Human Disease Models Core Facility produces mice harboring a human immune system (HIS mice) and provide expertise for the possible applications of this model.

HIS mice engrafted with human Hematopoietic stem cells (HSC) are advantageous in vivo models for long-term studies in the field of human immune cells biology, immune-oncology and infectious disease. They constitute a small animal model in which to analyze potency and safety of new drugs modulating the immune system.

The Centre of Biophysics of Macromolecules and their Interactions (french acronym: PFBMI) federates an ensemble of state-of-the-art instrumentation for the in vitro molecular-scale characterization of biological macromolecules, together with well established technical and methodological expertise. The mission of the PFBMI is to provide an added value to a great variety of biological projects,allowing to characterize the intrinsic properties of macromolecules and their assemblies (shape, folding, stability auto-association,and of the interactions in which they are involved (stoichiometry,thermodynamic and kinetic parameters, ...).

Core specializes in advanced analysis of proteins to investigate brain functions and neurological disorders. Provides equipment to study protein structure, interactions, and modifications. Services include Mass Spectrometry and Advanced Analysis, Protein Production and Engineering, Amplification of Misfolding Proteins, Highly Sensitive Multiplexed Immunodetection, Sample Preparation and Fractionation.

Core provides infrastructure (A1 and A2 zoned) and technical expertise for standardized husbandry, breeding, experimental use of rodent and health monitoring (SPF and SOPF zones) in compliance with regulatory and ethical guidelines. The platform offers technical services such as Surgery on brain and spinal cord, Behavioral tests (anxiety, depression, cognition, motor/locomotor and visual parameters, spontaneous activity, USV recording etc… ), embryo transfer. Training and technical support are available for rodent handling, experimental design, and data reproducibility.

Core provides support for research teams using non-human primate models in scientific projects. It combines specialized biomedical infrastructure, neuroscience expertise, regulatory guidance and qualified technical staff to ensure the housing, monitoring, handling and experimental use of monkeys in accordance with ethical and regulatory standards. It offers technical support for experimental procedures (A2 facility, several imaging techniques), behavioral training, and neurophysiological investigations as well as gene and cell therapy projects (in collaboration with PBI’s TIDU GENOV unit).

Core offers workspaces and equipment for your histology techniques, as well as advice, training, and services.

Facility provides infrastructure and technical expertise for maintenance, breeding, and experimental use of Danio rerio. The facility ensures standardized husbandry, health monitoring, and traceability of zebrafish lines in compliance with regulatory and ethical guidelines. Services include colony management, maintenance and distribution of wild-type, mutant, and transgenic lines, and support for experimental workflows. The platform offers technical services such as embryo microinjection (e.g., genome editing using CRISPR/Cas9), phenotypic screening, fin clipping for genotyping, and in vitro fertilization. Training and technical support are available for zebrafish handling, experimental design, and data reproducibility.

Vectorology Core Facility (part of the Cellular Engineering and Vectorology platform) provides specialized, high-level expertise, tools, and services for designing, producing, and validating viral vectors used in neuroscience research and gene therapy development. It supports academic and industrial partners by generating modified, safe viral vectors (e.g., AAV, lentivirus) for gene transfer and cellular, including human iPS, engineering.

Core facility provides infrastructure and services to academic researchers, biotech companies and industry partners that need vectors or cell culture models for their studies.
Focuses on generating cell models, genetic modification, viral vector development, and advanced flow cytometry analysis.

Core facility ICV–iPS proposes the generation and the genetic engineering of human induced pluripotent stem cells to internal research teams, external academic teams, and industrial partners. Services include Generation of human iPSc, Full molecular and functional characterization of iPSc clones, Genetic engineering of human iPSc, Generation of human iPS-derived neural stem cells, Theoretical and practical learning sessions on human iPSc culture. Provides access to L2 cell culture box dedicated to human iPSc culture.

Core provides expertise in optical microscopy, electron microscopy, and image analysis for neuroscience research. The platform is open to all researchers. Offers access to advanced technologies, including electron microscopy, confocal microscopy, two-photon imaging, and super-resolution microscopy.

Core develops solutions to meet your needs in electrophysiology data. Provides electrophysiology services to the neuroscience scientific community. Core has standard recording equipment such as patch clamp techniques or electroencephalographic (EEG) recordings.

Core facility dedicated to the study of human cognition and normal and pathological human behavior either via computer tests or in simulations, including using virtual reality.