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Texas A&M University
Department of Chemistry
College Station, TX 77843United Stateshttps://lsbi.chem.tamu.edu/
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Last Updated: 05/10/2022
The Laboratory for Synthetic-Biologic Interactions (LSBI) is a research facility housed in the Department of Chemistry. The LSBI is designed to be a multi-user laboratory supporting major research initiatives within the Chemistry Department, the university and extending to the broader academic and industrial scientific communities. Fifteen instruments are currently available on a fee-for-use basis, and others may be made available on case-by-case considerations.
Services are offerred outside of Texas A&M University
Consulting is offerred outside of Texas A&M University
Horiba FluoroMax 4 Spectrofluorometer
FluoroMax family, with its all reflective optics and photon counting was the first to bring the sensitivity of a modular fluorometer to a tabletop fluorescence instrument. It's a compact spectrofluorometer, yet offers the ultimate sensitivity in fluorescence investigations as well as features not found in most table-top fluorescence detection systems. The FluoroMax series consists of the FluoroMax-4, the latest generation of the original, high performance tabletop fluorometer, which offers extended performance with detection of emission spectra out to 1700 nm and (TCSPC) Time Correlated Single Photon Counting lifetime measurements as short as 25ps. [Product Link]
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Molecular Devices SpectraMax M5 Multimode Plate Reader
Microplate Reader delivers single mode reader performance and can be equipped to read volumes as low as 2uL in one multimode reader package. The dual monochromator optics allow the widest range of applications to be utilized for bioresearch and drug discovery applications, all without the need to change filters. For fluorescence intensity, time resolved fluorescence, and fluorescence polarization assays, the SpectraMax M5 Microplate Reader optical design provides the highest level of flexibility. Users can select from top or bottom read modes for improved sensitivity for solution and cell-based assays. Assays can be better optimized by scanning across a range of wavelengths in increments as small as 1 nm. Up to 4 wavelength pairs can be read in one protocol for endpoint and kinetic measurements, allowing for fast setup of FRET and TR-FRET assays. For luminescence, the SpectraMax M5 Microplate Reader utilizes a dedicated luminescence photomultiplier tube (PMT), providing the user the maximum signal and lowest background possible for glow luminescence reporter gene assays. The SpectraMax M5 utilizes a single monochromator design for UV/VIS Absorbance, allowing the user to maximize sensitivity and tunability, and also uses patented PathCheck Pathlength Measurement Technology: the only temperature independent pathlength correction for microplates. The M5 can read volumes down to 2uL with the uMax Low Volume Plate. [Product Link]
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Olympus FV1000 Confocal Microscope
Next generation imaging system designed for high resolution, confocal observation of both fixed and living cells.FV1000 offers advances in confocal system performance while providing the speed and sensitivity required for live cell imaging with minimal risk of damage to living specimens.In addition, the FV1000 offers a revolutionary synchronized laser scanning system called the SIM Scanner. While one laser stimulates, the second laser simultaneously provides high-resolution imaging. This coordination of laser stimulation and imaging makes the FV1000 an ideal choice for FRAP, FLIP and photoactivation. [Product Link]
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Olympus IX70 Inverted Fluorescence Tissue Culture Microscope
Inverted fluorescence tissue culture microscope capable of imaging specimens in brightfield, darkfield, phase contrast, hoffman modulation contrast, fluorescence, and differential interference contrast modes. [Product Link]
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Shimadzu IR Prestige 21 FTIR
Shimadzu AIM 8800 FTIR Microscope
Biolin Attension Tensiometer
Mettler Toledo DMA 1
ATS Rheosystems Black Pearl Viscometer
Biolin Q-Sense QCM-D
B&W Tek i-Raman
PicoQuant FluoTime 100 TCSPC
Zetasizer Nano ZS DLS
Bruker Xtreme 4MP
Publications associated with this facility (Click To View):
1.) Elsabahy M, Song Y, Eissa NG, Khan S, Hamad MA, Wooley KL (2021 Jun 10). Morphologic design of sugar-based polymer nanoparticles for delivery of antidiabetic peptides. Journal of controlled release : official journal of the Controlled Release Society, 334(), 1-10. . ID: 33845056.
2.) Nguyen TP, Easley AD, Kang N, Khan S, Lim SM, Rezenom YH, Wang S, Tran DK, Fan J, Letteri RA, He X, Su L, Yu CH, Lutkenhaus JL, Wooley KL (2021 May). Polypeptide organic radical batteries. Nature, 593(7857), 61-66. doi: 10.1038/s41586-021-03399-1. ID: 33953410.
3.) Jeevarathinam AS, Guo F, Williams T, Smolen JA, Hyde JA, McShane MJ, de Figueiredo P, Alge DL (2021 Jan). Enzyme functionalized microgels enable precise regulation of dissolved oxygen and anaerobe culture. Materials today. Bio, 9(), 100092. doi: 10.1016/j.mtbio.2020.100092. ID: 33554105.
