microarray
BUSM
72 E. Concord, E605
Boston, MA 024118 - United States of America
RRID:SCR_017782
Currently, we provide analysis of gene expression using the Affymetrix GeneChip platform. Services using the Illumina platform will be available soon. For more information go to the services section of our website. For both platforms users of the facility provide us with high quality samples and the Microarray Resource does the rest. We also offer analysis of RNA, DNA and Proteins using Agilent Bioanalyzer.
We offer the same services to researchers outside of Boston University on an available-resource basis.
All interested researchers are encouraged to contact the Microarray Resource to discuss potential projects or to ask any question about the use of microarrays. Dr. Alekseyev can provide advice on experimental design, RNA isolation methods, and just about any aspect of array hybridization. Dr. Lenburg can provide advice on experimental design and data analysis.
Please note that we were able to reduce our pricing starting 12/16/2010.
This facility provides services outside its institution
This facility does not consult outside its institution
02/21/2011
Cryo-Electron Microscopy
Cryo-Electron Tomography
Immuno Electron Microscopy
Transmission Electron Microscopy
Microscopy (Electron, Fluorescence, Optical)
Berith Isaac
415 South St
Waltham, MA 02453
https://www.brandeis.edu/science/resources/electron-microscope/index.html
RRID:SCR_026272
The Brandeis EM facility offers wide variety of preparation and visualization ranging from standard 2D EM methods to high resolution 3D cryo-EM.
Instruments, training and assisted use are available for Brandeis faculty, staff, and lab members, as well as members of the broader scientific community, including other academic institutions and for-profit organizations.
This facility provides services outside its institution
This facility provides consulting outside its institution
05/05/2025
Andrew Stone
415 South Street
Bassine Building
Waltham, MA 02453 - United States
https://www.brandeis.edu/science/resources/light-microscopy/index.html
RRID:SCR_025892
The LMCF houses 13 high-end light microscopes including point scanning and spinning disk confocals, Airyscan, 3D-STED super resolution, widefield and TIRF systems. We offer training, consultation and access to powerful analysis computers with licensed softwares. We are open to external users from both academia and industry at competitive rates.
This facility provides services outside its institution
This facility provides consulting outside its institution
04/16/2025
Bioluminsecence Imaging
Clinical Imaging - Small Animal (luminescence/fluorescence)
Clinical Imaging - Small Animal (X-ray, Ultrasound, MicroCAT, MRI)
Gamma Counting
Image Analysis
Image Processing And Analysis
In Vivo Drug Evaluation
Machine Learning
Magnetic Resonance Imaging (MRI)
MicroCT
Positron Emission Tomography (PET)
Radioligant Therapy / Nuclear Theranostics
Imaging (Cell, Molecular, PET, Translational)
RRID:SCR_026699
Preclinical I&T’s mission is to assist the biomedical research community in evaluating disease and therapy within a complete biological system in-vivo. To do so, we focus on the use of minimally invasive and humane tools, with a strong focus in visualization and computation. Pharmacokinetic, pharmacodynamic, toxicity and dosing estimations can be performed with a variety of Preclinical I&T’s multi-modal services and technologies such as:
Digital imaging study design
Execution of pilot studies and preclinical trials
Optical Imaging: Fluorescence and Bioluminescence
Positron Emission Tomography (PET)
Radiotheranostics (Radioligand Therapy)
Quantitative gamma counting
Micro Computerized X-ray Tomography (microCT)
Ultrasound and Photoacoustic Imaging (USPA)
Magnetic Resonance Imaging (MRI)
Cryo-Fluorescence Tomography (CFT)
Image analysis workstations
Specialized data and imaging analysis workflows and software tool development
For more details please refer to the facility’s website: https://preclinical-imaging.mit.edu and https://ki-sbc.mit.edu/preclinical-imaging-testing
This facility provides services outside its institution
This facility provides consulting outside its institution
04/01/2025
10x Genomics
Computational - Bioinformatics
Copy Number Variation (CNV)
Data Analysis
Data Processing And Interpretation
DNA Analysis
Genomics
Library Services
Microbiome
oligo synthesis
Real-time qPCR
RNA analysis
RNA Integrity
Seq-Well
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Single-cell Sequencing
Genomics / Genome Analysis and Technologies
Stuart Levine
31 Ames St. 68-316
Cambridge, MA 02139 - United States of America
RRID:SCR_026413
The BioMicro Center is an integrated genomics/bioinformatics facility located at MIT. The core supports sample isolation, library preparation, short and long read sequencing, single cell and spatial analysis, bioinformatics, and data management.
