Core provides preclinical imaging and radiation treatment resources for animal research.

Core provides services for researchers in need of behavioral analyses in small animals (specifically mice or rats). Core provides expertise in design and implementation of behavioral experiments as well as data analysis and interpretation. Core is equipped to accommodate behavioral tests relevant to learning and memory, attention, executive function, sensory gating, place/fear conditioning, motor function, nociception, and anxiety and depression-related behaviors etc. Testing facility is operated within centralized animal care program of Division of Laboratory Animal Services.

Core offers variety of specimen preparation services for transmission and scanning electron microscopy, vibratome, paraffin, cryostat and JB-4 sectioning.Offers routine staining and various histological special stains, PASH, Masson Trichrome, Van Gieson and many others, immunohistochemical services including immuno-EM studies. Core staff performs all aspects of the ultrastructural procedures from specimen processing to imaging (for Electron Microscopy, TEM and SEM) and processing, sectioning, and staining for light microscopy (paraffin, cryostat, and JB-4).

Core provides imaging and expert technical assistance and instrumentation in support of investigators.

Core provides services in Assay Development, Assays Experimental Design, Immune Monitoring, Cytokine Assays, ELISA, multiplex Flow based and Luminex based Bead Arrays, Project Based Flow Cytometry and Data Analysis.

Core offers services from sample processing from both fresh and frozen, as well as fixed cells or tissues to library preparation and next-generation sequencing (NGS) for bulk DNA/RNA sequencing and single-cell/nuclei sequencing. For single-cell studies, core is equipped with Chromium X system from 10X Genomics. Sequencing capabilities include Illumina Novaseq6000 and NextSeq 500. Offers single cell spatial transcriptomics with CosMx SMI platform. Other equipped includes CytAssit instrument from 10X genomics for VISIUM spatial transcriptomic and QIAConnect from Qiagen for nucleic acid and protein extraction.

Core offers services including assay development, FDA-drug library screening, unbiased compound screening, high-content imaging and screening. Facility can empower researchers to repurpose existing FDA-approved drugs and discover new compounds for drug development. Provides affordable platform for discovering therapeutic targets and interventions, supporting drug development from target identification to screening and validation. Features HTS facilities, including Biomek i7 Liquid Handling system, Pherastar FSX plate reader, ImageXpress Micro Confocal, and Pala cell sorter.