The CoreMarketplace: CBC Molecular Structures Core (MSC)

The Molecular Structures Core (MSC) enables researchers to determine the structures and dynamics, or motions, of large biomolecules such as proteins and DNA to understand how they interact with each other and with small molecules such as drugs.

Facility Policies

Services are offerred outside of University of Arizona

Consulting is not offerred outside of University of Arizona

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Services offered:

Nuclear Magnetic Resonance (NMR)

Protein NMR

Facility Equipment

No additional equipment has been listed

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Publications

Publications associated with this facility (Click To View):

1.) Koss KM, Sereda TJ, Kumirov VK, Wertheim JA (2023 May 11). A class of peptides designed to replicate and enhance the Receptor for Hyaluronic Acid Mediated Motility binding domain. Acta biomaterialia, (), . pii: S1742-7061(23)00251-9. doi: 10.1016/j.actbio.2023.05.009. ID: 37178990.

2.) Ambrose AJ, Sivinski J, Zerio CJ, Zhu X, Godek J, Kumirov VK, Coma Brujas T, Torra Garcia J, Annadurai A, Schmidlin CJ, Werner A, Shi T, Zavareh RB, Lairson L, Zhang DD, Chapman E (2023 Jan 12). Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78. Journal of medicinal chemistry, 66(1), 677-694. doi: 10.1021/acs.jmedchem.2c01631. ID: 36516003.

3.) Torgeson KR, Clarkson MW, Granata D, Lindorff-Larsen K, Page R, Peti W (2022 Aug 5). Conserved conformational dynamics determine enzyme activity. Science advances, 8(31), eabo5546. . ID: 35921420.

4.) Zhang R, Kumar GS, Hansen U, Zoccheddu M, Sacchetti C, Holmes ZJ, Lee MC, Beckmann D, Wen Y, Mikulski Z, Yang S, Santelli E, Page R, Boin F, Peti W, Bottini N (2022 Apr 22). Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex. JCI insight, 7(8), . . ID: 35451370.

5.) Vos MR, Piraino B, LaBreck CJ, Rahmani N, Trebino CE, Schoenle M, Peti W, Camberg JL, Page R (2022 Feb). Degradation of the E. coli antitoxin MqsA by the proteolytic complex ClpXP is regulated by zinc occupancy and oxidation. The Journal of biological chemistry, 298(2), 101557. . ID: 34974059.

6.) Singh JP, Li Y, Chen YY, Hsu SD, Page R, Peti W, Meng TC (2022 Jan 10). The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1. Nature communications, 13(1), 94. . ID: 35013194.

7.) Fowle H, Zhao Z, Xu Q, Wasserman JS, Wang X, Adeyemi M, Feiser F, Kurimchak AN, Atar D, McEwan BC, Kettenbach AN, Page R, Peti W, Dunbrack RL, Graña X (2021 Oct 18). PP2A/B55α substrate recruitment as defined by the retinoblastoma-related protein p107. eLife, 10(), . . ID: 34661528.

8.) Schoenle MV, Li Y, Yuan M, Clarkson MW, Wilson IA, Peti W, Page R (2021 Jun 2). NMR Based SARS-CoV-2 Antibody Screening. Journal of the American Chemical Society, 143(21), 7930-7934. doi: 10.1021/jacs.1c03945. ID: 34018723.

9.) Kirsch K, Zeke A, Tőke O, Sok P, Sethi A, Sebő A, Kumar GS, Egri P, Póti ÁL, Gooley P, Peti W, Bento I, Alexa A, Reményi A (2020 Nov 13). Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38. Nature communications, 11(1), 5769. . ID: 33188182.

10.) Torgeson KR, Clarkson MW, Kumar GS, Page R, Peti W (2020 Oct 2). Cooperative dynamics across distinct structural elements regulate PTP1B activity. The Journal of biological chemistry, 295(40), 13829-13837. . ID: 32737198.

11.) Li Y, Sheftic SR, Grigoriu S, Schwieters CD, Page R, Peti W (2020 Jul). The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin. Science advances, 6(27), . . ID: 32936779.

12.) Wang X, Garvanska DH, Nasa I, Ueki Y, Zhang G, Kettenbach AN, Peti W, Nilsson J, Page R (2020 Mar 20). A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment. eLife, 9(), . . ID: 32195664.

13.) Kump KJ, Miao L, Mady ASA, Ansari NH, Shrestha UK, Yang Y, Pal M, Liao C, Perdih A, Abulwerdi FA, Chinnaswamy K, Meagher JL, Carlson JM, Khanna M, Stuckey JA, Nikolovska-Coleska Z (2020 Mar 12). Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. Journal of medicinal chemistry, 63(5), 2489-2510. . ID: 31971799.

14.) Kumar GS, Page R, Peti W (2020). The mode of action of the Protein tyrosine phosphatase 1B inhibitor Ertiprotafib. PloS one, 15(10), e0240044. . ID: 33007022.

15.) Lixa C, Clarkson MW, Iqbal A, Moon TM, Almeida FCL, Peti W, Pinheiro AS (2019 Oct 15). Retinoic Acid Binding Leads to CRABP2 Rigidification and Dimerization. Biochemistry, 58(41), 4183-4194. doi: 10.1021/acs.biochem.9b00672. ID: 31566355.

16.) François-Moutal L, Felemban R, Scott DD, Sayegh MR, Miranda VG, Perez-Miller S, Khanna R, Gokhale V, Zarnescu DC, Khanna M (2019 Sep 20). Small Molecule Targeting TDP-43 ACS chemical biology, 14(9), 2006-2013. . ID: 31241884.

17.) Hendus-Altenburger R, Wang X, Sjøgaard-Frich LM, Pedraz-Cuesta E, Sheftic SR, Bendsøe AH, Page R, Kragelund BB, Pedersen SF, Peti W (2019 Aug 2). Molecular basis for the binding and selective dephosphorylation of Na(+)/H(+) exchanger 1 by calcineurin. Nature communications, 10(1), 3489. . ID: 31375679.

18.) Scott DD, Francois-Moutal L, Kumirov VK, Khanna M (2019 Apr). (1)H, (15)N and (13)C backbone assignment of apo TDP-43 RNA recognition motifs. Biomolecular NMR assignments, 13(1), 163-167. doi: 10.1007/s12104-018-09870-x. ID: 30694439.

19.) Bertran MT, Mouilleron S, Zhou Y, Bajaj R, Uliana F, Kumar GS, van Drogen A, Lee R, Banerjee JJ, Hauri S, O (2019 Feb 15). ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail. Nature communications, 10(1), 771. . ID: 30770806.

20.) Kumar GS, Choy MS, Koveal DM, Lorinsky MK, Lyons SP, Kettenbach AN, Page R, Peti W (2018 Nov). Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme. Science advances, 4(11), eaau6044. . ID: 30443599.

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Associations

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Metadata

Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=1585
https://coremarketplace.org/RRID:SCR_022888

Institution

Institution ROR ID: https://ror.org/03m2x1q45

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

USEDit, ABRF, determine structures and dynamics, determine motions, large biomolecules, small molecules interaction

CBC Molecular Structures Core (MSC) (Molecular Structure and Modeling)

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Facility Details

Facility Policies

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Services offered:

Facility Equipment

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Publications

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Associations

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Metadata

SciCrunch Data Imports (data maintained by https://scicrunch.org)

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Contact Muhammed Shafeek O.H.

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CBC Molecular Structures Core (MSC)

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