This facility provides services outside its institution
This facility does not consult outside its institution
02/13/2025
3D Visualization
Atomic Force Spectroscopy
Confocal Microscopy
Cryo-Electron Microscopy
Electron Microscopy
Freeze Substitution
High-Pressure Freezing
Immuno Electron Microscopy
Light Scattering
Microscopy
Rheology
Abigail Lytton-Jean
500 Main Street
Room 76-037
Cambridge, MA 02139 - United States of America
RRID:SCR_018674
Other CIDs:2P30CA014051-39
P30-CA14051
We provide services and instrumentation for imaging and characterization of bio- and nanomaterials with a strong focus on biological sample preparation. Some instruments are available for independent use. We also provide full service TEM, cryoTEM, SEM/FIB and cryoSEM/FIB, cryoFluorscence, sample preparation and imaging. Additionally, we conduct CLEM and cryoCLEM workflows utilizing cryoFluorescence, cryoSEM and cryoFIB with a focus on bio samples. In some cases the endpoint imaging is in the SEM/FIB (2D or 3D volumeEM). In other instances samples are transferred to one of a selection of cryoTEMs. We also provide immunoEM. In addition to imaging services we provide training on instruments for independent user access to: SEM, TEM, rheometer, AFM, DLS, and Spectradyne (counting & sizing nanoparticles). Our instruments and services are available to both non-profit and for-profit entities.
This facility provides services outside its institution
This facility provides consulting outside its institution
02/12/2025
RRID:SCR_026340
Core offers automation and screening capabilities. Equipped with environmentally-controlled high-content microscopes, automated liquid handlers, plate washers and readers, and robotic platforms, HTS aims to accelerate experiments from small-scale assays to large screening campaigns.
This facility does not provide services outside its institution
This facility does not consult outside its institution
01/27/2025
Histology
Immunohistochemistry
Whole Slide Imaging
Histology
Kathy Cormier
500 Main St
76-182
Cambridge, MA 02139 - United States of America
RRID:SCR_019177
The Histology Core at KI-MIT processes a large variety of large and small animal tissues for paraffin/frozen sectioning and IHC. We also work up a large variety of samples with drug delivery devices and soft tissue constructs.
This facility provides services outside its institution
This facility does not consult outside its institution
11/10/2020
Cell Sorting
Flow Cytometric Analysis
Flow Cytometry
Glenn Paradis
76-279
500 Main Street
Cambridge, MA 02139 - United States of America
RRID:SCR_017892
This Core Facility provides MIT and Boston area researchers with technical expertise, training and access to sophisticated instrumentation, enabling and supporting the use of a wide range of flow cytometry techniques. This technology allows simultaneous multiparametric analysis of many thousands of cells per second, enabling trained researchers to rapidly analyze complex cell populations using benchtop analysis flow cytometers. High-speed assisted cell sorting services provide researchers with fast, objective and quantitative recording of fluorescent signals from individual cells combined with physical separation of cells of particular interest.
This facility provides services outside its institution
This facility provides consulting outside its institution
04/01/2020
Cell Imaging
Microarray
Seq-Well
Shanu Mehta
500 Main St
Building 76-273
Cambridge, MA 02139 - United States of America
RRID:SCR_017895
The Microengraving technology platform enables measuring multiple traits from individual immune cells, either in their native condition or upon stimulation. The modularity of the platform allows simultaneous assessment from small or large numbers of cells. Additionally, it is possible to obtain genetic information from the individual cells of interest.
To date, the platform has been employed in projects related to antibody discovery, tumor profiling from various cancer tissues, immune cell functions in various allergic, infectious or auto immune diseases.
This facility provides services outside its institution
This facility provides consulting outside its institution
09/20/2018
Animal Husbandry
Assisted Reproductive Technologies (Rodent IVF, ICSI)
Cell Culture
Embryo Cryopreservation & Recovery Services
Genotyping
Stem Cell Procurement
Tissue Culture
Transgenics
Noranne Enzer
500 Main St. 76-195
Cambridge, MA 02139 - United States of America
RRID:SCR_017899
This shared resource of the MIT Koch Institute provides fee-for-service support to investigators who utilize cultured stem cells such as organoids or novel mouse models to study human diseases.
We provide a customizable set of service options to match the specific needs of each project, including consultative advice and troubleshooting, complete tissue culture and microinjection servces within our dedicated facilities or hands-on training to enable investigators to perform these experiments either at their own laboratory or within our facilities.
