Facility Details

The Protein Production, Characterization and Molecular Interaction (PPCMI) core provides cloning, expression and purification services of functional proteins at a scale that meets the quantity and purity benchmarks for structural, biophysical, biochemical, and therapeutics studies; it also characterizes macromolecular biophysics and interaction energetics using a wide variety of state-of-the-art instrumentation and techniques that can analyze association and kinetic binding constants by surface plasmon resonance, enthalpies and entropies of binding by isothermal titration calorimetry, as well as determination of stoichiometry, stability, and homogeneity by both techniques.