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All Facilities >> University of California, Santa Cruz >> UCSC-Macromolecular Structure Function Core Facility (Structural Biology)
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Sarvind Tripathi
Last Updated: 06/01/2021
The Macromolecular Structure Function Core Facility (MSFCF) supports Biochemistry and Structural Biology researchers at UC Santa Cruz and the surrounding area. We provide state of the art instrumentation, supplies, and expertise to assist researchers in the structural characterization of biological macromolecules. Resources are available for crystallization and structure determination as wells as biophysical characterization of macromolecular stability and interactions.
Services are offerred outside of University of California, Santa Cruz
Consulting is offerred outside of University of California, Santa Cruz
Art Robbins Crystal Gryphon Liquid Crystal Polymer Setup System
Gryphon LCP is a setup system for Lipidic Cubic Phase sandwich plates and bicelle assays as well as traditional protein crystallography plates. A dedicated syringe based LCP head dispenses the protein, and a 96 head dispenses the buffer solutions. A 96 well sandwich plate can be sealed in less than 2 minutes. An optional non-contact dispenser can be added at any time to set up vapor diffusion sitting drop and hanging drop plates. The Crystal Gryphon is a small, fast and option for setting up all of your crystal plates. The Crystal Gryphon fits into tight lab spaces and tight lab budgets. The 96-channel positive displacement head quickly fills screen reservoirs and protein wells. The head has no disposable tips, so the cost of operation and environmental waste is minimized. The 1-channel non-contact dispenser quickly aspirates and dispenses your proteins allowing your plate to be sealed without evaporation being a problem. This dispense head is designed specifically to handle proteins, features flow-through washing and positive displacement aspiration, to handle all of your proteins. [Product Link]
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General Electric AKTA FPLC System, Protein Purification System
Purification system intended for microgram-scale protein purifications in Tricorn columns up to milligram-scale using HiTrap and HiScreen columns. For fast protein liquid chromatography of tens of grams of protein,can be used with flow rates up to 150 mL/min. This high flow rate is necessary when working with high-flow resins in large columns. Columns can even be packed at flow rates as high as 300 mL/min. System reduces hands-on time so that you can spend less time purifying proteins and more time focusing on your results. Easily switch between different users and applications. To get you up and running quickly, methods are easily created by dragging and dropping predefined templates in UNICORN 7. Purification of protein to sufficiently high yield and purity can be a time- and resource-consuming process. To address fast and efficient protein purification, Can be set up in different ways to handle multistep purification. With an additional column valve up to 10 columns can be connected enabling automation of several samples and steps. [Product Link]
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Microcal VPViewerTM Differential Scanning Calorimeter VP--DSC
Differential scanning calorimeter for study of samples in solution. It measures intramolecular stability of proteins, nucleic acids, oligomeric proteins, nucleic acid duplexes, lipid and detergent micellar system. [Product Link]
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https://coremarketplace.org/?FacilityID=1184Institution
Institution ROR ID: https://ror.org/03s65by71Keywords:
USEDit, ABRF
Resource Type:
service resource, core facility, access service resource
Citation:
University of California Santa Cruz Macromolecular Structure Function Core Facility (RRID:SCR_021283)
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