This facility provides services outside its institution
This facility provides consulting outside its institution
12/14/2016
Computational - Bioinformatics
Charlie Whittaker
Koch Institute for Integrative Cancer Research at MIT
77 Massachusetts Avenue 76-189B
Cambridge, MA 02139 - United States of America
RRID:SCR_017894
The Barbara K. Ostrom (1978) Bioinformatics & Computing Facility is a shared institutional resource providing KI investigators with support, assistance and training in a wide range of bioinformatics topics. The core also maintains a high performance computing resource offering many bioinformatics applications, substantial processing power and secure storage and provides support for desktop computing and poster printing. Access is available to all members of the MIT community, to the extent permitted by available capacity. In recognition of funding support, priority access is given to members of the Core’s sponsoring entities (Koch Institute, MIT Biology, MIT Biological Engineering and MIT Center for Environmental Health Science) and NCI-funded research projects. In special circumstances, access may be available to non-MIT users (details available on request from the Facility Director, Charlie Whittaker)
This facility provides services outside its institution
This facility provides consulting outside its institution
12/05/2016
Copy Number Variation (CNV)
Genomics
Mass Spectrometry
Peptide Synthesis
Proteomics
RNA analysis
Sequencing - Capillary Sequencing
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Sequencing - Pyrosequencing
Richard Cook
76-181
attn: Richard Cook
Cambridge, MA 02139 - United States of America
RRID:SCR_017737
Fee-or-Service lab providing the following: "Next-gen" DNA/RNA sequencing; Sanger sequencing; small scale and multiple peptide synthesis; larger scale peptide synthesis; peptide cellulose array synthesis; MALDI-TOF mass spectrometry and HPLC analytical and preparative scale.
This facility does not provide services outside its institution
This facility does not consult outside its institution
03/01/2012
10x Genomics
Assays and Measurements
Consultations
DNA Analysis
Genomics
Genotyping
Library Services
Nanostring
Nanostring NCounter
Real-time qPCR
RNA analysis
RNA Integrity
Sequencing - Next Generation Sequencing (NGS)
Single-cell Sequencing
Sequencing
Susan Patalano-Salsman
100 Morrissey Blvd
4630 ISC
Boston, MA 02125 - United States of America
RRID:SCR_017858
The CPCT Genomics Core enables UMass Boston investigators and academic and industry collaborators to carry out basic and translational genomics research. The Core leverages cutting-edge technologies and next-generation sequencing capabilities for research and clinical applications. We help investigators and clinicians analyze samples, identify genetic variants contributing to disease risk, and reveal complex mechanisms involved in human disease.
The Core offers cost-effective massively parallel sequencing with the Illumina HiSeq 2500 (v4, 1TB enabled) and Illumina MiSeq platforms; 10X Genomics Chromium Single Cell Sequencing Platform; Nanostring nCounter Analysis System; next-generation sequencing library preparation from RNA and DNA, and nucleic acid quality assessments using Bioanalyzer, Tapestation, Nanodrop and Qubit assays. Additional instruments include a Biomek FXp automated workstation, and a QuantStudio 12K Flex Real-Time PCR System.
The Center for Personalized Cancer Therapy is a collaborative venture between the University of Massachusetts Boston and the Dana Farber/Harvard Cancer Center (DF/HCC) and funded by the Massachusetts Life Sciences Center.
This facility provides services outside its institution
This facility provides consulting outside its institution
04/01/2020
Biological Photography/Photomicrography
Confocal Microscopy
Fluorescence TUNEL Staining-Paraffin Sections
Fluorescence-multi-label Using Paraffin Sections
Fluorescence-single Label Using Paraffin Sections
Immunoperoxidase (IPOX) Using Frozen Sections
IPOX-Paraffin Sections
Labeling Of Frozen Sections Using A Single Fluorescence Label
Labeling Of Frozen Sections Using Multiple Fluorescence Labels
Near Super-resolution Confocal Microscopy
Pre-antibody Testing/optimization With New Antibodies.
Pre-experiment Consultation And Consultation Prior To Antibody Purchase
Widefield Microscopy
Microscopy (Electron, Fluorescence, Optical)
Hagen, Susan J
330 Brookline Ave # DA-814
Boston, MA 02215-5400 - United States
RRID:SCR_012312
The BIDMC Immunostaining and Microscopy Core offers consultation and service for tissue immunostaining with paraffin or frozen sections, and for training to use confocal and widefield microscopes. All service work and training is fee-for-service.
This facility provides services outside its institution
This facility provides consulting outside its institution
04/03/2025
Contrast Staining
Discussion Of Results (consultation) And Transfer Of Image Data Files (no Storage)
Evaluation Of The Sample Using The JEOL 1400 Electron Microscope
High Pressure Freezing
Image Analysis
Negative Staining For TEM
Pre-experiment Consultation For Methods And For Proper Fixation Techniques
Receipt Of Samples (sometimes Assisting With Sample Collection) Followed By Grossing And Processing Of Tissues, Suspended Cells, Bacteria, Cultured Cells, Organoids, Exosomes
Review Of Sections For Tissue Orientation And Histopathology
Thin Sectioning, Production And Use Of Formvar- And Carbon-coated Grids
Microscopy (Electron, Fluorescence, Optical)
Hagen, Susan J
330 Brookline Ave # GZB05
Boston, MA 02215-5400 - United States
RRID:SCR_009667
The BIDMC Electron Microscopy Core provides service for grossing, tissue processing, tissue embedding, thick and thin sectioning, staining grids, and taking images of samples in the electron microscope. Training is available to use the electron microscope independently. For tissue processing, we also have training or service for high pressure freezing, freeze substitution, and tissue embedding. The core also has the expertise to do Advanced 3-D Focused Ion Beam/Scanning Electron Microscopy and 3-D segmentation and analysis on cells or tissues.
