Nucleic Acid Therapeutics Core accelerates the development of gene-targeted therapies by providing custom oligonucleotide synthesis, expert consultation, and platform for cross-disciplinary collaboration.

Core provides research services in custom monoclonal antibody development (mAb) and bulk production of monoclonal antibodies from established hybridomas (somatic cell hybrids). Core has developed monoclonal antibodies against a wide variety of lymphocyte surface antigens, tumor cell antigens, purified proteins, hormones, hormone receptors and recombinant proteins and peptides.

Core provides access to and support for advanced computing resources including high performance computing, active and archive storage, cloud computing, and secure computing environments for sensitive data.

Core with mission to harness data and expertise to power innovations that improve people’s health through unification and enhancement of interdisciplinary efforts at the intersection of artificial intelligence (AI) and health at the University of Michigan. Provides data services, secure computing resources, support to strategically integrate and study AI models in clinical workflows at Michigan Medicine.

Core staff provides personalized consultations, knowledge and resources focused on helping investigators leverage secondary data to advance their mental health research.
Offers consultations and guide in areas:Identifying secondary data sources for mental health studies,Data preparation (e.g., merging/appending data, preparing variables for analysis), Developing analysis plan, including pre-registration, Statistical analysis.

Core provides University of Michigan investigators with guidance and resources needed to utilize mobile technologies and digital mental health measures in their studies. Our experienced faculty and staff offer hands-on consultative services to U-M investigators, regardless of research focus.

Core to enable the use of primary human tissue models for discovery, translation and regenerative medicine.

Core provides annotated biospecimens for basic, clinical, and translational research. Helps researchers access, collect, manage, and protect biospecimens using automated processes and quality control. Offers safe and monitored management of biospecimens including temperature-controlled storage, preparation of derivatives from these specimens, aliquoting, distribution, and production of specimen collection kits.

Core offers sample analysis and experiment design, market assessment and FDA regulation, facilitate interactions for intellectual property protection and support submission of translational grant applications within University of Michigan and government agencies.

Core utilizes Akoya PhenoCycler-Fusion to enable high-plex spatial phenotyping of whole tissue slides at single-cell resolution.

Provides expertise through experimental design consultations,cell isolation,single cell analytics (RNA, DNA, protein),biomarker validation,novel statistical and bioinformatics analyses. Services include Single cell targeted gene expression, Single cell RNA Seq, Single cell DNA Seq, Tissue sectioning, Tissue spatial analysis, Spatial transcriptomics and proteomics.

Core provides microbial sequencing, high-throughput nucleic acid extraction, microbial cultivation, and strain identification.

NMR Facility provides qualified students and researchers in the Chemistry Department access to state-of-the-art NMR instrumentation. Provides support for variety of NMR studies including structure, conformation, dynamics, kinetics and reaction mechanisms of small organic and inorganic molecules and pharmaceuticals.

Core is unit of Department of Epidemiology at the University of Michigan’s School of Public Health. Offers support for clinical research projects throughout process of gathering samples, storing them, and coordinating the assay of the desired analytes. Offers collection kit designs tailor-made to your research study, with tubes and components labeled clearly with barcoded labels and unique sample IDs. Once collected, samples can be processed and stored in one of our 51 on-site ultra-low freezers or in our liquid nitrogen freezer, where their temperatures will be monitored 24/7. When all of the samples are collected, we can complete any combination of 40 different routine assays on them. We currently offer testing using ELISA plates, open channel chemistry analyzer, and coagulation analyzer.

Core routinely generates patient-specific human induced pluripotent stem cells (hiPSCs) for basic science research purposes. Focus is on cardiovascular cell differentiation of hiPSCs to generate unlimited supplies of patient specific cardiovascular cells for in vitro research. Basic services include:hiPSC derivation, hiPSC characterization, hiPSC expanstion;hiPSC differentiation to: Cardiomyocytes, Endothelial Cells, Vascular Smooth Muscle Cells, Pancreatic Cells;3D organoids: Cardiac, Pancreatic;Cardiotoxicity Screening-Drug Discovery Projects;Arrhythmia Testing;High Content Time Lapse Imaging.

