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UA CBC Molecular Structures Core (MSC) (Molecular Structure and Modeling)
The Molecular Structures Core (MSC) enables researchers to determine the structures and dynamics, or motions, of large biomolecules such as proteins and DNA to understand how they interact with each other and with small molecules such as drugs.
are offerred outside of University of Arizona
is not offerred outside of University of Arizona Services offered: Facility Equipment
No additional equipment has been listed
Publications associated with this facility (Click To View):
François-Moutal L, Scott DD, Ambrose AJ, Zerio CJ, Rodriguez-Sanchez M, Dissanayake K, May DG, Carlson JM, Barbieri E, Moutal A, Roux KJ, Shorter J, Khanna R, Barmada SJ, McGurk L, Khanna M (2022 May 17). Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology. Scientific reports, 12(1), 8140. doi: 10.1038/s41598-022-12191-8. ID: 35581326.
Francois-Moutal L, Scott DD, Khanna M (2021 Aug 5). Direct targeting of TDP-43, from small molecules to biologics: the therapeutic landscape. RSC chemical biology, 2(4), 1158-1166. doi: 10.1039/d1cb00110h. ID: 34458829.
Schoenle MV, Li Y, Yuan M, Clarkson MW, Wilson IA, Peti W, Page R (2021 Jun 2). NMR Based SARS-CoV-2 Antibody Screening. Journal of the American Chemical Society, 143(21), 7930-7934. doi: 10.1021/jacs.1c03945. ID: 34018723.
Torgeson KR, Clarkson MW, Kumar GS, Page R, Peti W (2020 Oct 2). Cooperative dynamics across distinct structural elements regulate PTP1B activity. The Journal of biological chemistry, 295(40), 13829-13837. . ID: 32737198.
Lixa C, Clarkson MW, Iqbal A, Moon TM, Almeida FCL, Peti W, Pinheiro AS (2019 Oct 15). Retinoic Acid Binding Leads to CRABP2 Rigidification and Dimerization. Biochemistry, 58(41), 4183-4194. doi: 10.1021/acs.biochem.9b00672. ID: 31566355.
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