Human Disease Models Core Facility produces mice harboring a human immune system (HIS mice) and provide expertise for the possible applications of this model.

HIS mice engrafted with human Hematopoietic stem cells (HSC) are advantageous in vivo models for long-term studies in the field of human immune cells biology, immune-oncology and infectious disease. They constitute a small animal model in which to analyze potency and safety of new drugs modulating the immune system.

The Centre of Biophysics of Macromolecules and their Interactions (french acronym: PFBMI) federates an ensemble of state-of-the-art instrumentation for the in vitro molecular-scale characterization of biological macromolecules, together with well established technical and methodological expertise. The mission of the PFBMI is to provide an added value to a great variety of biological projects,allowing to characterize the intrinsic properties of macromolecules and their assemblies (shape, folding, stability auto-association,and of the interactions in which they are involved (stoichiometry,thermodynamic and kinetic parameters, ...).

Core facility ICV–iPS proposes the generation and the genetic engineering of human induced pluripotent stem cells to internal research teams, external academic teams, and industrial partners. Services include Generation of human iPSc, Full molecular and functional characterization of iPSc clones, Genetic engineering of human iPSc, Generation of human iPS-derived neural stem cells, Theoretical and practical learning sessions on human iPSc culture. Provides access to L2 cell culture box dedicated to human iPSc culture.

Core provides expertise in optical microscopy, electron microscopy, and image analysis for neuroscience research. The platform is open to all researchers. Offers access to advanced technologies, including electron microscopy, confocal microscopy, two-photon imaging, and super-resolution microscopy.

Core develops solutions to meet your needs in electrophysiology data. Provides electrophysiology services to the neuroscience scientific community. Core has standard recording equipment such as patch clamp techniques or electroencephalographic (EEG) recordings.

Core facility dedicated to the study of human cognition and normal and pathological human behavior either via computer tests or in simulations, including using virtual reality.