Harvard Medical School (HMS)
Established: 1782
Location: Boston, United States
Harvard Medical School (HMS)
Established: 1782
Location: Boston, United States
14 Core Facilities:
10 Service Outside the Institution
8 Consult Outside the Institution
Animal Behavior
Biophysics
Genomics / Genome Analysis and Technologies
Imaging (Cell, Molecular, PET, Translational)
Microscopy (Electron, Fluorescence, Optical)
Nuclear Magnetic Resonance
Transcriptomics
Transgenics
4D Image Processing Stations
3D Visualization
Cell Imaging
Central Laboratory Supply
Circular Dichroism (CD)
Clinical Imaging - Small Animal (luminescence/fluorescence)
Computational - Interactive Compute/storage
Confocal Microscope With FCS/FLIM Capabilities
Confocal Microscopy
Confocal/ Super Resolution Microscope
Consultation
Copy Number Variation (CNV)
Cryo-Ultra Microtomy
DNA Analysis
Data Analysis And Interpretation
Data Processing
Data Visualization
Deconvolution
Differential Scanning Fluorimetry (DSF)
ES Cell Electroporation
ES Cell Injection
ES Cell Technology (Mouse)
Embryo Cryopreservation & Recovery Services
Fluorescence Lifetime
Fluorescence Microscope With Optical Sectioning Capability
Fragment-based Screening
Freeze Substitution
Fresh/Frozen Sperm IVF
Genomics
Genotyping
High Performance Computing3D &
High Pressure Freezing
Image Aquisition
Immuno Electron Microscopy
Immunofluorescence
In-vivo Imaging
Injection Of DNA Constructs
Isothermal Titration Calorimetry (ITC)
Library Services
Light Scattering
Live Cell Imaging
Mass Photometry
Metabolomics
MicroScale Thermophoresis (MST)
Microscopy
Microtomy/Electron
Molecular Library Services
Multiphoton Microscopy
Multiphoton/ Harmonic Generation Microscope
NMR Medicinal Chemistry Support
NMR Quality Control For Biologic Drugs
NMR Quality Control For Biosimilars
Natural Product Analysis
Negative Staining For TEM
Nuclear Magnetic Resonance (NMR)
Nucleic Acid Extraction
Optical Imaging
Optical ImagingFragment-based Drug Discovery
PCR Arrays
Protein NMR
RNA Integrity
RNA analysis
Real-time qPCR
Sample Preparation
Scanning Electron Microscopy
Sequencing - Capillary Sequencing
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Shared Instrumentation Oversight & MaintenanceCritical Point Drying
Spatial Transcriptomics
Sperm Cryopreservation
Sputter Coating
Structure DeterminationCRISPR Injection Services
Super-resolution Microscopy
Surface Plasmon Resonance (SPR)Cell Imaging
TIRF Microscopy
Tail BiopsyComputational - High Performance Computing
Training
Transmission Electron MicroscopyBiolayer Interferometry (BLI)
Whole Slide Imaging
Widefield Microscopy
oligo synthesis
RRID:SCR_009798
Facility is small molecule and functional genomics high-throughput screening laboratory. It is built around modular work stations and most assays are performed in 384-well plates. There are over 500,000 small molecules available for screening at ICCB-Longwood and compound collection is continuously growing. Whole human and mouse genome siRNA libraries, arrayed sgRNA libraries, lncRNA siRNA libraries, as well as miRNA mimic and inhibitor libraries, are also available for screening. These libraries can be screened at the genome level or in focused subsets.
This facility does not provide services outside its institution
This facility does not consult outside its institution
12/10/2024
Central Laboratory Supply
Copy Number Variation (CNV)
DNA Analysis
Genomics
Genotyping
Library Services
Molecular Library Services
Nucleic Acid Extraction
oligo synthesis
PCR Arrays
Real-time qPCR
RNA analysis
RNA Integrity
Sequencing - Capillary Sequencing
Sequencing - DNA Sequencing
Sequencing - Next Generation Sequencing (NGS)
Shared Instrumentation Oversight & Maintenance
Genomics / Genome Analysis and Technologies
Robert Steen
NRB 088
77 Avenue Louis Pasteur
Boston, MA 02115 - United States of America
RRID:SCR_007175
-About the BPF-
The Biopolymers Facility is a non-profit genomics core facility at Harvard Medical School. The investigators at Harvard Medical School make up the primary client base of the BPF. We also serve labs at schools, universities and biotechnology companies from all across the country.
