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All Facilities >> University at Albany, SUNY >> RNA Epitranscriptomics and Proteomics Resource

RNA Epitranscriptomics and Proteomics Resource

Facility Details

About This Facility

Services and Equipment

Publications

Associations

Metadata

University at Albany, SUNY

1400 Washington Ave

ls1085

Albany, NY 12222

United States of America

http://www.albany.edu/repr

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Quicklinks:

https://coremarketplace.org/RRID:SCR_017695

Primary Contact:

Qishan Lin

Last Updated: 11/09/2020

Facility RRID

RRID:SCR_017695

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Facility Details

The RNA Epitranscriptomics and Proteomics Resource (REPR), built upon the existing Proteomics core facility as well as the RNA Institute Mass Spectrometry Center, is a joint venture between the VPR office and the Dean of the College of Arts and Sciences. This specialized laboratory maintains a comprehensive state-of-the-art mass spectrometry research facility to support a wide range of internal and external research projects. The REPR is dedicated to providing high quality mass spectrometry services in a time and cost-effective manner. We are a full-service provider of both small and large molecule laboratory, training and consulting services with value-added solutions. In addition to supporting the university research enterprise, the REPR also serves the pharmaceutical and biotechnology industries, universities, and government labs.

RNA Epitranscriptomics
The RNA epitranscriptomics services include a comprehensive range of custom services such as RNA purification, RNA characterization, and RNA chemical modification analysis using quantitative mass spectrometry.

Proteomics/Mass Spec
The proteomics/mass spectrometry services include comprehensive targeted and un-targeted metabolomics and proteomics, high resolution mass measurement for both large and small molecules, PK/PD study, bio-similar characterization, ADC characterization, and large-scale characterization of proteins and metabolites expressed in health and disease.

Facility Policies

Services are offerred outside of University at Albany, SUNY

Consulting is offerred outside of University at Albany, SUNY

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Services offered:

Assays and Measurements

Biochemical Analysis

Gel Chromatography

Isothermal Titration Calorimetry (ITC)

Mass Spectrometry

Phosphoproteomics

Protein Extraction/Purification

Sequencing - Protein Sequencing

Shared Instrumentation Oversight & Maintenance

Facility Equipment

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QTRAP6500
Agilent 6530BA
Agilent Q 6120
Thermo Orbitrap XL
UHPLC 1290 1260
Shimadzu Nexera
Waters Accuity I TQ-S
CapLC
Autoflex

(To see more facility information, click the in the upper right)

Publications

Publications associated with this facility (Click To View):

1.) Wu Y, Zheng YY, Lin Q, Sheng J (2020 Sep). Detection and Quantification of RNA Phosphorothioate Modifications Using Mass Spectrometry. Current protocols in nucleic acid chemistry, 82(1), e113. doi: 10.1002/cpnc.113. PMID: 32822120.

2.) Sas-Chen A, Thomas JM, Matzov D, Taoka M, Nance KD, Nir R, Bryson KM, Shachar R, Liman GLS, Burkhart BW, Gamage ST, Nobe Y, Briney CA, Levy MJ, Fuchs RT, Robb GB, Hartmann J, Sharma S, Lin Q, Florens L, Washburn MP, Isobe T, Santangelo TJ, Shalev-Benami M, Meier JL, Schwartz S (2020 Jul). Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature, 583(7817), 638-643. doi: 10.1038/s41586-020-2418-2. PMID: 32555463.

3.) Wu Y, Tang Y, Dong X, Zheng YY, Haruehanroengra P, Mao S, Lin Q, Sheng J (2020 Jun 19). RNA Phosphorothioate Modification in Prokaryotes and Eukaryotes. ACS chemical biology, 15(6), 1301-1305. doi: 10.1021/acschembio.0c00163. PMID: 32275390.

4.) Levy MJ, Montgomery DC, Sardiu ME, Montano JL, Bergholtz SE, Nance KD, Thorpe AL, Fox SD, Lin Q, Andresson T, Florens L, Washburn MP, Meier JL (2020 Mar 19). A Systems Chemoproteomic Analysis of Acyl-CoA/Protein Interaction Networks. Cell chemical biology, 27(3), 322-333.e5. doi: 10.1021/acschembio.0c00163. PMID: 31836350.

5.) Tardu M, Jones JD, Kennedy RT, Lin Q, Koutmou KS (2019 Jul 19). Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs. ACS chemical biology, 14(7), 1403-1409. doi: 10.1021/acschembio.9b00369. PMID: 31243956.

6.) Li W, Yalcin M, Bharali DJ, Lin Q, Godugu K, Fujioka K, Keating KA, Mousa SA (2019 Jun 21). Pharmacokinetics, Biodistribution, and Anti-Angiogenesis Efficacy of Diamino Propane Tetraiodothyroacetic Acid-conjugated Biodegradable Polymeric Nanoparticle. Scientific reports, 9(1), 9006. doi: 10.1038/s41598-019-44979-6. PMID: 31227723.

7.) Dai Y, Weng J, George J, Chen H, Lin Q, Wang J, Royzen M, Zhang Q (2019 May 17). Three-Component Protein Modification Using Mercaptobenzaldehyde Derivatives. Organic letters, 21(10), 3828-3833. doi: 10.1021/acs.orglett.9b01294. PMID: 31058515.