Core is part of the University of Michigan Rogel Cancer Center. Provides Rogel Cancer Center investigators with assistance in all quantitative aspects of cancer research -- including biostatistics, bioinformatics, computational biology, analytics and other emerging data-driven and data-intense endeavors.

Core facility provides nascent RNA sequencing using four techniques: Bru-seq, BruChase-seq, BruUV-seq, and BruDRB-seq. This service is all-inclusive, starting with cells and ending with basic data analysis. In addition, users will have access to our exclusive pipeline to perform further data analysis. Our areas of expertise are RNA isolation, cDNA library preparation, and sequencing data analysis.

Core is dedicated to protein analysis and applying mass spectrometry-based proteomic approaches to varied biological questions.

Offers microscopy instrumentation and services. Offers support and training on variety of high-end instrumentation and advanced methodologies for both light and electron microscopy, sample preparation services for electron microscopy, training and assistance with image analysis. Provides support across variety of open-source and commercial image analysis software packages.

Offers full-service sample analysis to measure concentrations of small molecules in biological samples. Services include targeted and untargeted metabolomic screening, method development to explore novel metabolic pathways and systems. Staff helps with interpretation and visualization of your data, and the preparation of grants, proposals, and manuscripts.

Core provides resources and services to prepare samples for analysis in epigenetic regulation in both genome-wide and locus-specific manners.

Flow Cytometry Core provides instrumentation, expertise and services. Samples are prepared by individual investigators, who then deliver to the Core for flow cytometric analysis or cell sorting. The Core also provides assistance in grant and publication preparation, publication-quality graphics, and the development of experimental designs.

Microscopy core facility that provides university researchers with imaging and manipulation tools to detect, track, manipulate, and analyze biomolecules. Offers training and data acquisition support as well as experienced consultation on experimental design and analysis.

Facility performs stable isotope and elemental analyses that support research in climate change, geology, oceanography, and paleontology.

Provides facilities for (U-Th)/He thermochronology on variety of accessory minerals, including apatite, sphene, monazite and zircon. The low closure temperature of the (U-Th)/He system in these minerals makes it ideal for application to geological problems in geomorphology, surface processes, tectonics, structural geology, basin evolution, and thermal maturation.

Core consists of services relating to procurement and evaluation of tissue for research: Tissue Procurement, Histology, and Molecular Pathology. Provides pathology-sanctioned procurement of surgically resected neoplastic and non-neoplastic tissue (fresh and frozen), sample processing, embedding, sectioning, routine H and E, special staining, and immunohistochemistry. Molecular Pathology Research Laboratory performs immunohistochemistry, in-situ hybridization, multiplex immunofluorescence, FISH staining, and tissue microarray construction.

Full-service battery cell fabrication and testing facility open to any academic or industry user.The lab is an IP-protected safe zone to prototype, test, scale-up, and analyze batteries and the materials that go into them.

Core mission is to advance environmental field research, engage students in scientific discovery, and provide information needed to understand and sustain ecosystems from local to global scales. Seek solutions to critical environmental challenges.

Design and synthesize drug-like molecules and diagnostic probes in your biomedical investigations to translate your research in all therapeutic areas and disease states.

Core is part of Unit for Laboratory Animal Medicine. Provides services to perform sterile, minimally-invasive, and non-sterile surgical procedures on both small and large animals.
Facility personnel are licensed veterinary technicians and AALAS Technologists.ULAM Veterinary Board-Certified Surgeon also oversees daily operations.Users must have an approved animal use protocol from the Institutional Animal Care & Use Committee (IACUC) prior to utilizing ASOR services and facilities.

ABSL3 core is specialized in environments designed to facilitate safe research with Risk Group-3 microbial pathogens, which pose significant risk of airborne transmission and serious disease. Core safe for conducting high-level infectious disease research.