This facility provides services outside its institution
This facility provides consulting outside its institution
04/03/2025
Blank Slides Cut For Immunostaining And Passed-on (if Needed) To The Immunostaining Service
Cassetting
Consultation For Pre-experiment Methods, Post-processing Orientation, And/or Special Staining
Grossing
Labeling Of Slides
Paraffin Or Frozen Block Sectioning
Processing Of Tissues, Cells, Or Organoids For Frozen Sectioning
Processing Of Tissues, Cells, Or Organoids For Paraffin Histology
Sample Receipt
Slides Are Boxed For Transport And Tissue Blocks Are Returned To The Investigator For Storage
Special Processing For Specialized Project Aims Or Histology Stains Are Available
Staining With Histology Stains Or Special Stains, Including Alcian Blue, Masson Trichrome, Oil-Red-O, PAS, Sirius Red, Toluidine Blue, And Alcian Blue/PAS
Histology
Hagen, Susan J
330 Brookline Ave, E/DA-812
Boston, MA 02215-5400 - United States
RRID:SCR_009669
The BIDMC Histology Core does routine paraffin and frozen sectioning on tissues for research purposes. We offer consultation services, and fee-for-service tissue grossing, processing, embedding, sectioning and staining. Special stains are also done routinely. Paraffin-embedded or frozen sections can be passed-on to a partner core, the BIDMC-Confocal and Immunostaining core, for DAB or fluorescence staining and analysis. No training or independent usage of the Histology core or its equipment is possible.
This facility provides services outside its institution
This facility provides consulting outside its institution
04/03/2025
Behavioral Assessment
Behavioral Phenotyping
Clinical Research
Consulting
Data Analysis And Interpretation
Data Visualization
Research Design
Behavioral Research
Sean Ryan
330 Brookline Avenue
Boston, MA 02215
The LAMP Platform is a neuropsychiatric research and clinical care management platform designed to help you run remote smartphone-based research studies that can include surveys (ecological momentary assessments), mobile cognitive tests, sensors (native to the smartphone and external), and digital interventions delivered via the smartphone. The LAMP Platform functions as 4 pieces, the App, the Dashboard, the Database, and Cortex.
This facility provides services outside its institution
This facility provides consulting outside its institution
03/28/2025
Bioluminsecence Imaging
Blood Cell Count
Blood Chemistry
Clinical Imaging - Small Animal (luminescence/fluorescence)
Animal Imaging
Sean Clohessy
3 Blackfan Circle
CLS417
Boston, MA 02215 - United States
RRID:SCR_026600
At the Longwood Small Animal Imaging Facility (SAIF), our mission is to provide state-of-the-art small animal imaging services to researchers in the Longwood Medical Area of Harvard Medical School, as well as external academic and corporate researchers. To that end, we have designed a dynamic facility to provide multi-modality imaging, advanced data analysis, image fusion resources, custom chemistry, and a satellite animal facility for longitudinal studies.
This facility provides services outside its institution
This facility provides consulting outside its institution
03/13/2025
Consultation
In Vivo Drug Evaluation
In-vivo Imaging
Xenograft / Xenotransplantation
Preclinical Modeling / Imaging
Sean Clohessy
3 Blackfan Circle,
CLS417
Boston, MA 02215
https://www.bidmc.org/research/core-facilities/preclinical-murine-pharmacogenetics-core
RRID:SCR_026599
The Core provides expertise in the design and implementation of preclinical trials to test new drugs, drug combinations and novel therapeutic modalities in mouse models of human diseases.
This facility provides services outside its institution
This facility provides consulting outside its institution
03/13/2025
Magnetic Resonance Imaging (MRI)
Magnetic Resonance
Aaron Grant
Dana Building Room 703
330 Brookline Avenue
Boston, MA 02215
https://www.bidmc.org/research/research-by-department/radiology/preclinical-mri-core
RRID:SCR_009674
The Preclinical MRI Core at Beth Israel Deaconess Medical Center provides state of the art imaging of anatomy and function for small animals including mice, rats, and amphibians. In addition, ex vivo samples from larger animals and patients can be imaged. The Core also provides consultation on protocol design and pilot data for new projects. Analysis services are available as well.
This facility provides services outside its institution
This facility does not consult outside its institution
03/11/2025
Magnetic Resonance Imaging (MRI)
Meaghan Strob
330 Brookline Avenue
Boston, MA 02215 - United States of America
RRID:SCR_017950
The Translational MRI Core of the BIDMC Department of Radiology provides state-of-the-art MRI capabilities for imaging human subjects and potentially large animals as part of research studies. The facility operates a GE Discovery MR750 3T whole-body scanner completely dedicated to research.
Located in the Ansin Building on BIDMC's East campus, the scanner is FDA cleared for clinical use. In addition to commercial tools for clinical imaging, it has proprietary software including pulse programming environments and reconstruction programs and customizable software and protocols for applications including functional and structural brain imaging, abdominal perfusion and diffusion, muscle functional imaging and spectroscopy are available to users.
