The CoreMarketplace: University of Pennsylvania Perelman School of Medicine Stem Cell and Xenograft Core Facility

3400 Civic Center Blvd

Philadelphia, PA 19104

United States

https://www.med.upenn.edu/scxc/

Google Maps Location

cite this facility

Quicklinks:

https://coremarketplace.org/SCXC https://coremarketplace.org/RRID:SCR_010035

Facility LIMS Page

https://med-upenn.corefacilities.org/service_center/show_external/4507

Primary Contact:

scxc@lists.upenn.edu

Last Updated: 02/13/2025

Facility RRID

RRID:SCR_010035

Facility Details

Offers in vivo services specializing in immunodeficient and xenograft models (PDX, humanized immune system). Facility has dedicated BSL2 barrier space equipped with optical imaging, for applications ranging from immunotherapy, cancer biology, infectious diseases and regenerative medicine.

Offers services centered around repository of live and fully annotated cells from adult patients with hematologic malignancies (AML, ALL, MPN, MDS), and hematopoietic stem/progenitor cells from healthy donors (BM, CB, and FL).

Facility Policies

Services are offerred outside of University of Pennsylvania

Consulting is offerred outside of University of Pennsylvania

Services offered:

Animal Husbandry

Bioethics Consultation Support

Xenograft / Xenotransplantation

Facility Equipment

No additional equipment has been listed

Publications

Publications associated with this facility (Click To View):

1.) Alexander KA, Yu R, Skuli N, Coffey NJ, Nguyen S, Faunce CL, Huang H, Dardani IP, Good AL, Lim J, Li CY, Biddle N, Joyce EF, Raj A, Lee D, Keith B, Simon MC, Berger SL (2025 Jan 2). Nuclear speckles regulate functional programs in cancer Nature cell biology, 27(2), 322-335. . PMCID: 12039181.

2.) Hayes BH, Wang M, Zhu H, Phan SH, Dooling LJ, Andrechak JC, Chang AH, Tobin MP, Ontko NM, Marchena T, Discher DE (2024 May 28). Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG eLife, 12(), RP88054. . PMCID: 11132682.

3.) Peramangalam PS, Surapally S, Veltri AJ, Zheng S, Burns R, Zhu N, Rao S, Muller-Tidow C, Bushweller JH, Pulikkan JA (2024 Feb 28). N-MYC regulates cell survival via eIF4G1 in inv(16) acute myeloid leukemia Science Advances, 10(9), eadh8493. . ID: 10901375.

4.) Willis E, Verrelle J, Banerjee E, Assenmacher CA, Tarrant JC, Skuli N, Jacobson ML, O (2024 Jan 10). Humanization with CD34-positive hematopoietic stem cells in NOG-EXL mice results in improved long-term survival and less severe myeloid cell hyperactivation phenotype relative to NSG-SGM3 mice. Veterinary pathology, (), 3009858231222216. doi: 10.1177/03009858231222216. ID: 38197423.

5.) Gitto SB, Whicker M, Davies G, Kumar S, Kinneer K, Xu H, Lewis A, Mamidi S, Medvedev S, Kim H, Anderton J, Tang EJ, Ferman B, Coats S, Wilkinson RW, Brown E, Powell DJ, Simpkins F (2023 Oct 26). A B7-H4 targeting antibody-drug conjugate shows anti-tumor activity in PARPi and platinum resistant cancers with B7-H4 expression. Clinical cancer research : an official journal of the American Association for Cancer Research, (), . doi: 10.1158/1078-0432.CCR-23-1079. ID: 37882675.

6.) Alexander KA, Yu R, Skuli N, Coffey NJ, Nguyen S, Faunce C, Huang H, Dardani IP, Good AL, Lim J, Li C, Biddle N, Joyce EF, Raj A, Lee D, Keith B, Simon MC, Berger SL (2023 Sep 16). Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer bioRxiv, (), 2023.09.14.557228. . PMCID: 10515914.

7.) Lee I, Doepner M, Weissenrieder J, Majer AD, Mercado S, Estell A, Natale CA, Sung PJ, Foskett JK, Carroll MP, Ridky TW (2023 Aug). LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway. Cancer research communications, 3(8), 1594-1606. . ID: 37599786.

8.) Katsuda T, Sussman J, Li J, Merrell AJ, Vostrejs W, Secreto A, Matsuzaki J, Ochiya T, Stanger BZ (2023 Jul 11). Evidence for in vitro extensive proliferation of adult hepatocytes and biliary epithelial cells. Stem cell reports, 18(7), 1436-1450. . ID: 37352852.