Core offers services and instrumentation including Renishaw inVia microscopes,
High sensitivity ultra low noise RenCam CCD detector,Multiple lasers on hand (532nm, 633nm, 785nm),< 1 cm-1 spectral resolution capability. Supports sampling accessories such as fiber optic probes and temperature control stages (liq. He – 300ºC). Offers Automated XYZ stage with 100nm positioning control and Compositional mapping.

Core offers partnership options, including collaboration, fee-for-service and self-service. Helps to discover new medicines, obtain research funding, file patent applications and publish academic research findings. Offers to analyze drug/compound concentration in biological specimens and develop assays.

Core provides instruments including Becton-Dickinson FACSCelesta or ACEA NovoCyte flow cytometer for use after training . Pathology core staff member is assigned to support instruments, answer questions, and, offer on-demand hardware, software, fluidics and technical expertise. Instrument users must ultimately run their own samples and be responsible for technical and scientific legitimacy of their experiments.

Core offers instruments including Reichert-Jung Polycut microtome for decalcified or undecalcified samples, Reichert-Jung rotary microtomes for decalcified specimens, diamond band saws, cryostats for frozen sections with special features for bone section, slow speed diamond saws, high speed grinding cutoff wheel, precision grinding and polishing machines (Buehler Automet 300),complete embedding and preparation equipment and supplies for paraffin, methacrylate, epoxy, and other resins for embedding of biologic specimens, automated tissue processor for plastic and paraffin embedding preparation (Leica ASP 300S)

Core identifies bio-markers using medical imaging that provides insight into disease processes, treatment options, and outcome variability.

Core allows researchers to generate high resolution tomographic data of bone, fossils, and contrast enhanced tissues. These data can include 3D surface visualizations of anatomy and morphology, that can facilitate morphometric studies, phylogenetics analysis, and biomechanics modelling.

Core provides services for acquiring three-dimensional imaging and quantitative analysis of biological and engineered structures/materials. The core is capable of imaging mineralized tissues (e.g., bone, teeth) and soft tissues (e.g., tendons, ligaments, cartilage, blood vessels, muscle) with the aid of radiographic contrast agents. This core is managed and operated by members of the Orthopaedic Research Laboratories.

Core accommodates mass spectrometers (ICP-MS) – Quadrupole ICP-MS and High-Resolution ICP-MS. Provides solution-based elemental analysis on variety of materials from rock through to natural waters in concentration ranges from ppm to ppt in biological, environmental, geological and industrial materials.

Facility dedicated to micron and nanoscale imaging and analysis of materials. The center, housed in Building 22 of the North Campus Research Complex, provides instruments and professional training.

Islet Core provides consultative advice and equipment and services for isolation and study of pancreatic islet structure and function in support of diabetes-related research.

Core supports investigators interested in assays related to diabetes, heart disease, and hypertension. Analytical methods include general blood chemistry, chemiluminescence, immunoassay, radioimmunoassay, multiplexing, and ELISA.

MCDB Imaging Facility in the Biological Sciences Building provides microscopes available to any University of Michigan researcher. Access to scope time granted after appropriate training. Provides microscope equipment, image capture systems, software to assist researchers with their sample imaging.

Core dedicated to developing technology to harness abundant, clean, and renewable marine energy in environmentally sustainable way and at competitive cost.

Research facility dedicated to the study and testing of various marine and hydrodynamic phenomena. It is part of the Department of Naval Architecture and Marine Engineering at the University of Michigan. Conducts research and experiments related to fluid dynamics, ship design, offshore engineering, and other areas relevant to marine and naval architecture.

Lurie Nanofabrication Facility serves technology educators and creators through broad access to advanced nanofabrication equipment and staff expertise in safe, collaborative environment. Equipment and processes are available for research on silicon integrated circuits, MEMS, III-V compound devices, organic devices and nanoimprint technology. We also encourage researchers from non-traditional disciplines to make use of our processes, such as metal and dielectric coatings, vacuum processes, fabrication of micro and nano components and metrology tools.

