Texas A&M Health Science Center
2121 W. Holcombe Blvd
Texas A&M Institute of Biosciences and Technology
Houston, TX 77030
United Stateshttps://vpr.tamu.edu/core_facility/high-throughput-research-and-screening-center/cite this facility
Clifford Stephan
Last Updated: 04/27/2022
The Combinatorial Drug Discovery Program (CDDP) resides in the Texas A&M Health Science Center’s Institute of Biosciences and Technology, Houston, TX. This core provides industry standard high throughput screening and automated microscopy capabilities to scientists performing drug discovery research. The core provides many benefits, such as access to an automated infrastructure that is capable of supporting both both phenotypic and biochemical targets. The CDDP provides ready access to collections of current FDA-approved drugs and clinical candidates exhibiting the ‘drug-like’ qualities of acceptable solubility, desirable ADME/toxicology properties and adequate bioavailability. These properties are important for rapid advancement of new agents into successful preclinical and clinical trials by discovering new therapeutic vulnerabilities alone or in combinations. The CDDP also has collections of mechanistically annotated informer sets that are pathway specific modulators for studying mechanism of action or target identification. The core also has collections of natural products and diverse sets of small molecules that can be interrogated for new target discovery. The greatest benefit of the core; however, is its fulltime professional staff. The screening team is composed of highly experienced biologists, biochemists, pharmacologists and data scientists with both pharmaceutical industry and academic experience. Each project is individually evaluated and a team of scientists from the CDDP is created to fit the specific needs of the project from assay design and development through primary, secondary and orthogonal screening. The team is committed to providing an integrated and highly collaborative program with every investigator.
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