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Harvard Medical School (HMS)

Established: 1782

http://hms.harvard.edu/

Location: Boston, United States

GeoNames Map

Alternate Identifiers

ROR ID: https://ror.org/03wevmz92

ISNI: 0000 0004 0378 0882

WikiData: Q49121

14 Core Facilities:

10 Service Outside the Institution

8 Consult Outside the Institution

Animal Behavior

Biophysics

Genomics / Genome Analysis and Technologies

Imaging (Cell, Molecular, PET, Translational)

Microscopy (Electron, Fluorescence, Optical)

Nuclear Magnetic Resonance

Transcriptomics

Transgenics

4D Image Processing Stations

3D Visualization

Cell Imaging

Central Laboratory Supply

Circular Dichroism (CD)

Clinical Imaging - Small Animal (luminescence/fluorescence)

Computational - Interactive Compute/storage

Confocal Microscope With FCS/FLIM Capabilities

Confocal Microscopy

Confocal/ Super Resolution Microscope

Consultation

Copy Number Variation (CNV)

Cryo-Ultra Microtomy

DNA Analysis

Data Analysis And Interpretation

Data Processing

Data Visualization

Deconvolution

Differential Scanning Fluorimetry (DSF)

ES Cell Electroporation

ES Cell Injection

ES Cell Technology (Mouse)

Embryo Cryopreservation & Recovery Services

Fluorescence Lifetime

Fluorescence Microscope With Optical Sectioning Capability

Fragment-based Screening

Freeze Substitution

Fresh/Frozen Sperm IVF

Genomics

Genotyping

High Performance Computing3D &

High Pressure Freezing

Image Aquisition

Immuno Electron Microscopy

Immunofluorescence

In-vivo Imaging

Injection Of DNA Constructs

Isothermal Titration Calorimetry (ITC)

Library Services

Light Scattering

Live Cell Imaging

Mass Photometry

Metabolomics

MicroScale Thermophoresis (MST)

Microscopy

Microtomy/Electron

Molecular Library Services

Multiphoton Microscopy

Multiphoton/ Harmonic Generation Microscope

NMR Medicinal Chemistry Support

NMR Quality Control For Biologic Drugs

NMR Quality Control For Biosimilars

Natural Product Analysis

Negative Staining For TEM

Nuclear Magnetic Resonance (NMR)

Nucleic Acid Extraction

Optical Imaging

Optical ImagingFragment-based Drug Discovery

PCR Arrays

Protein NMR

RNA Integrity

RNA analysis

Real-time qPCR

Sample Preparation

Scanning Electron Microscopy

Sequencing - Capillary Sequencing

Sequencing - DNA Sequencing

Sequencing - Next Generation Sequencing (NGS)

Shared Instrumentation Oversight & MaintenanceCritical Point Drying

Spatial Transcriptomics

Sperm Cryopreservation

Sputter Coating

Structure DeterminationCRISPR Injection Services

Super-resolution Microscopy

Surface Plasmon Resonance (SPR)Cell Imaging

TIRF Microscopy

Tail BiopsyComputational - High Performance Computing

Training

Transmission Electron MicroscopyBiolayer Interferometry (BLI)

Whole Slide Imaging

Widefield Microscopy

oligo synthesis

Harvard Medical School ICCB-Longwood Screening Core FacilityRRID:SCR_009798

Resources:
Contact Info:

Jennifer Smith

https://iccb.med.harvard.edu/

RRID:

RRID:SCR_009798

Description:

Facility is small molecule and functional genomics high-throughput screening laboratory. It is built around modular work stations and most assays are performed in 384-well plates. There are over 500,000 small molecules available for screening at ICCB-Longwood and compound collection is continuously growing. Whole human and mouse genome siRNA libraries, arrayed sgRNA libraries, lncRNA siRNA libraries, as well as miRNA mimic and inhibitor libraries, are also available for screening. These libraries can be screened at the genome level or in focused subsets.

