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Biorepository Core

Geisel School of Medicine at Dartmouth

1 Medical Center Drive

HD 7927, Rubin 7

Lebanon, NH 03756

United States of America

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Primary Contact:

Tom Palys

Last Updated: 09/02/2016

Facility Details

The Center for Molecular Epidemiology Biorepository Core of the Geisel School of Medicine at Dartmouth utilizes a combination of manual and advanced robotic liquid handing processes, as well as traditional and state-of-the art automated archival storage strategies (e.g. ambient temperature, 4°C, -20°C, -80°C, and liquid nitrogen) to provide standardized services to the to members of the research community. The Biorepository manages a broad range of adult, child and infant specimen types, such as blood and its components, urine, nails, meconium, stool, placenta, breastmilk, DNA and RNA, as well as various environmental samples. Specimen processing services include blood fractionation, lymphocyte isolation, aliquoting of specimens for archival storage, human and microbiome nucleic acid extraction, quantification and normalization, tissue separation and fixation, specimen retrieval, shipping and referral management services. The Biorepository Core also plays a critical role in the development of new projects by working with investigators to pilot and establish methods for collection, processing, archiving and subsequent referral of study specimens. The Biorepository has processed roughly over 21,000 adult and infant specimens and archived over 100,000 aliquots. The Biorepository also manages the Dartmouth Biospecimen Storage Facility, a secure, off-site facility dedicated to long term storage of specimens, providing 24 hour/7 day a week, real-time video surveillance, continuous and redundant monitoring of freezer temperatures and emergency response to users.

Other Facility Information

COBRE Biorepository Services

Reagent/Collection Device Preparation Services
Acid washing Collection Containers
Pre-cleaning wipes
Preparation of RNAlater tubes

Specimen Receipt and Management Services
Pre-processing storage
Specimen Check-in Annotation
Specimen Processing/Archiving/Referral Data Management and Auditing

Initial Specimen Processing Services
Blood fractionation (adult, child, infant, cord)
Lymphocyte isolation from blood (adult, cord)
Urine aliquot processing (adult, child, infant)
Urinary Specific Gravity
Urinary Creatinine
Stool Processing (meconium, transitional stool, infant, child, adult)
Placenta and tissue processing (freezing, fixation)
Nail and hair processing
Guthrie Card Processing
Water Aliquot processing

Secondary/Pre-analytical Specimen Processing Services
DNA extraction, quantification and normalization: Genomic (Blood, Buffy Coat, Tissue, FFPE, Saliva, Swabs)
DNA extraction, quantification and normalization: Microbiome (Stool, Skin, Vaginal, Breastmilk, Saliva)
RNA extraction, quantification and normalization: Genomic (Blood, FFPE)
Reformat aliquoting between various storage format (tubes and plates)
Targeted/Map plating
Dilution plating

Post-Processing Services
Specimen Archiving (RT, 4°C, -20°C, -80°C, -150°, LN2)
Specimen Retrieval and Referral
Quality Control
Reference and Quality Control Material Management
Reference and Quality Control Maternal Creation and Characterization
Inclusion in Reference and Quality QC Materials Referrals
Quality Control Reference Material Results Review
Pilot/Study Consultation and Development
Protocol development and Validation

Facility Policies

Services are offerred outside of Geisel School of Medicine at Dartmouth

Consulting is offerred outside of Geisel School of Medicine at Dartmouth