We upgraded to the GE Discovery 3T MR750 in the winter of 2016. This new system includes state-of-the-art hardware and software. The scanner is equipped with an optically coupled radiofrequency system for improved signal-to-noise ratio and with high-duty-cycle 50 mT/m gradients at 200 T/m/s slew rate.
The 3T system has high-speed echo planar imaging capabilities. Support for fMRI acquisition and visual and auditory stimulus presentation, diffusion tensor imaging, spectroscopy, and high quality anatomic imaging is available. The system has specialized receiver coils for sensitive imaging of particular anatomy. Additional customized coils can be manufactured in our RF lab. The system also has full broadband capability for multinuclear MRI and MRS, including (F-19, C-13, P-31, and Na-23).
To achieve high homogeneity, the 3T MR750 system is equipped with high order resistive shimming coils as well as super-conducting shimming coils. Additionally, the scanner will use broadband transmission to permit multiple frequency excitation schemes, which are crucial for spectroscopy and multi-nuclear imaging experiments. The GE MR750 system uses Multi-Drive RF transmit, which will improve body imaging by reducing RF transmit non-uniformity and power deposition.
The system will include a 32-channel Head array coil, 16-channel Head Neck Spine array, 32-channel Body Array, 8-Channel Torso Array, Flex Coils in small, medium, and large, and will have the capability to use disposable probes for imaging the prostate, cervix, and colon. Our 3T system will continue to have capabilities for multinuclear MRI and MRS. Through our contract with GE, the system will be continuously updated with new features, hardware, and capability.
Our MRI Research Suite is equipped with a Medrad (Bayer) power injector for contrast administration and Medrad (Bayer) physiologic monitors. Subject monitoring within the magnet includes non-invasive measures of heart rate, blood pressure, pulse-oximetry, end tidal CO2 levels, and ECG recording.
This facility provides services outside its institution
This facility provides consulting outside its institution
03/11/2025
Biomarker Analysis
Digital Microscopic Assays
Multiplexed Biomarker Assays
Real Time Cellular Metabolism Assays
Research Design
Xiaowen Liu
330 Brookline Ave
DA 605
Boston, MA 02215 - United States
https://resuscitationscience.com/research/laboratory-research/
RRID:SCR_026518
The Biomarker and Metabolism Research Core provides access to XFe 96 Extracellular Flux Analyzer, seahorse technology, as well as additional services that include technical advice in experimental design, data analysis and basic training. The Core also provides affordable access to high‑performance, electrochemiluminescence immunoassays using MESO QuickPlex SQ 120. This instrument provides unparalleled sensitivity and dynamic range, using low sample volume, and fast, well-organized results. You can perform multiplex biomarker and cytokine assays, test for immunogenicity or toxicity, or we can help you develop your own unique assays. In addition, the Core provides access to ImageXpress Pico, the next generation of digital microscopy and access to SPECTRAMAX I3X, a multi-mode microplate reader.
This facility provides services outside its institution
This facility provides consulting outside its institution
02/28/2025
Biochemical Analysis
Computational - Bioinformatics
Data Analysis
Gel Chromatography
Lipidomics Profiling
Mass Spectrometry
Metabolomics
Metabolomics Platform
Protein Extraction/Purification
Protein Post-translational Modification (PTM) Identification
Proteomics
Sequencing - Capillary Sequencing
Sequencing - Protein Sequencing
Shared Instrumentation Oversight & Maintenance
Stable Isotope Tracing
Western Blot
John M. Asara, Ph.D.
3 Blackfan Circle, CLS-425
Beth Israel Deaconess Medical Center
Boston, MA 02115 - United States of America
RRID:SCR_017735
ABOUT US: The mass spectrometry, metabolomics and proteomics core at Beth Israel Deaconess Medical Center was established in 2004 led by Dr. John Asara and continues to grow rapidly. We provide excellent proteomics, metabolomics and lipidomics services with low prices and fast turnaround times. We have cutting edge equipment operated at optimal sensitivity and work and publish with world class researchers. We also maintain an active internal cancer proteomics and metabolomics/lipidomics research program with collaborative efforts. Our expertise is in identifying and quantifying protein modifications and dynamic protein-protein interactions in addition to polar metabolomics profiling, lipidomics profiling and 13C/15N metabolic flux analysis. We accept samples from anywhere in the world and look forward to helping you and progressing your research to the next level.
