The Genomics Core hopes to provide a centralized resource working to take the difficulty out of Next Generation Sequencing projects for both novice and experienced users alike. To accomplish this we provide assistance in all facets of experimentation from design to data analysis including grant and manuscript preparations. We are a facility that offers NGS, Sanger, Informatics and Genotyping services based off of the Illumina platform.

The Case Center for Imaging Research (CCIR) exists to help further the study of imaging. Within the CCIR, the Imaging Research Core provides a comprehensive suite of preclinical and clinical imaging instrumentation and techniques developed in-house by our leading imaging scientists.

The Core services the CWRU and University Hospitals research communities, researchers and industry partners throughout University Circle and Northeast Ohio, and across the country.

The Imaging Research Core offers the expertise, infrastructure, and environment that can help turn your research into a reality.

Core offers quality controlled media at economical prices. Media is prepared in large batches ranging from 50L-300L from commercially produced powders. All products go through strict quality control program. Custom plates and media are offered by request and are usually available within 2-4 business days. All other orders placed online can be picked up on the next business day.

Core provides monoclonal antibody production services. Provides consultation to assist investigator in all aspects of monoclonal antibody production. Services are performed under strict quality control guidelines appropriate for antibodies that may have commercial potential.

Core provides glassware washing and sterilization of all types of glassware and pipettes. Facility maintains stock glassware in common storage area. Glassware personnel collect glassware from laboratories daily and cabinets are replenished regularly. Autoclaving of materials is offered on daily basis. Core can accommodate any special requests. Glassware Core maintains stock of all types of sterile laboratory glassware and pipettes in common storage area.

Core provides specialized cell culture services , ensures high-quality and contamination-free cultures by employing aseptic techniques and maintaining Mycoplasma and Quarantine facilities. Offers cell banking, with capacity to freeze and store up to 10,000 vials. Facility provides walk-in warm room and cold room, spinner apparatus capable of handling over 20 liters of cells in suspension, and roller bottle machine that accommodates more than 200 roller bottles. Additional equipment includes automated cell counter and ELISA reader.

Core provides services, from DNA and RNA extraction from diverse sample types such as tissue, stool, and bacterial isolates to next-generation sequencing, including whole-genome sequencing, total RNA-seq, metatranscriptomics, and dual RNA-seq, along with expert bioinformatics support. Core expertise spans 16S rRNA amplicon sequencing, shotgun metagenomics, metatranscriptomics, meta-omics analysis of dual RNA-seq, and single-cell RNA-seq data. Core also assists with experimental design and power calculations to ensure statistically robust results, offering consultation at every stage, from experimental design to data interpretation and troubleshooting.

Core provides advanced mass-spectrometric instrumentation and for both proteomics and metabolomic experiments. Performs qualitative and quantitative analysis of proteins and post-translationally modified peptides and both targeted and untargeted LC/GC-MS based metabolomics.

The Imaging Core at CCF FRIC provides access to advanced imaging technologies, including:

Wide-field and confocal fluorescent microscopes
FLIM capability
Live-cell imaging microscopes
Pre-clinical imaging microscopes
BSL-3 imaging platforms for pre-clinical and basic research microscopy projects


The core also offers support for researchers and their projects beyond hardware. Our expert staff can provide consultation on experimental design and optimization, post-acquisition image processing, and support for analysis, visualization, and interpretation of data. The analysis workstation in the facility runs a full suite of analysis and visualization software packages for getting the most rigorous quantification and representation of your imaging data.