1230 York Avenue
New York, NY 10065http://www.rockefeller.edu/htsrc/index
Last Updated: 10/01/2018
The High-Throughput Screening Resource Center (HTSRC) supports scientists in the screening and identification of compounds and genetic modulators of in vitro assays which utilize optical and other bio-analytical technologies. The center has a collection of 169,000 compounds, automated liquid transfer devices, compound databases, and supports a broad diversity of assay development techniques, typically found in early drug discovery programs. The High- Throughput Screening Resource Center also oversees the management of, training for and scheduling for optical spectroscopic and calorimetric equipment for use in studies of the structure, function and interactions of biological and organic molecules.
The center is staffed full-time under an open-access model, whereby, once trained, investigators can use the facility 24/7. The staff includes a director with over 20 years of screening and drug discovery experience in the pharmaceutical industry, who is readily available for scientific and technical consultations, and three research associates, who support the automation, data processing, liquid handling and instrument QC and maintenance. The Center has the capacity to support approximately 15 full high throughput screening (HTS) projects per year, in addition to various pre-HTS and post-HTS activities.
The center is directed by J. Fraser Glickman who has a Ph.D. in biochemistry from UC Santa Barbara and over two decades of experience in drug discovery and HTS including a decade working in the pharmaceutical industry. Dr. Glickman has been directing the HTSRC since 2008.
The center occupies 1500 sq. ft. of lab space located on the Rockefeller campus on the Upper East Side of Manhattan in proximity to Weill-Cornell Medical College, Memorial-Sloan Kettering Cancer Center and the NYU Langone Medical Center. The lab space is equipped with assay development workbenches and data analysis workstations, analytical instruments, electronic automated pipetters and houses a full cell culture facility. Cell dispensing can be done under full laminar flow biosafety cabinets, and the center is certified for work at BSL2.
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