9.) Uslu U, June CH (2023 Jul 5). T-cell Therapies Targeting Multiple Cancer Antigens: The Power of Many. Cancer immunology research, 11(7), 865. doi: 10.1158/2326-6066.CIR-23-0160. ID: 37347991.

10.) Zappala F, Higbee-Dempsey E, Jang B, Miller J, Yan L, Minutolo NG, Rosado González GT, Tsourkas A, Ozdemir BA (2022 May 6). Rapid, site-specific labeling of "off-the-shelf" and native serum autoantibodies with T cell-redirecting domains. Science advances, 8(18), eabn4613. . ID: 35522741.

11.) Chaves-Moreira D, Mitchell MA, Arruza C, Rawat P, Sidoli S, Nameki R, Reddy J, Corona RI, Afeyan LK, Klein IA, Ma S, Winterhoff B, Konecny GE, Garcia BA, Brady DC, Lawrenson K, Morin PJ, Drapkin R (2022 Apr 5). The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17. Science signaling, 15(728), eabm2496. . ID: 35380877.

12.) Gitto SB, George E, Medvedev S, Simpkins F, Powell DJ Jr (2022). Humanized Patient-Derived Xenograft Models of Ovarian Cancer. Methods in molecular biology (Clifton, N.J.), 2424(), 255-274. doi: 10.1007/978-1-0716-1956-8_17. ID: 34918300.

13.) Weinfurtner K, Cho J, Ackerman D, Chen JX, Woodard A, Li W, Ostrowski D, Soulen MC, Dagli M, Shamimi-Noori S, Mondschein J, Sudheendra D, Stavropoulos SW, Reddy S, Redmond J, Khaddash T, Jhala D, Siegelman ES, Furth EE, Hunt SJ, Nadolski GJ, Kaplan DE, Gade TPF (2021 Nov 23). Variability in biopsy quality informs translational research applications in hepatocellular carcinoma. Scientific reports, 11(1), 22763. . ID: 34815453.

14.) Roy AG, Robinson JM, Sharma P, Rodriguez-Garcia A, Poussin MA, Nickerson-Nutter C, Powell DJ Jr (2021 May 25). Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy. International journal of molecular sciences, 22(11), . . ID: 34070369.

15.) Rivera OD, Mallory MJ, Quesnel-Vallières M, Chatrikhi R, Schultz DC, Carroll M, Barash Y, Cherry S, Lynch KW (2021 Apr 13). Alternative splicing redefines landscape of commonly mutated genes in acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 118(15), . . ID: 33876749.

16.) Gitto SB, Kim H, Rafail S, Omran DK, Medvedev S, Kinose Y, Rodriguez-Garcia A, Flowers AJ, Xu H, Schwartz LE, Powell DJ Jr, Simpkins F (2020 Jan). An autologous humanized patient-derived-xenograft platform to evaluate immunotherapy in ovarian cancer. Gynecologic oncology, 156(1), 222-232. doi: 10.1016/j.ygyno.2019.10.011. ID: 31818495.

17.) Richman SA, Nunez-Cruz S, Moghimi B, Li LZ, Gershenson ZT, Mourelatos Z, Barrett DM, Grupp SA, Milone MC (2018 Jan). High-Affinity GD2-Specific CAR T Cells Induce Fatal Encephalitis in a Preclinical Neuroblastoma Model. Cancer immunology research, 6(1), 36-46. . ID: 29180536.

Associations

ABRF

Association of Biomolecular Resource Facilities

Metadata

Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=1384
https://coremarketplace.org/RRID:SCR_010035

Institution

Institution ROR ID: https://ror.org/00b30xv10

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

ABRF, USEDit, healthy donor, umbilical, cord, tissue, bank, human, hematopoietic, malignancy, xenograft, service, whole, bone, marrow, blood, sorter, leukemia, imaging

Resource Type:

core facility, material resource, service resource, access service resource, biomaterial supply resource, tissue bank

Citation:

Pennsylvania University Perelman School of Medicine Stem Cell and Xenograft Core Facility (RRID:SCR_010035)

University of Pennsylvania Perelman School of Medicine Stem Cell and Xenograft Core Facility (Oncology (Translational))

Quicklinks:

Facility LIMS Page

Primary Contact:

Facility RRID

Facility Details

Facility Policies

(To see more facility information, click the in the upper right)

Services offered:

Facility Equipment

(To see more facility information, click the in the upper right)

Publications

(To see more facility information, click the in the upper right)

Associations

ABRF

(To see more facility information, click the in the upper right)

Metadata

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Facility Profile QR Code (links to this profile)

(To see more facility information, click the in the upper right)

Contact scxc@lists.upenn.edu

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University of Pennsylvania Perelman School of Medicine Stem Cell and Xenograft Core Facility

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