Core specializes in precise measurements of rare isotopologues such as “clumped” isotopes of carbonate and CO2 and triple oxygen isotope distributions in waters, carbonates, phosphates and recently organics. Houses Nu Perspective IRMS mass spectrometers, EuroVector EA3000 and HT-PyrOH, NuCarb device for traditional carbon and oxygen isotopes, Thermo Fisher ISQ 7000 GC-MS, fully automated clumped isotope preparation line, semi-automated triple oxygen isotope preparation line, manual water fluorination line, multi-purpose vacuum extraction line, and ovens, balances, glassware, fume hoods, and other equipment used in experiments and sample preparation.

Core offers mass spectrometry services. Provided instruments include

Core provides facility to conduct experimental research on neutron irradiated materials in aqueous environments. The IMTL consists of five refreshed autoclaves that can be mounted in constant extension rate or crack growth rate configurations. Capable of conducting experiments on stress corrosion cracking of neutron irradiated material in supercritical water.

Laboratory is part of the Department of Nuclear Engineering and Radiological Sciences in the College of Engineering. MIBL is part of the National Nanotechnology Infrastructure Network. Services involve advancing our understanding of ion-solid interactions. Provides instruments for conducting ion beam surface modification and ion beam surface analysis under range of conditions. Experiments can be conducted at high or low temperature, in ultra-high vacuums, in reactive gas and in short turnaround times.

Core supports neuroscience research using stem cell and gene editing technologies. Full service facility. Provides neuroscience research community valuable new sources of human pluripotent stem cells (hPSCs) for basic research, drug discovery, or cell therapy. Offers services including derivation of induced pluripotent stem cells from fibroblasts or blood cells, CRISPR/Cas9-mediated gene editing hPSCs, monolayer differentiation of hPSCs, cerebral organoid differentiation of hPSCs, and training for hPSC maintenance.

Human Research 3 Tesla Magnetic Resonance Imaging provides high quality anatomic and advanced MR imaging services for IRB-approved research studies and clinical trials with funds allocated for non-standard-of-care research MRI scans.

Simulation lab that is designed as home. Provides space to researchers who want to observe participant behavior in more realistic environment. Offers environment that feels authentic and natural to human condition.

Facility to conduct experimental research on corrosion, stress corrosion cracking, and hydrogen embrittlement experiments in high temperature aqueous and gas environments and, in particular, simulated light water reactor environments. Conducts both high and low temperature corrosion, stress corrosion cracking experiments, electrochemical tests and mechanical tests. Consists of refreshed autoclave systems (titanium, Inconel, or stainless steel construction), mounted in constant extension rate machines and constant load machine. Experiments can be done in range of environments, including supercritical water, simulated BWR and PWR water, high temperature steam, and gas environments. Each autoclave is isolated from the other systems with independent water and computer monitoring systems. The lab also contains two full-featured corrosion measurement systems and additional potentiostats.

Interdisciplinary unit organized under University of Michigan's Medical School - Department of Radiology, dedicated to supporting research on structures and functions of brain that underlie cognitive and affective processes, and research on functional MRI and associated research tools. Provides equipped physical facility and intellectual support services for investigators.

EMAL is part of University of Michigan’s School of Earth and Environmental Sciences. Houses CAMECA SX100 electron microprobes, Rigaku X-ray diffractometers, and JEOL JSM-7800FLV field-emission scanning electron microscope. These instruments are used by researchers for chemical and structural characterization of solid materials.

Performs scanning on per-request basis; maintains secure database of scanned images and associated metadata; instructs and provides technical support to faculty and staff for DP use; supports of live-view microscopy for frozen sections and testing and validation of new whole-slide imaging solutions.

Molecular Biology Core (MBC) is School of Dentistry core and provides real-time quantitative PCR service (ABI ViiA7, ABI-7500 instruments), methodology, technique and experiment design consultation, analytical software training, data analysis, statistics and result interpretation assistance

Core offers services and instruments. Offers Scanco μCT 100 micro-computed tomography system which provides high resolution scans of radio opaque specimens such as bone, contrasted soft tissue, bio materials, etc.