This facility does not provide services outside its institution

This facility does not consult outside its institution

Last updated:

12/10/2024

Biopolymers FacilityRRID:SCR_007175

Services:

Central Laboratory Supply

Copy Number Variation (CNV)

DNA Analysis

Genomics

Genotyping

Library Services

Molecular Library Services

Nucleic Acid Extraction

oligo synthesis

PCR Arrays

Real-time qPCR

RNA analysis

RNA Integrity

Sequencing - Capillary Sequencing

Sequencing - DNA Sequencing

Sequencing - Next Generation Sequencing (NGS)

Shared Instrumentation Oversight & Maintenance

Resources:

Genomics / Genome Analysis and Technologies

Contact Info:

Robert Steen

NRB 088

77 Avenue Louis Pasteur

Boston, MA 02115 - United States of America

https://genome.med.harvard.edu/

Google Maps Location

RRID:

RRID:SCR_007175

Description:

-About the BPF-

The Biopolymers Facility is a non-profit genomics core facility at Harvard Medical School. The investigators at Harvard Medical School make up the primary client base of the BPF. We also serve labs at schools, universities and biotechnology companies from all across the country.

Services offered include:
-Sanger DNA Sequencing
-Next-Generation DNA Sequencing (Four Illumina MiSeqs, four Illumina NextSeq 500s and one Illumina NovaSeq 6000)
-Next-Generation Automated Library Sample Prep (Perkin Elmer Sciclone -- Genomic, ChIP, RNA-seq and other methods)
-Single Cell DNA and RNA-Seq (10X Genomics Chromium)
-Bioanalyzer Analysis DNA and RNA (Two Agilent 2100 BioAnalyzers and two Agilent 2200 TapeStations)
-Qiagen Qiacube Automated DNA / RNA Prep (single to multiple samples)
-Oligonucleotide Ordering (IDT Portal)
-Reagents and Supplies Ordering (multiple vendors / products)

The facility has a comprehensive web based Laboratory Information Management System (LIMS) which provides our users with access to order services and supplies as well as retrieve data and review and pay invoices all online.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

11/29/2024

HMS Conventional Electron Microscopy FacilityRRID:SCR_009793

Services:

Critical Point Drying

Cryo-Ultra Microtomy

Freeze Substitution

High Pressure Freezing

Immuno Electron Microscopy

Microtomy/Electron

Negative Staining For TEM

Sample Preparation

Scanning Electron Microscopy

Sputter Coating

Transmission Electron Microscopy

Resources:

Microscopy (Electron, Fluorescence, Optical)

Contact Info:

220 Longwood Avenue

Boston, MA 02115 - United States

https://electron-microscopy.hms.harvard.edu/

Google Maps Location

RRID:

RRID:SCR_009793

Description:

The HMS Electron Microscopy Facility makes high quality electron microscopy services, instrumentation and training easily accessible to all researchers. Our services include consultation and experimental design for a wide variety of biological samples for both SEM and TEM.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

10/10/2024

Harvard Medical School Neurobiology Imaging Core FacilityRRID:SCR_009808

Resources:

Imaging (Cell, Molecular, PET, Translational)

Contact Info:

Celia Muto

https://nif.hms.harvard.edu/

RRID:

RRID:SCR_009808

Description:

Open access light microscopy and tissue core located within Neurobiology Department.
Provides services in optical imaging, tissue clearing, in situ hybridization as well as introduces new equipment and cutting technology to the basic science community. Provides expertise, equipment, services and learning opportunities to researchers in the greater Boston area.

This facility does not provide services outside its institution

This facility does not consult outside its institution

Last updated:

10/04/2024

Harvard Medical School Single Cell Core FacilityRRID:SCR_025837

Resources:

Transcriptomics

Contact Info:

Mandovi Chatterjee

https://singlecellcore.hms.harvard.edu

RRID:

RRID:SCR_025837

Description:

Core specializes in single cell and spatial transcriptomics, and multiomics. Provides custom services, education, training and expertise in multiple high-throughput single cell technologies.

This facility does not provide services outside its institution

This facility does not consult outside its institution

Last updated:

10/04/2024

Harvard Medical School Nascent Transcriptomics Core FacilityRRID:SCR_025844

Resources:

Transcriptomics

Contact Info:

Seth Goldman

https://ntc.hms.harvard.edu/

RRID:

RRID:SCR_025844

Description:

Core specializes in analysis of nascent transcriptome using PRO-seq and TT-seq NGS methods. Provides services allowing users to submit prepared cells and receive analyzed data. Offers free consultations to help with experimental design, answer questions, and discuss data analysis.