8.) Li Y, Sharma MR, Koripella RK, Yang Y, Kaushal PS, Lin Q, Wade JT, Gray TA, Derbyshire KM, Agrawal RK, Ojha AK (2018 Aug 7). Zinc depletion induces ribosome hibernation in mycobacteria. Proceedings of the National Academy of Sciences of the United States of America, 115(32), 8191-8196. doi: 10.1021/acs.orglett.9b01294. PMID: 30038002.

9.) Mansouri W, Fordyce SB, Wu M, Jones D, Cohn D, Lin Q, Feustel P, Sharma T, Bennett JA, Andersen TT (2018 Apr 15). Efficacy and tolerability of AFPep, a cyclic peptide with anti-breast cancer properties. Toxicology and applied pharmacology, 345(32), 10-18. doi: 10.1021/acs.orglett.9b01294. PMID: 29518411.

10.) Rompala GR, Mounier A, Wolfe CM, Lin Q, Lefterov I, Homanics GE (2018). Heavy Chronic Intermittent Ethanol Exposure Alters Small Noncoding RNAs in Mouse Sperm and Epididymosomes. Frontiers in genetics, 9(32), 32. doi: 10.3389/fgene.2018.00032. PMID: 29472946.

11.) Li Z, Brecher M, Deng YQ, Zhang J, Sakamuru S, Liu B, Huang R, Koetzner CA, Allen CA, Jones SA, Chen H, Zhang NN, Tian M, Gao F, Lin Q, Banavali N, Zhou J, Boles N, Xia M, Kramer LD, Qin CF, Li H (2017 Aug). Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction. Cell research, 27(8), 1046-1064. doi: 10.3389/fgene.2018.00032. PMID: 28685770.

12.) Brecher M, Li Z, Liu B, Zhang J, Koetzner CA, Alifarag A, Jones SA, Lin Q, Kramer LD, Li H (2017 May). A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease. PLoS pathogens, 13(5), e1006411. doi: 10.1371/journal.ppat.1006411. PMID: 28542603.

13.) Li W, Yalcin M, Lin Q, Ardawi MM, Mousa SA (2017 Feb 28). Self-assembly of green tea catechin derivatives in nanoparticles for oral lycopene delivery. Journal of controlled release : official journal of the Controlled Release Society, 248(5), 117-124. doi: 10.1371/journal.ppat.1006411. PMID: 28077264.

14.) Du H, Zhao H, Lai X, Lin Q, Zhu Z, Chai Y, Lou Z (2017 Jul). Metabolic profiles revealed synergistically antidepressant effects of lilies and Rhizoma Anemarrhenae in a rat model of depression. Biomedical chromatography : BMC, 31(7), 117-124. doi: 10.1002/bmc.3923. PMID: 28009452.

15.) Du H, Wang K, Su L, Zhao H, Gao S, Lin Q, Ma X, Zhu B, Dong X, Lou Z (2016 Sep 5). Metabonomic identification of the effects of the Zhimu-Baihe saponins on a chronic unpredictable mild stress-induced rat model of depression. Journal of pharmaceutical and biomedical analysis, 128(7), 469-479. doi: 10.1002/bmc.3923. PMID: 27371920.

16.) Liu S, Zhang Q, Chen C, Ge D, Qu Y, Chen R, Fan YM, Li N, Tang WW, Zhang W, Zhang K, Wang AR, Rowan BG, Hill SM, Sartor O, Abdel-Mageed AB, Myers L, Lin Q, You Z (2016 Mar 22). Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor. Oncotarget, 7(12), 13651-66. doi: 10.1002/bmc.3923. PMID: 26871944.

17.) Wu Q, Lai X, Zhu Z, Hong Z, Dong X, Wang T, Wang H, Lou Z, Lin Q, Guo Z, Chai Y (2015 Aug). Evidence for Chronic Kidney Disease-Mineral and Bone Disorder Associated With Metabolic Pathway Changes. Medicine, 94(32), e1273. doi: 10.1097/MD.0000000000001273. PMID: 26266360.

18.) Lin HY, Haegele JA, Disare MT, Lin Q, Aye Y (2015 May 20). A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling. Journal of the American Chemical Society, 137(19), 6232-44. doi: 10.1021/ja5132648. PMID: 25909755.

19.) Gao S, Chen W, Peng Z, Li N, Su L, Lv D, Li L, Lin Q, Dong X, Guo Z, Lou Z (2015 May 26). Urinary metabonomics elucidate the therapeutic mechanism of Orthosiphon stamineus in mouse crystal-induced kidney injury. Journal of ethnopharmacology, 166(19), 323-32. doi: 10.1021/ja5132648. PMID: 25794803.

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Associations

NERLSCD

Northeast Regional Life Science Core Directors

ABRF

Association of Biomolecular Resource Facilities

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Metadata

Links

All the links listed resolve to this core listing

https://coremarketplace.org/?FacilityID=113
https://coremarketplace.org/RRID:SCR_017695

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

Mass, spectrometry, instrument, analysis, RNA, protein, biomolecule, data, grant, project, service, core

Resource Type:

Resource, service resource, core facility, access service resource

Citation:

Albany University RNA Epitranscriptomics and Proteomics Resource Core Facility (RRID:SCR_017695)

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RNA Epitranscriptomics and Proteomics Resource

Facility Details

About This Facility

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