Histology core facility at the University of Michigan School of Dentistry provides histological services using standard histological techniques. The core specializes in sectioning of hard (demineralized) tissues.

CyTOF Core shares equipment and expertise with researchers. Provided instruments include: Helios CyTOF System (Suspension CyTOF), Hyperion CyTOF System (Imaging CyTOF), Attune Flow Cytometer, ÄKTA Pure FPLC, NanoDrop 2000c Spectrophotometer. Offered services include Human immune profiling panel for 29-color analysis of cells in suspension; Mouse immune profiling panel for 16-color analysis of cells in suspension; Custom CyTOF antibody conjugation; Data acquisition of cells in suspension using Helios CyTOF; Image acquisition of tissue sections using Hyperion CyTOF.

Areas of Expertise:CSCAR staff have expertise in the areas of Biostatistical analyses; Formulation of research aims and development of plans for data collection and analysis; expertise in R, Python, SAS, SPSS, Stata, and Fortran. In addition, can advise clients on the use of number of other statistical and technical software packages.

Core provides services in Clinical Chemistry, Clinical Mass Spectrometry , Hematology, Body Fluids, Urinalysis, Quantitative Flow Cytometry, Coagulation, BioChemical Genetics.

Core facility primary mission is to provide access to advanced NMR spectroscopic methods and tools to students, postdoctoral fellows, and faculty of the University for the advancement of their research.

Facility provides specialized MS services. The major areas of focus of the lab are Analysis of intact proteins, multi-protein complexes, and protein structure; Identification and purification of compounds from complex mixtures coupled with quantitative analysis.; Purification using mass directed autopurification liquid chromatography. Users can be trained on the instruments for walk-up use or samples can be submitted for analysis.

Facility provides imaging instruments and imaging services for research community. Offers imaging systems including IVIS Spectrum bioluminescent/fluorescent imaging system, Bruker 7 Tesla horizontal bore MRI system, 4DMedical Permetium lung CT system, and Bruker SkyScan CT system.

Core provides training, education, statistics and data management services.
Services include: experimental design of new studies, advising on outcomes selection,
determining or justifying sample size, designing randomization schemes,designing and writing the statistical analysis/modeling section(s), advising on appropriate database design and implementation methods, advising on the use of national data registries, health system data, grant writing on relevant sections within our specialties, creating custom databases and data entry portals for prospective studies, creating custom datasets or extracts from existing data sources for analysis, merging complex or multi-sourced data in concert with research aims and objectives, implementing blind, double-blind and other randomization schemes and more.

Provides full-service consultation, sample processing and results. After running your samples, we will process your data using Mestranova and give you access to the raw data via email or Dropbox.

Services include Particle Characterization, Thermal Characterization, Materials Characterization. Core provides training and expertise. You must complete your Nanotechnicum Lab Safety Training has to be completed to use core equipment.

Vector Core produces gene transfer vectors that facilitate transfer of specific genes into either normal or aberrant cells. Provides intellectual and technical advice to researchers regarding the optimal use of these systems.

Core provides irradiation services for investigators, including those whose primary interests are not in radiation biology, but who need this tool in support of other efforts, such immunosuppression of animals prior to stem cell transplantation through total body irradiation. Facility is equipped to perform moderate dose rate gamma irradiation (0.1-4 Gy/min) of cell cultures, tissue specimens or animals as well as low dose rate irradiation (0.05-0.3 Gy/hr) of cell cultures.

Our services consist of research pathology support for non-GLP preclinical or basic science animal studies. Services include histology and immunohistochemistry, animal hematology and clinical chemistry, digital slide scanning/image analysis, and pathology interpretation by board-certified veterinary pathologists. We specialize in support of academic or early -phase (discovery) preclinical research. Our laboratory maintains internal SOPs and accountability/chain-of-custody records for all submissions. Additionally, we participate in an external quality control program (Veterinary Laboratory Association). Our core mission is to reduce bias and increase rigor of preclinical research in academia by providing high quality support services that may not be otherwise accessible within individual laboratories.

