The Proteomics Core is a research facility that provides mass spectrometry-based analytical support for a broad range of research projects. The Core houses multiple mass spectrometry platforms with complementary ionization capabilities, including EI, APCI, ESI, and MALDI, enabling qualitative and quantitative analysis of diverse sample types across a range of volatility, polarity, and molecular weight.

Several systems are coupled with chromatographic separation platforms, allowing complex mixtures to be separated prior to mass spectrometric analysis. The Core supports research in areas including proteomics, small-molecule analysis, carbohydrate and glycosaminoglycan-related analysis, metabolomics-oriented method development, and drug-discovery-related projects.

A particular strength of the Core is the analysis of complex biomolecules, including proteins, peptides, carbohydrates, and heparin/glycosaminoglycan-related samples. The Core works closely with investigators to evaluate feasibility, develop appropriate workflows, and interpret mass spectrometry data in the context of each project.

The Mass Spectrometry and Analytical Proteomics Core (MSAPL) at KU provides a range of mass-spectrometry (MS) based services including small molecule analysis & quantitation, peptide and protein MW determination.
We also provide many MS-based proteomics services and associated bioinformatics including: global proteome IDs (Discovery) and targeted proteomics, post-translational modification mapping, quantitative proteomics (Label-free; TMT; other labels). We also provide consultation for designing proteomics experiments. In addition to that we also provide thermal protein profiling (TPP) .

The Nuclear Magnetic Resonance (NMR) Research Core provides Rensselaer researchers, in addition to academic and industrial users throughout the community, access to state-of-the-art, ultra-high field NMR instrumentation. The diverse capabilities of the facility are enabled with an array of fixed and broadband tunable probes for solution and solid-state NMR, and resonators and high power gradients for diffusion and magnetic resonance microimaging. The NMR core actively supports research programs including structure determination of small molecules, proteins, carbohydrates, nucleic acids, and macromolecular complexes at atomic resolution, quantitative analysis of complex mixtures, metabolomics applications, diffusion analysis, characterization of materials, and MR microimaging.

Expert training and assistance is available in experiment design and/or pulse sequence customization, sample preparation, data acquisition, processing, analysis, and reporting of results (e.g. manuscript and/or grant preparation) in addition to comprehensive fee-for-service support.

The Microscopy and Analytical Imaging Research Resource Core Laboratory (MAI; also known as
Microscopy and Analytical Imaging Shared Resource [MAISR]), is a 2,450 ft2 core research resource core laboratory in Room 1043 in Haworth Hall at the University of Kansas Lawrence campus. The MAI (https://mai.ku.edu/) is a fee-for-service center. The imaging resources within the MAI are available to all University of Kansas, University of Kansas Medical Center, and University of Kansas Cancer Center students, staff, and faculty, students, staff, and faculty within and outside the state, and industry collaborators working in the life sciences and material sciences for nominal fees.

The MAI resource scientists (https://mai.ku.edu/lab-staff) provides training for undergraduate, graduate students, postdoctoral researchers, faculty, staff, and industry collaborators as many times as is necessary to master a given instrument and/or technique.
The MAI is directed by Eduardo Rosa- Molinar, Ph.D., Professor of Pharmacology and Toxicology, Bicampus Neuroscience Graduate Program, Anatomy and Cell Biology, and Bioengineering.

The KU Protein Production Group (PPG) focuses on the cloning, expression and purification of prokaryotic and eukaryotic proteins for KU and other investigators in Kansas and the nation. The laboratory maintains a variety of equipment to support the production of properly folded proteins in quantities suitable for structural studies (X-ray and NMR), functional studies (catalytic or biological), label-free binding studies (SPR) and/or high throughput (HTP) screening studies.

The Protein Structure & X-Ray Crystallography Laboratory (PSXL) is a core laboratory at the University of Kansas that possesses the infrastructure and expertise to perform all aspects of protein and small molecule structure determination using X-ray crystallography. For protein structure determination, high-throughput methods are utilized to move projects rapidly from gene-to-structure.

The COBRE Biomolecular NMR Laboratory maintains two high field NMR spectrometers in support of structural and dynamics studies of biomolecules with COBRE and other investigators in Kansas and the region. Its capabilities include determining high resolution structures, biological macromolecules, elucidation and structural mapping of protein-protein, protein-nucleic acid, protein-peptide, protein-drug interactions, and studies of the dynamics of proteins and their complexes in solution. Laboratory staff provide advice, consultation, training, assistance and complete structure elucidation services to investigators. The staff is also responsible for maintenance, upgrades, implementation of new NMR pulse sequences, and assisting local and remote users with technical problems.

High throughput screening of large chemical libraries of compounds is a proven way to identify novel chemical entities that target a biological system of interest. KU-HTS is a state- of-the-art facility dedicated to providing exceptional services in advancing drug discovery research initiatives, as well as assistance in preparing grant applications. HTS personnel have extensive experience in executing biochemical, cell-based, siRNA as well as high content screening campaigns against a plethora of target classes. KU-HTS is a fee-for-service facility dedicated to providing academia and nonprofit institutions, as well as the biotech and pharmaceutical industry, with exceptional quality services at the lowest cost structure. We partner with the investigators collaboratively to expedite their drug discovery efforts and serve as a uniquely qualified reference facility with high throughput screening instrument manufacturers as well as reagent kit developers and manufacturers.

The Synthetic Medicinal Chemistry Laboratory is a university-based drug discovery facility with a state-of-the-art infrastructure for pharmaceutical research. The Core provides medicinal, synthetic, and combinatorial chemistry support for Core B (HTS) and COBRE investigators. The support involves the optimization of compounds for potency, and selectivity by the following:

Preparing targeted libraries for screening and
lead optimization
Synthesizing organic compounds on various scales
(from mg to multi-gram)
Assisting COBRE investigators and other
university investigators, if requested, in the
design of novel ligands and in the development
of practical synthetic routes.

Imaging instrumentation:
7T/13cm horizontal and 14T/9cm vertical bore MRI Scanners, Bruker Ultraflex III MALDI TOF/TOF with imaging capabilities and a small animal Scanco Medical Viva CT40 micro-CT scanner

The Analytical Biochemistry Core Facility at RPI is one of the best equipped research facilities in the northeast. This new facility is equipped with state-of-the-art instrumentation.
Instrumentation:Spex® FluoroLog®-Tau -3 Spectrofluorimeter,Jasco 815 Spectrometer with BioLogic stopped-flow,Bruker D8 Discover X-Ray Diffractometer,Bruker Nanostar Small-Angle X-Ray Scattering,Beckman Analytical Ultracentrifuge XL-I,MicroCal VP-Isothermal Titration Calorimeter (VP-ITC),Shimadzu High Pressure Liquid Chromatograph (HPLC,TA DSC Q100,TA TGA Q50,Wyatt Technology DynaPro Titan Batch Dynamic Light Scattering, Analytical Biochemistry Core Facility

Its mission is to provide service and consultation on many different areas of modern analytical biochemistry to both on and off campus investigators.

Instrumentation:
BD Sciences FACSAria,BD Sciences LSRII,GE Typhoon Trio+ ,Roche LightCycler 480 RT-PCR ,Amaxa Nucleofector and much more