Services offered include:
-Sanger DNA Sequencing
-Next-Generation DNA Sequencing (Four Illumina MiSeqs, four Illumina NextSeq 500s and one Illumina NovaSeq 6000)
-Next-Generation Automated Library Sample Prep (Perkin Elmer Sciclone -- Genomic, ChIP, RNA-seq and other methods)
-Single Cell DNA and RNA-Seq (10X Genomics Chromium)
-Bioanalyzer Analysis DNA and RNA (Two Agilent 2100 BioAnalyzers and two Agilent 2200 TapeStations)
-Qiagen Qiacube Automated DNA / RNA Prep (single to multiple samples)
-Oligonucleotide Ordering (IDT Portal)
-Reagents and Supplies Ordering (multiple vendors / products)
The facility has a comprehensive web based Laboratory Information Management System (LIMS) which provides our users with access to order services and supplies as well as retrieve data and review and pay invoices all online.
This facility provides services outside its institution
This facility provides consulting outside its institution
11/29/2024
Critical Point Drying
Cryo-Ultra Microtomy
Freeze Substitution
High Pressure Freezing
Immuno Electron Microscopy
Microtomy/Electron
Negative Staining For TEM
Sample Preparation
Scanning Electron Microscopy
Sputter Coating
Transmission Electron Microscopy
Microscopy (Electron, Fluorescence, Optical)
220 Longwood Avenue
Boston, MA 02115 - United States
RRID:SCR_009793
The HMS Electron Microscopy Facility makes high quality electron microscopy services, instrumentation and training easily accessible to all researchers. Our services include consultation and experimental design for a wide variety of biological samples for both SEM and TEM.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/10/2024
Imaging (Cell, Molecular, PET, Translational)
RRID:SCR_009808
Open access light microscopy and tissue core located within Neurobiology Department.
Provides services in optical imaging, tissue clearing, in situ hybridization as well as introduces new equipment and cutting technology to the basic science community. Provides expertise, equipment, services and learning opportunities to researchers in the greater Boston area.
This facility does not provide services outside its institution
This facility does not consult outside its institution
10/04/2024
Transcriptomics
RRID:SCR_025837
Core specializes in single cell and spatial transcriptomics, and multiomics. Provides custom services, education, training and expertise in multiple high-throughput single cell technologies.
This facility does not provide services outside its institution
This facility does not consult outside its institution
10/04/2024
Transcriptomics
RRID:SCR_025844
Core specializes in analysis of nascent transcriptome using PRO-seq and TT-seq NGS methods. Provides services allowing users to submit prepared cells and receive analyzed data. Offers free consultations to help with experimental design, answer questions, and discuss data analysis.
This facility does not provide services outside its institution
This facility does not consult outside its institution
10/04/2024
Animal Behavior
RRID:SCR_025842
The Mouse Behavior Core (MBC) offers a wide range of mouse behavioral equipment and assays to test a motor, cognitive, and affective behaviors. Trained users have access to eight behavioral testing rooms and a procedure room. The MBC staff offers consultation, training, and guidance in execution and interpretation of assays.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/02/2024
Microscopy (Electron, Fluorescence, Optical)
250 Longwood Ave, Boston MA 02115
Seeley G. Mudd B04
Boston, MA 02115
RRID:SCR_025841
The Harvard Cryo-Electron Microscopy Center for Structural Biology is a joint effort by Harvard Medical School, Dana-Farber Cancer Institute, Boston Children’s Hospital, and Massachusetts General Hospital to provide state-of-the-art cryo-EM instrumentation and expertise for the Harvard structural biology community. This user facility offers consultation and training by staff in specimen preparation, microscope operation, image acquisition, and data analysis.
This facility provides services outside its institution
This facility provides consulting outside its institution
10/02/2024
Biolayer Interferometry (BLI)
Circular Dichroism (CD)
Differential Scanning Fluorimetry (DSF)
Isothermal Titration Calorimetry (ITC)
Light Scattering
Mass Photometry
MicroScale Thermophoresis (MST)
Surface Plasmon Resonance (SPR)
Biophysics
Kelly Arnett
240 Longwood Ave.
Building C, room 303
Boston, MA 02115 - United States of America
RRID:SCR_018270
The Center for Macromolecular Interactions (CMI) in the department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School provides scientific consultation, training and access to shared biophysical equipment for the characterization and analysis of macromolecules and their complexes.
The facility offers training and access to instruments to measure molecular interactions by Isothermal Titration Calorimetry (ITC), Surface Plasmon Resonance (SPR), Biolayer Interferometry (BLI), MicroScale Thermophoresis (MST).
The facility also offers select data collection services, training and access on instruments to assess protein quality and biophysical properties by Differential Scanning Fluorimetry (DSF), Circular Dichroism (CD), Analytical Size Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS), Dynamic Light Scattering (DLS) and Mass Photometry (MP).
Using libraries developed in the lab of Andrew Kruse, the CMI is also offering yeast surface display nanobody selections services.
