Facility Details

Established in July 2022, the UC Center for Advanced Structural Biology (CASB) is integrating the latest technology in single-particle cryogenic electron microscopy (cryo-EM). A Thermo Scientific Talos L120C Transmission Electron Microscope (TEM) is available for visualizing nanoparticles, negatively stained proteins or conventional biological samples. It can be operated at 80kV or 120kV.
A Thermo Scientific Glacios 200 kV cryogenic TEM is equipped with both a Ceta-16M camera and a TFS Falcon 4 direct electron detector, in addition to a Selectris Energy Filter. This system is able to generate images for atomic resolution structures for single particle analysis projects. The Glacios also includes software for micro-Electron Diffraction data set collection.

Services Available:
Training and access to the Mark IV Vitrobot plunge freezer
Training and access to the Talos L120C TEM system
Training and access to the Glacios 200 kV cryogenic TEM system
Assisted TEM analysis by CASB personnel (inquiry required)