This facility provides services outside its institution
This facility does not consult outside its institution
02/11/2025
Exosomes Characterisation
FACS Cell Sorting
Flow Cytometric Analysis
Flow Cytometry Data Analysis
Flow Cytometry Training
Full Spectrum Flow Cytometry
High Dimensional Flow Cytometry Analysis
Imaging Flow Cytometry
NanoFACS
NanoFlow Cytometry Training Course
RNA Flow Cytometry
Single Particle Extracellular Vesicle Flow Cytometry
Spectral Flow Cytometry
Flow Cytometry and Microscopy
John C Tigges
3 Blackfan Road
Boston, MA 02215
https://www.bidmc.org/research/core-facilities/flow-cytometry-core
RRID:SCR_012305
Committed to meet all of the flow cytometry needs for the BIDMC and the external research community, the Flow Cytometry Core facility offers state of the art instrumentation for routine flow cytometry and cell sorting.
It is continuously expanding with the newest software and machinery for both sorting and analysis, with the capability of up to 48 fluorescent parameters.
This facility provides services outside its institution
This facility provides consulting outside its institution
02/03/2025
Bioinformatics
Winston Hide
330 Brookline Avenue (Dana 519)
Boston, MA 02215-549
RRID:SCR_025859
The BIDMC Bioinformatics Core, a Unit of the Precision RNA Medicine Core, provides support for analysis. It supports the management, integration and contextual analysis of biological high-throughput data, provide training on tools, databases and best practice.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/04/2024
Computational - Bioinformatics
Computational - Biostatistics
Consultation
Cytokine Assays
Data Analysis
Data Analysis And Interpretation
Data Visualization
Discovery Science
ELISA
Immunoassay
Pathway Interpretation
Proteomics
Proteomics Analysis
Sample Preparation
SomaScan Proteomics
Proteomics
Towia Libermann
99 Brookline Ave.
Research North Building
Boston, MA 02115 - United States of America
RRID:SCR_025689
The Center provides investigators access to comprehensive interdisciplinary, translational, and clinically-oriented facilities for high-sensitivity and high-throughput proteomics services. The Center has over 20 years of experience in precision medicine and proteomics biomarker discovery in tissue and biological fluids. We are the only service provider in the Boston are for the exciting and most comprehensive, highly multiplex 11,000-protein SomaScan v5.0 assay. We provide assistance in study design, experimental execution, data analysis, and systems biology, while also serving as a forum for education, scientific interactions, and cross-fertilization in proteomics.
This facility provides services outside its institution
This facility provides consulting outside its institution
08/13/2024
Genomics / Genome Analysis and Technologies
Anton Gulko
3 Blackfan Circle
Boston, MA 02445 - United States
https://www.baderc.org/cores/functional-genomics-and-bioinformatics-core/
RRID:SCR_024877
The Functional Genomics and Bioinformatics Core provides consultative, laboratory, and bioinformatic services for next generation sequencing (NGS)-based applications. The development of next generation sequencing (NGS) technologies have made it possible to address biological questions comprehensively and with less bias at a systems level. Taking advantage of these approaches can require specialized technical and analytical skills that may be out of reach or not worth the investment for individual laboratories. The goals of this Core are to provide better access to these methods in order to enhance and facilitate a deeper understanding of complex disease processes and how they can be diagnosed and treated.
The Core is located on the 7th floor of the Center for Life Sciences building in the Longwood Medical area (3 Blackfan Circle, CLS-728). While the majority of clients come from Boston area research communities, we also service customers around the country. Most clients are in the fields of metabolism, obesity, and diabetes, as NORC and DERC funding provide discounted fees, and represent the expertise of the co-drectors Evan Rosen and Linus Tsai, though we can and have performed services for a broad range of research areas.
Specifically, our core services include:
1) Pre- and post-experimental consultation to determine proper experimental approach, design, and interpretation
2) Standalone RNA preparation, RNA and DNA Bioanalyzer analyses, chromatin shearing/shear checks
3) Sample quality assessment of DNA and RNA using the BioAnalyzer and Qubit assays
4) Library preparation, sequencing, and analysis of transcriptomes (RNA-seq), cistromes (ChIP-seq), chromatin accessibility (ATAC-seq)
5) Standalone sequencing on NextSeq500
6) Multiplexed 10x Single Cell/Nucleus Library RNA-seq Droplet generation, Library Preparation
7) Basic data analysis: quality assessment and normalization, genomic alignment, differential expression/enrichment, functional enrichment analysis (overrepresentation and GSEA), sample clustering, and motif enrichment
8) Bespoke data analysis, including integration of complex ChIP-seq and RNA-seq data sets, single-cell sequencing analyses
This facility provides services outside its institution
This facility provides consulting outside its institution
01/24/2024
Ashton Black
Beth Israel Deaconess Medical Center
330 Brookline Ave ESB01A-H
Boston, MA 02215 - United States
RRID:SCR_024862
The Delivery Unit offers training and services on the NanoAssemblr Spark, NanoAssemblr Ignite+, and Malvern Zetasizer for the purpose of synthesis and characterisation of Lipid Nanoparticles (LNPs). The Zetasizer is able to read zeta potential and size of particles, including exosomes, liposomes, and LNPs.