4.) Song Y, Yang X, Shen Y, Dong M, Lin YN, Hall MB, Wooley KL (2020 Oct 7). Invoking Side-Chain Functionality for the Mediation of Regioselectivity during Ring-Opening Polymerization of Glucose Carbonates. Journal of the American Chemical Society, 142(40), 16974-16981. doi: 10.1021/jacs.0c05610. ID: 32965109.
5.) Lin YN, Khan S, Song Y, Dong M, Shen Y, Tran DK, Pang C, Zhang F, Wooley KL (2020 Sep 9). A Tale of Drug-Carrier Optimization: Controlling Stimuli Sensitivity via Nanoparticle Hydrophobicity through Drug Loading. Nano letters, 20(9), 6563-6571. doi: 10.1021/acs.nanolett.0c02319. ID: 32787153.
6.) Li R, Wang H, Song Y, Lin YN, Dong M, Shen Y, Khan S, Zhang S, Fan J, Zhang F, Su L, Wooley KL (2019 Dec 18). <i>In Situ</i> Production of Ag/Polymer Asymmetric Nanoparticles via a Powerful Light-Driven Technique. Journal of the American Chemical Society, 141(50), 19542-19545. doi: 10.1021/jacs.9b10205. ID: 31820965.
7.) Heo GS, Zhao Y, Sultan D, Zhang X, Detering L, Luehmann HP, Zhang X, Li R, Choksi A, Sharp S, Levingston S, Primeau T, Reichert DE, Sun G, Razani B, Li S, Weilbaecher KN, Dehdashti F, Wooley KL, Liu Y (2019 Jun 5). Assessment of Copper Nanoclusters for Accurate in Vivo Tumor Imaging and Potential for Translation. ACS applied materials & interfaces, 11(22), 19669-19678. doi: 10.1021/acsami.8b22752. ID: 31074257.
8.) Dong M, Wessels MG, Lee JY, Su L, Wang H, Letteri RA, Song Y, Lin YN, Chen Y, Li R, Pochan DJ, Jayaraman A, Wooley KL (2019 May 28). Experiments and Simulations of Complex Sugar-Based Coil-Brush Block Polymer Nanoassemblies in Aqueous Solution. ACS nano, 13(5), 5147-5162. doi: 10.1021/acsnano.8b08811. ID: 30990651.
9.) Leonhardt EE, Kang N, Hamad MA, Wooley KL, Elsabahy M (2019 May 24). Absorbable hemostatic hydrogels comprising composites of sacrificial templates and honeycomb-like nanofibrous mats of chitosan. Nature communications, 10(1), 2307. doi: 10.1038/s41467-019-10290-1. ID: 31127114.
10.) Elsabahy M, Wooley KL, Hendricksen A, Oh K (2019 Apr 1). Multiplexing techniques for measurement of the immunomodulatory effects of particulate materials: Precautions when testing micro- and nano-particles. Methods (San Diego, Calif.), 158(), 81-85. . ID: 30660862.
11.) Li R, Elsabahy M, Song Y, Wang H, Su L, Letteri RA, Khan S, Heo GS, Sun G, Liu Y, Wooley KL (2019 Feb 5). Functional, Degradable Zwitterionic Polyphosphoesters as Biocompatible Coating Materials for Metal Nanostructures. Langmuir : the ACS journal of surfaces and colloids, 35(5), 1503-1512. doi: 10.1021/acs.langmuir.8b02033. ID: 30346776.
12.) Wacker KT, Weems AC, Lim SM, Khan S, Felder SE, Dove AP, Wooley KL (2019 Jan 14). Harnessing the Chemical Diversity of the Natural Product Magnolol for the Synthesis of Renewable, Degradable Neolignan Thermosets with Tunable Thermomechanical Characteristics and Antioxidant Activity. Biomacromolecules, 20(1), 109-117. doi: 10.1021/acs.biomac.8b00771. ID: 30179461.
13.) Song Y, Ji X, Dong M, Li R, Lin YN, Wang H, Wooley KL (2018 Nov 28). Advancing the Development of Highly-Functionalizable Glucose-Based Polycarbonates by Tuning of the Glass Transition Temperature. Journal of the American Chemical Society, 140(47), 16053-16057. doi: 10.1021/jacs.8b10675. ID: 30418768.
14.) Zhang F, Khan S, Li R, Smolen JA, Zhang S, Zhu G, Su L, Jahnke AA, Elsabahy M, Chen X, Wooley KL (2017 Oct 26). Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading. Nanoscale, 9(41), 15773-15777. doi: 10.1039/c7nr05935c. ID: 29034932.
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Texas A and M University Laboratory for Synthetic Biologic Interactions Core Facility (RRID:SCR_022287)
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