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All Facilities >> Texas A&M Health Science Center >> TAMU - Combinatorial Drug Discovery Program (CDDP)
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Texas A&M Health Science Center
2121 W. Holcombe Blvd
Texas A&M Institute of Biosciences and Technology
Houston, TX 77030
United Stateshttps://vpr.tamu.edu/core_facility/high-throughput-research-and-screening-center/Clifford Stephan
Last Updated: 04/27/2022
The Combinatorial Drug Discovery Program (CDDP) resides in the Texas A&M Health Science Center’s Institute of Biosciences and Technology, Houston, TX. This core provides industry standard high throughput screening and automated microscopy capabilities to scientists performing drug discovery research. The core provides many benefits, such as access to an automated infrastructure that is capable of supporting both both phenotypic and biochemical targets. The CDDP provides ready access to collections of current FDA-approved drugs and clinical candidates exhibiting the ‘drug-like’ qualities of acceptable solubility, desirable ADME/toxicology properties and adequate bioavailability. These properties are important for rapid advancement of new agents into successful preclinical and clinical trials by discovering new therapeutic vulnerabilities alone or in combinations. The CDDP also has collections of mechanistically annotated informer sets that are pathway specific modulators for studying mechanism of action or target identification. The core also has collections of natural products and diverse sets of small molecules that can be interrogated for new target discovery. The greatest benefit of the core; however, is its fulltime professional staff. The screening team is composed of highly experienced biologists, biochemists, pharmacologists and data scientists with both pharmaceutical industry and academic experience. Each project is individually evaluated and a team of scientists from the CDDP is created to fit the specific needs of the project from assay design and development through primary, secondary and orthogonal screening. The team is committed to providing an integrated and highly collaborative program with every investigator.
Services are offerred outside of Texas A&M Health Science Center
Consulting is offerred outside of Texas A&M Health Science Center
Computational - Bioinformatics
Computer-assisted Neuron Tracing And Analysis
Confocal Microscope With FCS/FLIM Capabilities
Data Analysis And Interpretation
Data Processing And Interpretation
Beckman Coulter Biomek FX Liquid Handler
Beckman Coulter Biomek NXp Robotic Liquid Handler is and uatomated liquid handler designed to handle every aspect of liquid handling, pipetting, dilution, dispensing and integration in to one compact unit that will let you add laboratory automation where you need it. This efficient robotic liquid handler is set with a Span-8 pipette model, 4 fixed tip heads and 4 disposables, with rotating gripper and 8 channel liquid level sensing for an efficient and hands-free workflow. This automated workstation has up to 12 deck positions, automated labware positioners, and labware stacking for on deck storage. The open-ended flexibility of this robotic handler helps keep your lab agile and adaptable to your needs. The Beckman Coulter Biomek NXp Automated Workstation has a dispensing volume of between 0.5 ?L - 5,000 ?L and supports labware from tubes to 1,536-well microplates with accurate intra-well pipetting. The Biomek NXP can integrate with third party devices, and is configurable to meet specific applications needs. This automated workstation is computer controlled through the Biomek software, a robust suite that compliments this efficient instrument with methods and capabilities for genomic, drug discovery & basic research workflows. The Biomek software guides users through set up and protocols, quickly and easily through an icon based interface, with data tracking and LIMS connectivity. [Product Link]
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BioMek NXp NXp
Beckman Coulter Biomek NXp Robotic Liquid Handler is designed to handle every aspect of liquid handling, pipetting, dilution, dispensing and integration in to one compact unit that will let you add laboratory automation where you need it. This efficient robotic liquid handler is set with a Span-8 pipette model, 4 fixed tip heads and 4 disposables, with rotating gripper and 8 channel liquid level sensing for an efficient and hands-free workflow. This automated workstation has up to 12 deck positions, automated labware positioners, and labware stacking for on deck storage. The open-ended flexibility of this robotic handler helps keep your lab agile and adaptable to your needs. The Beckman Coulter Biomek NXp Automated Workstation has a dispensing volume of between 0.5 ?L - 5,000 ?L and supports labware from tubes to 1,536-well microplates with accurate intra-well pipetting. The Biomek NXP can integrate with third party devices, and is configurable to meet specific applications needs. This automated workstation is computer controlled through the Biomek software, a robust suite that compliments this efficient instrument with methods and capabilities for genomic, drug discovery & basic research workflows. The Biomek software guides users through set up and protocols, quickly and easily through an icon based interface, with data tracking and LIMS connectivity. [Product Link]
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Molecular Devices ImageXpress High Content Confocal Imaging System
ImageXpress Micro Confocal system is a high-content solution that can switch between widefield and confocal imaging of fixed and live cells. It can capture high quality images of whole organisms, thick tissues, 2D and 3D models, and cellular or intracellular events. The spinning disc confocal and sCMOS camera enable imaging of fast and rare events like cardiac cell beating and stem cell differentiation. With MetaXpress software and flexible options like water immersion objectives to choose from, the system enables many confocal imaging applications from 3D assay development to screening. [Product Link]
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Labcyte Echo 550
Labcyte Access
GE Healthcare IN Cell 6000 Analyzer
Molecular Devices ImageXpress Micro Confocal
Molecular Devices ImageXpress Confocal HT.ai
3i Multiphoton-FLIM Optical Metabolic Imaging
Tecan EVO100
Tecan EVO 200
Tecan Hydrospeed Plate Washers
Tecan M1000 Pro Multifunction Reader + Dual injectors + AlphaScreen
BioTek Synergy Neo2 Multifunction Reader + Dual injectors + AlphaScreen
Thermo Multidrop Combi Dispensers
BioTek ELX405 SelectCW Plate washers
Liconic Wave Cell Incubator
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