AMDL is a clinical CAP/CLIA accredited molecular diagnostics laboratory at the Princess Margaret Cancer Centre. Supports clinical trials and translational research projects requiring clinical-grade (CAP/CLIA) molecular testing at Princess Margaret Cancer Centre. AMDL works closely with Molecular Diagnostics lab in Toronto General Hospital to transition protocols into clinical tests.

Core provides specialized, high-dimensional immune profiling for clinical and translational studies. It enables researchers to analyze immune responses using advanced flow cytometry, CyTOF, genomics, and cytokine analysis, helping to improve cancer treatments and patient outcomes.

NMR Core Facility is equipped with NMR spectrometers allowing researchers to Characterize bio-molecular structures at the atomic resolution with exquisite details;Identify protein interactions with binding partners in order to understand their architecture;Study protein dynamic;Study protein post-translational modifications acting as molecular switches;Study structure-function relationships of biological proteins to gain insight into biological processes in relation to human disease;Screening of High-throughput drug-like leads for novel therapeutic targets;Study Metabolites of interest.Core facility houses high-field NMR spectrometers equipped with cryogenically cooled probes (1H or 13C optimized) for enhanced sensitivity.

Core provides biospecimen processing and performs automated slide-based biomarker methods (protein/RNA/DNA), implementing good clinical laboratory practices.Offers specialized consultation and perform biomarker development and analyses within clinical study and research program protocols.Provides services to the clinical trials and pre-clinical research community and expertise in biomarker selection, method development, optimization and standardization, and provision of quality consultation on biomarkers for clinical research protocols.

Core offers services in Analytical Flow Cytometry, Fluorescence Activated Cell Sorting, consultation and data analysis. Staff provides training, assisted acquisition, consultation, and data analysis upon request.

Core provides services including Basic High-Throughput Sequencing Analysis, Advanced Data Analysis, High Performance Computing.

Offers services to support studies in medical fields across oncology, cardiology, metabolic diseases, radiotheranostics and more.Helps with study design to final data analysis, including GLP-compliant histopathology services.

Core provides services for the use of patient-Derived tumor Organoid (PDO) model.Organoid models are derived from patient-derived xenograft tissues, primary tumors, and metastatic patient tissues. PMLB organoid repository includes models generated from colorectal, pancreatic, and lung cancer tissues.

Core offers cell sorting and flow cytometry services. Provided instruments include BD FACS Canto II, Beckman Cytoflex LX, BD FACS ARIA III, AutoMacs Cell Separator.

Core offers services including Study planning and design; Grant writing and protocol creation; Data collection form design; Data capture instrument construction; Complex data processing and linkage; Quality control involvement; Statistical analysis, figure, and table generation; Manuscript drafting and presentation preparation; Response to manuscript reviews from regulatory agencies and journals.

Provides testing and analysis support for clinical trials to improve consistency and reliability in clinical trial data.Helps clinical investigators achieve systematic image collection and improved collaboration. Can help with handling large volume functional and dynamic imaging data.

Facility provides analytical flow cytometers and high-speed cell sorting, as well as training, education and consultation services.

Core is dedicated to providing access to cost-effective and high quality genomics services including standard and custom-tailored DNA sequencing using Illumina technologies, epigenomics, panel-based profiling (Luminex and Nanostring) and functional genomics. Single cell genomics applications on variety of popular platforms.

Core provides services for the use of Xenograft (PDX) models listed in open global catalogue of PDX models for comprehensive search and attribute filtering support for clinico-pathological and molecular data. Molecular data and visualization of profiled models could be accessed through the institute's portal.

Core offers biobanking services and diverse inventory of biospecimens in the field of Oncology. Offers prospective protocol specific banking tailored to your research needs, including patient eligibility, screening, consenting, biospecimen procurement, handling, and processing, clinical data annotation, short and long-term sample storage, and shipping.

Core supports biomarker discovery and enhancing future cancer research in the areas of genomics, proteomics and epidemiology. Provides serialized collections of biospeciments throughout patient prognosis. Clinical time point collections are based on input from our expert surgical, medical, and radiation oncologist teams.

Core services include Imaging Modalities:MRI,PET-MRI,CT,PET-CT,Ultrasound / X-Ray,Interventional / Biopsies;Consultation:Pre-grant submission consultations,Pre-trial launch consultations / site initiation visists,Feasibility assessments MRI physics consultation; Protocol Development / Site Feasibility:Industry site feasibility questionnaires, Protocol development of medical imaging studies and clinical trials; Post-Processing of Images:Tumour measurements, Volumetric measurements.

Core provide services for the enhancement and progression of novel and innovative research and discovery. Provides human biospecimen samples such as: fresh frozen and formalin fixed paraffin embedded (FFPE) tissue, compartmentalized blood components such as serum, plasma, and whole blood peripheral blood mononuclear cells (PBMCs) and other biofluids, including saliva and urine; Tissue microarray (TMA) construction and quantitative image analysis of TMA sections, Laser capture microdissection (LCM), digital slide scanning, quantitative image, and pathological/clinical analysis for various tumour sites and DNA/RNA extraction; support and guidance to researchers and biobanks on accessing, collecting, and using human biospecimens and associated data for health research.

The Advanced Optical Microscopy Facility (AOMF) is centrally located in the Discovery District in Toronto, Ontario, serving University Health Network as well as external academic and industrial users. It is the largest microscopy facility in Canada with instruments at Princess Margaret Hospital and Toronto General Hospital. With over 30 instruments and 4 staff members, the AOMF is equipped to help you with nearly any optical microscopy application including: confocal, multiphoton, FRAP, FRET, live-cell, timelapse, spectral unmixing, in-vivo bioluminescence and fluorescence, whole-slide scanning, 3D rendering, colocalization and more.

We offer:
- Free consultations to determine which microscopes would best suit your application
- Comprehensive training and support on our various instruments
- Full-service image capture and analysis (a great way to get started quickly)
- High-resolution whole slide scanning service for histology slides
- Practical courses on microscopy, including one-on-one hands-on sessions (eg: Fundamentals of Microscopy) and larger workshops tailored to your group's applications
- Software and training for image processing and quantification