This facility does not provide services outside its institution

This facility does not consult outside its institution

Last updated:

10/04/2024

HMS Mouse Behavior CoreRRID:SCR_025842

Resources:

Animal Behavior

Contact Info:

Barbara Caldarone

4 Blackfan Circle

Boston, MA 02115

https://behavior.hms.harvard.edu/

RRID:

RRID:SCR_025842

Description:

The Mouse Behavior Core (MBC) offers a wide range of mouse behavioral equipment and assays to test a motor, cognitive, and affective behaviors. Trained users have access to eight behavioral testing rooms and a procedure room. The MBC staff offers consultation, training, and guidance in execution and interpretation of assays.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

10/02/2024

Harvard Cryo-Electron Microscopy Center for Structural BiologyRRID:SCR_025841

Resources:

Microscopy (Electron, Fluorescence, Optical)

Contact Info:

250 Longwood Ave, Boston MA 02115

Seeley G. Mudd B04

Boston, MA 02115

https://cryoem.hms.harvard.edu

RRID:

RRID:SCR_025841

Description:

The Harvard Cryo-Electron Microscopy Center for Structural Biology is a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital to provide state-of-the-art cryo-EM instrumentation and expertise for the Harvard structural biology community. This user facility offers consultation and training by staff in specimen preparation, microscope operation, image acquisition, and data analysis.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

10/02/2024

Center for Macromolecular InteractionsRRID:SCR_018270

Services:

Biolayer Interferometry (BLI)

Circular Dichroism (CD)

Differential Scanning Fluorimetry (DSF)

Isothermal Titration Calorimetry (ITC)

Light Scattering

Mass Photometry

MicroScale Thermophoresis (MST)

Surface Plasmon Resonance (SPR)

Resources:

Biophysics

Contact Info:

Kelly Arnett

240 Longwood Ave.

Building C, room 303

Boston, MA 02115 - United States of America

cmi.hms.harvard.edu

Google Maps Location

RRID:

RRID:SCR_018270

Description:

The Center for Macromolecular Interactions (CMI) in the department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School provides scientific consultation, training and access to shared biophysical equipment for the characterization and analysis of macromolecules and their complexes.

The facility offers training and access to instruments to measure molecular interactions by Isothermal Titration Calorimetry (ITC), Surface Plasmon Resonance (SPR), Biolayer Interferometry (BLI), MicroScale Thermophoresis (MST).

The facility also offers select data collection services, training and access on instruments to assess protein quality and biophysical properties by Differential Scanning Fluorimetry (DSF), Circular Dichroism (CD), Analytical Size Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS), Dynamic Light Scattering (DLS) and Mass Photometry (MP).

Using libraries developed in the lab of Andrew Kruse, the CMI is also offering yeast surface display nanobody selections services.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

05/03/2024

PCMM Microscopy Core at Boston Children's HospitalRRID:SCR_018822

Services:

Cell Imaging

Confocal Microscopy

Microscopy

Multiphoton Microscopy

Optical Imaging

Resources:

Microscopy (Electron, Fluorescence, Optical)

Contact Info:

Harry Leung

200 Longwood Ave

Boston, MA 02115 - United States

https://childrenshospital.corefacilities.org/service_center/show_external/3145

Google Maps Location

RRID:

RRID:SCR_018822

Description:

confocal/multiphoton microscopy/electron microscopy/image analysis

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

05/01/2024

HMS-Biomolecular NMR CoreRRID:SCR_022967

Services:

Fragment-based Drug Discovery

Fragment-based Screening

Metabolomics

Natural Product Analysis

NMR Medicinal Chemistry Support

NMR Quality Control For Biologic Drugs

NMR Quality Control For Biosimilars

Nuclear Magnetic Resonance (NMR)

Protein NMR

Structure Determination

Resources:

Nuclear Magnetic Resonance

Contact Info:

Gregory Heffron

Bio-NMR Core, Harvard Medical School

200 Longwood Avenue

Boston, MA 02115 - United States of America

https://eqnmr.med.harvard.edu

Google Maps Location

RRID:

RRID:SCR_022967

Description:

State-of-the-art resource for NMR that offers services in fragment-based screening and drug discovery, characterization and QC of biologics and biosimilar drugs, metabolomics, protein NMR, small molecule NMR, and NMR of natural products. The facility offers 400-700MHz systems, many with cryogenic probes. The staff is highly experienced and dedicated.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

