Facility Details

The Genetically Engineered Murine Models (GEMM) Core provides full-service mouse genetic engineering support to researchers. We will help you select the best model for your research program, design and build any requisite constructs and reagents, and produce live mice. The most popular requests are for CRISPR-based gene edited mice and transgenic mice. To date, we have created engineered alleles for knockouts, conditional knockouts, SNP knockins, tag and marker insertions, deletions of up to 300kb, duplications, and transgenic alleles. These novel mouse models have been made on a wide spectrum of genetic background strains, including but not limited to C57BL/6J, C57BL/6N, NOD, BALB/cJ, FVB/Crl, NSGS, various 129 substrains, collaborative cross strains, and on mice that are already genetically modified.

Our robust breeding and genotyping program supports breeding to establish germline transmission and can also create cohorts for investigators. We also provide strain cryopreservation, rederivation and rescue services, as well as cryostorage. Our services are available to outside institutions, nationally and internationally.