This facility provides services outside its institution
This facility provides consulting outside its institution
05/03/2024
Cell Imaging
Confocal Microscopy
Microscopy
Multiphoton Microscopy
Optical Imaging
Microscopy (Electron, Fluorescence, Optical)
Harry Leung
200 Longwood Ave
Boston, MA 02115 - United States
https://childrenshospital.corefacilities.org/service_center/show_external/3145
RRID:SCR_018822
confocal/multiphoton microscopy/electron microscopy/image analysis
This facility provides services outside its institution
This facility provides consulting outside its institution
05/01/2024
Fragment-based Drug Discovery
Fragment-based Screening
Metabolomics
Natural Product Analysis
NMR Medicinal Chemistry Support
NMR Quality Control For Biologic Drugs
NMR Quality Control For Biosimilars
Nuclear Magnetic Resonance (NMR)
Protein NMR
Structure Determination
Nuclear Magnetic Resonance
Gregory Heffron
Bio-NMR Core, Harvard Medical School
200 Longwood Avenue
Boston, MA 02115 - United States of America
RRID:SCR_022967
State-of-the-art resource for NMR that offers services in fragment-based screening and drug discovery, characterization and QC of biologics and biosimilar drugs, metabolomics, protein NMR, small molecule NMR, and NMR of natural products. The facility offers 400-700MHz systems, many with cryogenic probes. The staff is highly experienced and dedicated.
This facility provides services outside its institution
This facility provides consulting outside its institution
11/14/2022
CRISPR Injection Services
Embryo Cryopreservation & Recovery Services
ES Cell Electroporation
ES Cell Injection
ES Cell Technology (Mouse)
Fresh/Frozen Sperm IVF
Injection Of DNA Constructs
Sperm Cryopreservation
Tail Biopsy
Transgenics
Michael Peluso
77 Avenue Louis Pasteur
NRB 837
Boston, MA 02115 - United States
https://www.dfhcc.harvard.edu/research/core-facilities/mouse-engineering/
RRID:SCR_022950
The Mouse Engineering Core was established in 1992 operating at the BWH, and is now located at Harvard Medical School. The Mouse Engineering Core provides services for the generation of transgenic and knockout mice using state-of-the-art facilities and equipment.
The Core has all of the equipment necessary for generation of transgenic mice including a Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation and transfer, a sutter needle puller and a de Fonbrune microforge. The facility maintains mice necessary for egg donors, egg recipients, and vasectomized males.
ES cell culture services have been offered for 15 years. The core offers electroporation of targeting vectors into ES cells and provides investigators with DNA to identify ES cells carrying the desired recombination events; and ES cell expansion for microinjection into blastocysts.
The core\'s newest services include CRISPR injections, sperm and embryo cryopreservation, and reanimation with fresh or frozen sperm via IVF or the thawing and implanting embryos.
This facility provides services outside its institution
This facility does not consult outside its institution
11/07/2022
Computational - High Performance Computing
Computational - Interactive Compute/storage
High Performance Computing
Neil Coplan
401 Park Drive
Boston, MA 02115 - United States
RRID:SCR_022289
The Research Computing Core is a set of research computing services provided by the Department of Information Technology at Harvard Medical School. The facilities include a high performance computing environment, O2, computational storage, and other services that support biomedical research such as research software licensing. Our services are only available to Harvard Medical School, Harvard University, and HMS Affiliates https://hms.harvard.edu/about-hms/hms-affiliates.
This facility provides services outside its institution
This facility does not consult outside its institution
05/17/2022
3D &
4D Image Processing Stations
3D Visualization
Cell Imaging
Clinical Imaging - Small Animal (luminescence/fluorescence)
Confocal Microscope With FCS/FLIM Capabilities
Confocal Microscopy
Confocal/ Super Resolution Microscope
Consultation
Data Analysis And Interpretation
Data Processing
Data Visualization
Deconvolution
Fluorescence Lifetime
Fluorescence Microscope With Optical Sectioning Capability
Image Aquisition
Immunofluorescence
In-vivo Imaging
Live Cell Imaging
Microscopy
Multiphoton Microscopy
Multiphoton/ Harmonic Generation Microscope
Optical Imaging
Spatial Transcriptomics
Super-resolution Microscopy
TIRF Microscopy
Training
Whole Slide Imaging
Widefield Microscopy
Paula Montero Llopis
77 Avenue Louis Pasteur NRB1032 A
Boston, MA 02115 - United States
RRID:SCR_022209
The Microscopy Resources On the North Quad (MicRoN) facility is a light microscopy core established by the Departments of Genetics, Immunology and Microbiology, and it is open to all HMS researchers, including Affiliated hospitals. MicRoN is a non-traditional decentralized or "floating" microscopy core. We support a wide range of imaging modalities ranging from widefield, TIRF, spinning disk and single point scanning confocal, multiphoton, FLIM and supper-resolution. The 14 microscopes that currently make up the core are embedded within the Departments of Microbiology, Immunology, and Genetics, housed in five microscope rooms on five floors of NRB and HIM. We find that this model generates a greater interaction among trainees from the three departments and encourages a more collaborative environment. We are proud of working with the Departments of Genetics, Microbiology and Immunology and would love hearing from you!
This facility provides services outside its institution
This facility provides consulting outside its institution
04/26/2022