Library of >50,000 NPEs with technology and expertise to develop candidates identified through HTS into unique, bioactive, patentable small molecules.

HTS of extensive small molecule, natural products, and siRNA libraries for basic biology and drug discovery projects.

The University of Michigan Center for Structural Biology (CSB), is a comprehensive structural biology resource for researchers at the University of Michigan and surrounding areas.

The CSB includes a high-throughput protein laboratory for protein engineering, protein purification facilities for small- and large-scale protein production, macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules, and an X-ray facility with access to high energy synchrotron radiation. Our dedicated staff scientists have years of academic and industry experience, allowing us to provide expert guidance to researchers through every stage of a project — collaborating and consulting with researchers who use the facilities.

Service Categories: Chemical, Material and Protein Characterization, Molecular Biology

Services: Cloning, Crystallization, Differential thermal analysis, Drug development, NMR (small molecule), PCR, Protein crystallography, Protein engineering, Protein production, Structure determination, Xray

https://www.lsi.umich.edu/science/centers-technologies/center-structural-biology

Advances in microscope technology and computing have paved the way for cryo-electron microscopy to move structural biology into a new era — allowing scientists to study the form and function of biological "machines" that are too large to study using X-ray crystallography.

The U-M Life Sciences Institute is home to a world-class cryo-EM laboratory, with state-of-the-art instruments and faculty specializing in this emerging field.

The Statistics Online Computational Resource (SOCR) designs, validates and freely disseminates knowledge. Specifically, SOCR develops AI/ML tools, mathematical models, and end-to-end data analytic protocols for biomedical and health studies. It also provides portable online aids for probability, statistics and health science education, promotes technology-enhanced instruction, supports efficient statistical computing, and advances predictive big data analytics. The SOCR platform includes a repository of interactive apps, computational tools, visualization approaches, instructional resources, learning materials, and curricular components. SOCR faculty, staff, and students support data and information science collaborations and analytic partnerships involving biomedical, healthcare, and biostatistical investigations.

The University of Michigan Bioinformatics Core helps researchers identify and interpret patterns in RNA and DNA by placing sequencing data into a biologically meaningful context. This encompasses assisting with experimental design, developing reproducible workflows, analyzing next-generation sequencing data, and supporting manuscript development/publication.

The Epigenomics Core provides resources and services to prepare samples for analysis in epigenetic regulation in both genome-wide and locus-specific manners.

The Epigenomics Core provides sample quality control, library preparation and sequencing for the study of cytosine and histone modifications. We offer a wide variety of services in epigenomics and bioinformatics resources, including:
• Genome-wide DNA Methylation Profiling
• Targeted (locus-specific) DNA Methylation
• Histone Modifications by ChIP-Seq
• Hydroxymethylation: Genome-wide and Target Specific

The Proteomics & Peptide Synthesis Core provides access to research services in peptide synthesis, proteomics and protein analysis by mass spectrometry and other techniques:

• experimental design and data interpretation
• finding the best analysis/synthesis options for your project scope and budget
• access to a wide variety of high-quality services from routine to customized projects in qualitative or quantitative proteomics
• N-terminal sequencing and Amino Acid Analysis
• quality custom peptide synthesis at discounted prices

Our service commitment is based on quality, reliability and customer satisfaction.

The Flow Cytometry Core provides instrumentation and expertise to University of Michigan investigators - and the surrounding biotech community - in a broad range of basic and medical science disciplines. Samples are prepared by individual investigators, who then deliver samples to the Core for flow cytometric analysis or cell sorting. The Core also provides assistance in grant and publication preparation, publication-quality graphics, and development of experimental designs.

Core Services:
• Flow Cytometry analysis
• Cell sorting
• Experimental design
• Application development
• Data storage
• Grant application support
• Publication development
• Graphics presentations