The CoreMarketplace: Transgenic Animal and Genome Editing Facility

The Transgenic Animal and Genome Editing (TAGE) Facility was established in 1994 as the first shared facility at CCHMC. Since then, we have completed hundreds of chimeric mouse projects and thousands of transgenic lines in mice and rabbits.

(To see more facility information, click the in the upper right)

Services offered:

Facility Equipment

No additional equipment has been listed

(To see more facility information, click the in the upper right)

Publications

Publications associated with this facility (Click To View):

1.) Inskeep KA, Crase B, Dayarathna T, Stottmann RW (2024 Nov 15). SMPD4-mediated sphingolipid metabolism regulates brain and primary cilia development Development (Cambridge, England), 151(22), dev202645. . PMCID: 11586524.

2.) Al Reza H, Santangelo C, Al Reza A, Iwasawa K, Sachiko S, Glaser K, Bondoc A, Merola J, Takebe T (2024 Aug 30). Self-Assembled Generation of Multi-zonal Liver Organoids from Human Pluripotent Stem Cells bioRxiv, (), 2024.08.30.610426. . PMCID: 11384014.

3.) Michaels JR, Husami A, Vontell AM, Brugmann SA, Stottmann RW (2024 Apr 11). Genetic Analysis and Functional Assessment of a TGFBR2 Variant in Micrognathia and Cleft Palate bioRxiv, (), 2024.04.08.588524. . PMCID: 11030355.

4.) Inskeep KA, Crase B, Stottmann RW (2023 Dec 16). SMPD4 mediated sphingolipid metabolism regulates brain and primary cilia development. bioRxiv : the preprint server for biology, (), . . PMID: 38168190.

5.) Pode-Shakked N, Slack M, Sundaram N, Schreiber R, McCracken KW, Dekel B, Helmrath M, Kopan R (2023 Dec 9). RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. Nature communications, 14(1), 8159. . PMID: 38071212.

6.) Múnera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley HA, Zhang X, Sundaram N, Hudson JR, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence JR, Hachimi M, North T, Daley GQ, Mayhew CN, Hu YC, Takebe T, Helmrath MA, Wells JM (2023 Nov 2). Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon Cell stem cell, 30(11), 1434-1451.e9. . PMCID: 10913028.

7.) Reza HA, Farooqui Z, Reza AA, Conroy C, Iwasawa K, Ogura Y, Okita K, Osafune K, Takebe T (2023 Oct 12). Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids Stem Cell Reports, 18(11), 2071-2083. . PMCID: 10679658.

8.) Witcher PC, Sun C, Millay DP (2023 May 1). Expression of Myomaker and Myomerger in myofibers causes muscle pathology Skeletal Muscle, 13(), 8. . PMCID: 10150476.

9.) Liegel RP, Michalski MN, Vaidya S, Bittermann E, Finnerty E, Menke CA, Diegel CR, Zhong ZA, Williams BO, Stottmann RW (2023 Feb 15). Successful therapeutic intervention in new mouse models of frizzled 2-associated congenital malformations Development (Cambridge, England), 150(3), dev201038. . PMCID: 10112907.

(To see more facility information, click the in the upper right)

Associations

(To see more facility information, click the in the upper right)

Metadata

Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=1491
https://coremarketplace.org/RRID:SCR_022642

Institution

Institution ROR ID: https://ror.org/01hcyya48

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

USEDit, ABRF, CRISPR services, gene edited rodents and cells generation, transgenic and chimeric mice generation

Resource Type:

service resource, access service resource, core facility

Citation:

Cincinnati Children's Hospital Transgenic Animal and Genome Editing Core Facility (RRID:SCR_022642)

Transgenic Animal and Genome Editing Facility (Transgenics)

Primary Contact:

Facility RRID

Facility Details

(To see more facility information, click the in the upper right)

Services offered:

Facility Equipment

(To see more facility information, click the in the upper right)

Publications

(To see more facility information, click the in the upper right)

Associations

(To see more facility information, click the in the upper right)

Metadata

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Facility Profile QR Code (links to this profile)

(To see more facility information, click the in the upper right)

Contact Yueh-Chiang Hu

Contact The CoreMarketplace

Transgenic Animal and Genome Editing Facility

The CoreMarketplace is possible in part by collaborations with: