University of Massachusetts Medical School
55 Lake Ave North
Worcester, MA 01655http://umassmed.edu/saicf/index.aspx
Last Updated: 03/02/2012
With the installation of both cameras, the Bioscan NanoSPECT/CT and the Philip Mosaic PET small animal cameras, UMMS and extramural investigators now have the opportunity of using radioactive agents labeled with SPECT radionuclides such as 99mTc, 111In ,123I 125I and PET radionuclides such as 18F, 64Cu, 68Ga, to follow the pharmacokinetics and biodistributions in mice, rats, rabbits, cats and marmoset monkeys and other small animals of proteins, peptides, oligomers, nanoparticles, and other biomarkers of interest. The CT component of the NanoSPECT camera will provide registration for both cameras and, in addition, can be used without radioactivity for high resolution anatomical imaging.
The UMMS Small Animal Imaging Core Facility is now operational and will serve the UMMS and extramural research community by providing state-of-the-art single photon computerized tomography (SPECT), positron emission computerized tomography (PET) and X-Ray computerized tomography (CT) for imaging small animals. The biodistributions of radiolabeled biomarkers of interest such as proteins, peptides, oligomers, nanoparticles, etc. may be followed over time in small animals noninvasively using the Bioscan NanoSPECT/CT camera with single photon radionuclides such as 99mTc, 111In, 123I, 125I and/or with the Philip Mosaic PET camera with positron emitting radionuclides such as 18F, 68Ga, and 64Cu. The accompanying software allows for the accurate quantitation of radioactivity in organs and lesions. The CT component of the NanoSPECT camera will provide registration for both cameras and, in addition, can be used without radioactivity for high resolution anatomical imaging. Please visit our website for additional details. http://umassmed.edu/saicf/index.aspx
The staff and faculty of the Small Animal Imaging Core Facility are committed to providing complete small animal radioactivity imaging capability to researchers within and without the UMMS system. For the present, this includes consultation services to assist researchers in designing imaging studies that are appropriate for their goals, limited radiolabeling services and data acquisition and analysis. In the future, we intend to expand our radiolabeling services to better assist those researchers without the expertise or the interest in radiolabeling of biomarkers. We also intend to expand our data analysis capabilities to provide researchers with more comprehensive final reports adjusted to their needs.
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