This facility provides services outside its institution
This facility provides consulting outside its institution
01/16/2024
Glycolipid Analysis
Glycomics
Glycopeptide Mapping
Glycoproteomics
HPLC
Mass Spectrometry
Mass Spectrometry - Proteins And Peptides
Protocol Development
Lauren Pepi
330 Brookline Ave
SL-0417
Boston, MA 02155 - United States
https://www.bidmc.org/research/core-facilities/glycomics-core
RRID:SCR_024818
The Glycomics Core provides services, instrumentation and expertise in glycomics to BIDMC research groups, affiliated and non-affiliated institutions and corporate companies.
The services proposed by the Glycomics Core includes:
Glycan Microarrays
Glycan analysis by Mass Spectrometry
Distribution of specific reagents
Trainings
The work is done on a fee-for-service basis.
The National Center for Functional Glycomics (NCFG) is an outgrowth of the high successful Consortium for Functional Glycomics (CFG) funded by the NIGMS/NIH from 2001 to 2014. The CFG generated two types of glycan microarrays that are available as a fee-for-service and approved by the Steering Committee of the CFG. These are the CFG Glycan Microarray version 5.2, and the Microbial Glycan Microarray (MGM) (also previously termed the Pathogen Array). Dr. Cummings is the Chair of the CFG, a world-wide consortium of more than 600 Investigators whose research is funded in the area of glycobiology or related sciences.
The NCFG is devoted to understanding protein-glycan interactions and its major resources are developments of new glycan microarrays and other technologies to identify ligands recognized by glycan-binding proteins, antibodies, and microbes.
This facility provides services outside its institution
This facility provides consulting outside its institution
12/22/2023
Biochemical Analysis
Consultation
Data Processing
Micro RNA Profiling
Jan Heng
6 Blackfan Circle
Boston, MA 20115 - United States
RRID:SCR_024819
MicroRNA Screening
Our unit offers full service microRNA screening of bio specimens using Mirxes ID3EAL assays. This highly sensitive qPCR-based technology can simultaneously screen for up to 376 microRNAs.
We offer the following panels:
• ID3EAL™ PanoramiR Panel targets 376 miRNAs involved in signaling pathways or disease mechanism
• ID3EAL™ Cancer Panel targets 352 miRNAs commonly studied in cancer
This facility provides services outside its institution
This facility provides consulting outside its institution
12/22/2023
Harry Cramer
https://research.childrenshospital.org/resources/cores/cellular-imaging-core
RRID:SCR_026485
Cellular Imaging Core facility is light microscopy core in Boston Children's Hospital's Neurobiology Program. The Core maintains systems for Widefield, confocal, multiphoton, and lightsheet light microscopy as well as sample preparation and image processes tools and technologies to assist the microscopy community of Boston Children's Hospital in addition to the surrounding greater Boston area. Core services and equipment are available to all upon request, contact core staff for access.
This facility does not provide services outside its institution
This facility does not consult outside its institution
03/10/2025
BioBanking
Copy Number Variation (CNV)
DNA Analysis
Droplet Digital PCR
Genomics
Genotyping
Mass Spectrometry
Microarray
Molecular Library Services
Nucleic Acid Extraction
Real-time qPCR
RNA analysis
RNA Integrity
Sequencing - Capillary Sequencing
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Sequencing- Long Read Sequencing
Genomics / Genome Analysis and Technologies
3 Blackfan Circle
CLS 16009
Boston, MA 02115 - United States of America
https://www.childrenshospital.org/research/cores/molecular-genetics-core/contact-us
RRID:SCR_025866
The overall objective of the Molecular Genetics Core Facility is to provide high quality, low cost genomic technology services and expertise in a timely, affordable manner. Services offered include:
Nanopore PromethION sequencing
Electronic optical mapping on Nabsys
Optical Genome mapping on Bionano Saphyr
NGS (Illumina-based)
Sanger Sequencing
Single cell analysis/RNAseq
Transcriptomic spatial profiling
Gene expression analysis
Droplet Digital PCR & qPCR
Microsatellite/fragment analysis
SNP genotyping
Chromosomal microarray analysis
Sample prep & QC
Project consultation
Bioinformatics support
contact us at MGCF@childrens.harvard.edu
This facility provides services outside its institution
This facility provides consulting outside its institution
10/07/2024
Computational - Bioinformatics
Sequencing - Next Generation Sequencing (NGS)
Single-cell Sequencing
Ulandt Kim
185 Cambridge St
CPZN7402 (required for shipments)
Boston, MA 02114 - United States
RRID:SCR_026362
MGH NGS Core offers sequencing, upstream library construction (bulk RNA/DNA, single-cell), and post-sequencing analysis.
As of 2025 the core uses Illumina NextSeq 2000 sequencers (and a MiSeq). Single-cell (fresh, frozen, FFPE) libraries (3' & 5' RNA-Seq, CITE-Seq, ATAC-Seq, Multiome, FLEX) are made with 10X Chromium X.
