is_active:

Yes

budget_end:

04/30/2025

date_added:

05/04/2024

agency_code:

NIH

fiscal_year:

2024

project_num:

5P51OD011132-64

award_amount:

$10,751,414.00

budget_start:

05/01/2024

org_name:

EMORY UNIVERSITY

org_state:

GA

org_country:

UNITED STATES

org_zipcode:

303221007

primary_duns:

066469933

abstract_text:

OVERALL – SUMMARY/ABSTRACT This application seeks five years of continued support for the P51 Base Grant (OD 011132) for the operation of the Yerkes National Primate Research Center of Emory University. The overarching goals of the Yerkes Center are to conduct research programs focused on scientific problems relevant to human health and the NIH mission by providing resource infrastructure and expertise in appropriate scientific and veterinary specialties and to ensure the Center’s ability to serve as a resource to Core and Affiliated Scientists, as well as to other scientists regionally, nationally and internationally. During the current reporting period (5/1/2016 to present), the Yerkes Center has recorded remarkable progress, as evidenced by numerous (>550) publications, construction of new animal facilities, and continued robust research funding. In addition, the Yerkes Primate Center has maintained outstanding core research programs and provided resources and services to a broad multidisciplinary network of affiliate and collaborative investigators throughout the region and nation. These research programs, which involve the use of a variety of nonhuman primate species, are directed primarily toward four major research disciplines, representing the research divisions within the Yerkes Center: 1) Microbiology and Immunology; 2) Developmental and Cognitive Neuroscience, 3) Neuropharmacology and Neurologic Diseases and 4) Behavioral Neuroscience and Psychiatric Disorders. Also, through the Divisions of Animal Resources and Pathology, Yerkes provides support for outside investigators conducting research at the Yerkes Center, consistent with our ORIP-mandated role as a regional and national resource. Specific aims for the upcoming period of support include: 1) To carry out basic and translational research using nonhuman primates to expand knowledge, develop improved treatments, and advance cures that will benefit humanity; 2) To provide regional and national resources for data, consultative expertise, biologic materials, and specialized facilities useful in supporting nonhuman primate research; 3) To study basic nonhuman primate biology and improve nonhuman primate breeding, husbandry, and genetic characterization to better serve the biomedical research community; and 4) To provide research and training opportunities involving nonhuman primates to graduate and undergraduate students, postdoctoral fellows, visiting scientists, and faculty members. The pursuit of these aims will enhance the Center’s ability to serve as an enabling resource to Core and Affiliate Scientists for the conduct of nonhuman primate research, all for the ultimate goal of advancing the health and well-being of human and nonhuman primates.

project_title:

Emory National Primate Research Center

contact_pi_name:

THADHANI, RAVI

total_cost:

$10,751,414.00

is_active:

No

budget_end:

08/01/2020

date_added:

08/03/2019

agency_code:

NIH

fiscal_year:

2019

project_num:

1S10OD026799-01

award_amount:

$985,030.00

budget_start:

08/02/2019

org_name:

EMORY UNIVERSITY

org_state:

GA

org_country:

UNITED STATES

org_zipcode:

303221007

primary_duns:

066469933

abstract_text:

PROJECT SUMMARY/ABSTRACT: The Yerkes National Primate Research Center Genomics Core is requesting support to acquire an Illumina NovaSeq 6000 sequencing system. Since 2011, the Genomics Core has served a diverse collection of Yerkes and Emory University investigators; assisted in planning, preparing, and executing many projects having dynamic deep-sequencing needs. From the characterization of genome-wide DNA methylation profiles in the context of neurodegeneration, to identifying differentially expressed genes following various vaccination regimens, the Genomics Core has worked closely with investigators to successfully meet the demands of their research programs. Over the past several years, massively parallel deep sequencing has made significant contributions to biomedical research– particularly due to increased affordability and practicality over more conventional approaches to gene sequence and expression characterization. Our growing user base, and the increased sophistication of our users’ needs, requires the Genomics Core to replace our existing Illumina HiSeq 3000 with the NovaSeq 6000, which will decrease turn-around time, decrease sequencing costs, and increase the volume of samples that can be sequenced simultaneously. The NovaSeq 6000 will bring genome-center capabilities to the Yerkes Genomics Core– investigators will have in-house access to genome-scale deep sequencing services with corresponding informatics support. Our users, minor and major, correspond to investigators leading their field, and supporting their evolving sequencing needs by acquiring an Illumina NovaSeq 6000 will undoubtedly benefit the larger scientific community.

project_title:

Illumina NovaSeq 6000 High Throughput DNA Sequencer for Emory University

contact_pi_name:

BOSINGER, STEVEN EDWARD

total_cost:

$985,030.00