Core provides irradiation services for investigators, including those whose primary interests are not in radiation biology, but who need this tool in support of other efforts, such immunosuppression of animals prior to stem cell transplantation through total body irradiation. Facility is equipped to perform moderate dose rate gamma irradiation (0.1-4 Gy/min) of cell cultures, tissue specimens or animals as well as low dose rate irradiation (0.05-0.3 Gy/hr) of cell cultures.

Our services consist of research pathology support for non-GLP preclinical or basic science animal studies. Services include histology and immunohistochemistry, animal hematology and clinical chemistry, digital slide scanning/image analysis, and pathology interpretation by board-certified veterinary pathologists. We specialize in support of academic or early -phase (discovery) preclinical research. Our laboratory maintains internal SOPs and accountability/chain-of-custody records for all submissions. Additionally, we participate in an external quality control program (Veterinary Laboratory Association). Our core mission is to reduce bias and increase rigor of preclinical research in academia by providing high quality support services that may not be otherwise accessible within individual laboratories.

Library of >50,000 NPEs with technology and expertise to develop candidates identified through HTS into unique, bioactive, patentable small molecules.

HTS of extensive small molecule, natural products, and siRNA libraries for basic biology and drug discovery projects.

The University of Michigan Center for Structural Biology (CSB), is a comprehensive structural biology resource for researchers at the University of Michigan and surrounding areas.

The CSB includes a high-throughput protein laboratory for protein engineering, protein purification facilities for small- and large-scale protein production, macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules, and an X-ray facility with access to high energy synchrotron radiation. Our dedicated staff scientists have years of academic and industry experience, allowing us to provide expert guidance to researchers through every stage of a project — collaborating and consulting with researchers who use the facilities.

Service Categories: Chemical, Material and Protein Characterization, Molecular Biology

Services: Cloning, Crystallization, Differential thermal analysis, Drug development, NMR (small molecule), PCR, Protein crystallography, Protein engineering, Protein production, Structure determination, Xray

https://www.lsi.umich.edu/science/centers-technologies/center-structural-biology

Advances in microscope technology and computing have paved the way for cryo-electron microscopy to move structural biology into a new era — allowing scientists to study the form and function of biological "machines" that are too large to study using X-ray crystallography.

The U-M Life Sciences Institute is home to a world-class cryo-EM laboratory, with state-of-the-art instruments and faculty specializing in this emerging field.

The Statistics Online Computational Resource (SOCR) designs, validates and freely disseminates knowledge. Specifically, SOCR develops AI/ML tools, mathematical models, and end-to-end data analytic protocols for biomedical and health studies. It also provides portable online aids for probability, statistics and health science education, promotes technology-enhanced instruction, supports efficient statistical computing, and advances predictive big data analytics. The SOCR platform includes a repository of interactive apps, computational tools, visualization approaches, instructional resources, learning materials, and curricular components. SOCR faculty, staff, and students support data and information science collaborations and analytic partnerships involving biomedical, healthcare, and biostatistical investigations.

The University of Michigan Bioinformatics Core helps researchers identify and interpret patterns in RNA and DNA by placing sequencing data into a biologically meaningful context. This encompasses assisting with experimental design, developing reproducible workflows, analyzing next-generation sequencing data, and supporting manuscript development/publication.

The Epigenomics Core provides resources and services to prepare samples for analysis in epigenetic regulation in both genome-wide and locus-specific manners.

The Epigenomics Core provides sample quality control, library preparation and sequencing for the study of cytosine and histone modifications. We offer a wide variety of services in epigenomics and bioinformatics resources, including:
• Genome-wide DNA Methylation Profiling
• Targeted (locus-specific) DNA Methylation
• Histone Modifications by ChIP-Seq
• Hydroxymethylation: Genome-wide and Target Specific

The Proteomics & Peptide Synthesis Core provides access to research services in peptide synthesis, proteomics and protein analysis by mass spectrometry and other techniques:

• experimental design and data interpretation
• finding the best analysis/synthesis options for your project scope and budget
• access to a wide variety of high-quality services from routine to customized projects in qualitative or quantitative proteomics
• N-terminal sequencing and Amino Acid Analysis
• quality custom peptide synthesis at discounted prices

Our service commitment is based on quality, reliability and customer satisfaction.

The Flow Cytometry Core provides instrumentation and expertise to University of Michigan investigators - and the surrounding biotech community - in a broad range of basic and medical science disciplines. Samples are prepared by individual investigators, who then deliver samples to the Core for flow cytometric analysis or cell sorting. The Core also provides assistance in grant and publication preparation, publication-quality graphics, and development of experimental designs.

Core Services:
• Flow Cytometry analysis
• Cell sorting
• Experimental design
• Application development
• Data storage
• Grant application support
• Publication development
• Graphics presentations