This facility provides services outside its institution
This facility does not consult outside its institution
01/30/2025
Biostatistics
RRID:SCR_012323
Biostatistics core serves the needs of the HIV/AIDS researchers within the Ragon Institute and its affiliates at Harvard, MGH, MIT and University of Kwazulu Natal, South Africa. Provides expertise in planning, conduct and analysis of research with goal of enhancing scientific quality of HIV-related research at the institute. Primary objective is to ensure that studies are well designed, correctly analyzed, clearly presented, and correctly interpreted.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/10/2024
Cell Biology
RRID:SCR_015069
Services provided include tissue preparation, embedding and sectioning for electron microscopy, use of electron microscope and photography of thin sections, immunogold staining for electron microscopy, preparation and incubation of samples (cells and tissues) for immunofluorescence microscopy, confocal microscopy and digital imaging.
This facility does not provide services outside its institution
This facility does not consult outside its institution
07/29/2024
Computational - Bioinformatics
Data Analysis
DNA Analysis
Genomics
Genotyping
oligo synthesis
Sequencing - Capillary Sequencing
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
John Darga
38 Sidney Street, Suite 100
Cambridge, MA 02139 - United States of America
RRID:SCR_025307
The MGH CCIB DNA Core, founded in 1995, is a non-profit research core laboratory within the Center for Computational and Integrative Biology at Massachusetts General Hospital (Boston). It has a 25+ year track record of increasing research efficiency with trusted high-quality, cutting edge research services at competitive rates and of providing access to state-of-the-art instrumentation, methodologies and expertise.
This facility provides services outside its institution
This facility does not consult outside its institution
05/02/2024
Bioimage Informatics
Image Data Management
Image Processing And Analysis
Beth Cimini
415 Main Street
Cambridge, MA 02142 - United States
RRID:SCR_024653
The Broad Institute Imaging Platform (https://www.broadinstitute.org/imaging) helps users turn images into answers by offering assistance and training with open source image analysis tools, creating custom image analysis workflows, and even creating custom software for image analysis when needed. We are open to collaboration with academics, non-profits, and for-profit organizations.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/25/2023
DNA Analysis
DNA Isolation
Gene Expression Arrays
Library Services
RNA analysis
RNA Flow Cytometry
RNA Isolation
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Jack Lepine
Saab Emerging Technologies & Innovation Center
40 University Avenue
Lowell, MA 01854 - United States
https://www.uml.edu/research/crf/ourlabs/next-gen-sequencing-lab.aspx
RRID:SCR_024981
One of UMass Lowell’s Core Research Facilities, the Next Generation Sequencing & Genomics Lab provides Next-Generation DNA & RNA sequencing services and technical expertise including NGS library prep, DNA and RNA quality assessment, Fluorometric quantification of DNA/RNA/Protein, DNA & RNA isolation, PCR/qPCR, Qubit fluorometry, gene expression and drug development studies. Consultative services are also available.
This facility provides services outside its institution
This facility provides consulting outside its institution
01/30/2024
Atomic Layer Deposition
Consultation
Data Analysis
Fabrication
Nanofabrication
Photolithography
Nanotechnology
Justin Moreau
Saab Emerging Technologies & Innovation Center
40 University Ave
Lowell, MA 01854 - United States of America
RRID:SCR_024734
The Nanofabrication Lab features a state-of-the-art, 4,200 ft2 Class 100 clean room equipped with over 40 pieces of process and analytical instrumentation for complex research projects that require micro and nano scale fabrication.
This facility provides services outside its institution
This facility provides consulting outside its institution
01/30/2024
Data Analysis And Interpretation
Differential Scanning Calorimetry
Dynamic Mechanical Analysis
Thermal Analysis
Thermogravimetric Analysis
Violet Sullivan
SAAB Emerging Technologies & Innovation Center
40 University Avenue
Lowell, MA 01854 - United States
https://www.uml.edu/research/crf/ourlabs/therm-mech-prop-lab.aspx
RRID:SCR_024980
The Thermal & Mechanical Properties Lab houses a complete thermal analysis suite and is part of the Core Research Facilities. In this lab, researchers are able to investigate the behavior of a material under stress and temperature change. Service level work and technical expertise are also provided.
This facility provides services outside its institution
This facility provides consulting outside its institution
01/30/2024
Nuclear Magnetic Resonance (NMR)
Nuclear Magnetic Resonance
Wendy Gavin
Olney Hall
265 Riverside Street
Lowell, MA 01854 - United States
https://www.uml.edu/research/crf/ourlabs/nuc-mag-res-lab.aspx
RRID:SCR_024979
The Nuclear Magnetic Resonance Spectroscopy Lab features a state-of-the-art JEOL 400 MHz NMR equipped with auto sampling and automatic tuning & matching. The instrument can perform temperature and kinetic studies as well as x-nuclei and 2D experiments. A part of the Core Research Facilities, self-use and service work are available.
This facility provides services outside its institution
This facility provides consulting outside its institution
01/30/2024
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