11/14/2022

DF/HCC Mouse Engineering CoreRRID:SCR_022950

Services:

CRISPR Injection Services

Embryo Cryopreservation & Recovery Services

ES Cell Electroporation

ES Cell Injection

ES Cell Technology (Mouse)

Fresh/Frozen Sperm IVF

Injection Of DNA Constructs

Sperm Cryopreservation

Tail Biopsy

Resources:

Transgenics

Contact Info:

Michael Peluso

77 Avenue Louis Pasteur

NRB 837

Boston, MA 02115 - United States

https://www.dfhcc.harvard.edu/research/core-facilities/mouse-engineering/

Google Maps Location

RRID:

RRID:SCR_022950

Description:

The Mouse Engineering Core was established in 1992 operating at the BWH, and is now located at Harvard Medical School. The Mouse Engineering Core provides services for the generation of transgenic and knockout mice using state-of-the-art facilities and equipment.

The Core has all of the equipment necessary for generation of transgenic mice including a Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation and transfer, a sutter needle puller and a de Fonbrune microforge. The facility maintains mice necessary for egg donors, egg recipients, and vasectomized males.

ES cell culture services have been offered for 15 years. The core offers electroporation of targeting vectors into ES cells and provides investigators with DNA to identify ES cells carrying the desired recombination events; and ES cell expansion for microinjection into blastocysts.

The core\'s newest services include CRISPR injections, sperm and embryo cryopreservation, and reanimation with fresh or frozen sperm via IVF or the thawing and implanting embryos.

This facility provides services outside its institution

This facility does not consult outside its institution

Last updated:

11/07/2022

HMS Research Computing CoreRRID:SCR_022289

Services:

Computational - High Performance Computing

Computational - Interactive Compute/storage

High Performance Computing

Resources:
Contact Info:

Neil Coplan

401 Park Drive

Boston, MA 02115 - United States

https://it.hms.harvard.edu/rc/core

Google Maps Location

RRID:

RRID:SCR_022289

Description:

The Research Computing Core is a set of research computing services provided by the Department of Information Technology at Harvard Medical School. The facilities include a high performance computing environment, O2, computational storage, and other services that support biomedical research such as research software licensing. Our services are only available to Harvard Medical School, Harvard University, and HMS Affiliates https://hms.harvard.edu/about-hms/hms-affiliates.

This facility provides services outside its institution

This facility does not consult outside its institution

Last updated:

05/17/2022

HMS-MicRoNRRID:SCR_022209

Services:

3D &

4D Image Processing Stations

3D Visualization

Cell Imaging

Clinical Imaging - Small Animal (luminescence/fluorescence)

Confocal Microscope With FCS/FLIM Capabilities

Confocal Microscopy

Confocal/ Super Resolution Microscope

Consultation

Data Analysis And Interpretation

Data Processing

Data Visualization

Deconvolution

Fluorescence Lifetime

Fluorescence Microscope With Optical Sectioning Capability

Image Aquisition

Immunofluorescence

In-vivo Imaging

Live Cell Imaging

Microscopy

Multiphoton Microscopy

Multiphoton/ Harmonic Generation Microscope

Optical Imaging

Spatial Transcriptomics

Super-resolution Microscopy

TIRF Microscopy

Training

Whole Slide Imaging

Widefield Microscopy

Resources:
Contact Info:

Paula Montero Llopis

77 Avenue Louis Pasteur NRB1032 A

Boston, MA 02115 - United States

https://micron.hms.harvard.edu/

Google Maps Location

RRID:

RRID:SCR_022209

Description:

The Microscopy Resources On the North Quad (MicRoN) facility is a light microscopy core established by the Departments of Genetics, Immunology and Microbiology, and it is open to all HMS researchers, including Affiliated hospitals. MicRoN is a non-traditional decentralized or "floating" microscopy core. We support a wide range of imaging modalities ranging from widefield, TIRF, spinning disk and single point scanning confocal, multiphoton, FLIM and supper-resolution. The 14 microscopes that currently make up the core are embedded within the Departments of Microbiology, Immunology, and Genetics, housed in five microscope rooms on five floors of NRB and HIM. We find that this model generates a greater interaction among trainees from the three departments and encourages a more collaborative environment. We are proud of working with the Departments of Genetics, Microbiology and Immunology and would love hearing from you!

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

04/26/2022