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Mass Spectrometry Core, Edinburgh Clinical Research Facility (Mass Spectrometry)

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Centre for Cardiovascular Sciences, Queen's Medical Research Institute

47 Little France Crescent, University of Edinburgh

Edinburgh,

United Kingdom

https://www.ed.ac.uk/clinical-research-facility/core-services/mass-spectrometry

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Quicklinks:

https://coremarketplace.org/Clinical-MassSpecCore https://coremarketplace.org/RRID:SCR_021833

Facility LIMS Page

https://ppms.eu/ed/start/

Primary Contact:

Natalie Homer

Last Updated: 05/19/2025

Facility RRID

RRID:SCR_021833

Facility Details

The Mass Spectrometry Core is part of Edinburgh Clinical Research Facility, situated in the Centre for Cardiovascular Sciences in the Queen‘s Medical Research Institute at the University of Edinburgh. We teach and host undergraduate students, MSc and PhD and clinical research fellows the theory and practice of mass spectrometry, chromatography and its applications to clinical and biological research questions.
We have expertise in sample preparation, bioanalysis for targeted small molecule analysis in clinical and pre-clinical studies.
We also provide a service of sample analysis where we operate under Good Clinical Practice for laboratories for clinical studies. Steroids, drugs and endogenous molecules and metabolic pathways in plasma, serum, tissue.
We also carry out research and consulting in Imaging Mass spectrometry with a full workflow of cryostat, MALDI sprayers, a Sublimator a Waters Synapt G2Si, MALDI and DESI and a range of software packages and workflows developed.

Facility Policies

Services are offerred outside of University of Edinburgh

Consulting is offerred outside of University of Edinburgh

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Services offered:

Drug Discovery

ELISA

HPLC

HRAM Mass Spectrometry

Mass Spectrometry

Metabolomics

Facility Equipment

SCIEX 5500 QTRAP 5500 Mass Spectrometer

QTRAP 5500 system Performs multiple reaction monitoring (MRM) for quantitation using this high-sensitivity triple quadrupole system. Identify, characterize, and quantitate metabolites more quickly and easily.Discover and quantitate targeted biomarkers. Enable high-sensitivity full-scan MS, MS/MS, and MS3 with high-selectivity from true triple quadrupole precursor ion (PI) and neutral loss (NL) scans. [Product Link]

RRID:SCR_020517

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Biotage Extrahera liquid handling robot

Automated sample preparation

SCIEX QTRAP 6500+ Mass Spectrometer

quadruople mass spectrometer

Citation IDs: 107049/Z/15/Z

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SCIEX QTRAP 7500+

mass spectrometer

Thermo Scientific Exploris Orbitrap 240 mass spectrometer

Orbitrap mass spectrometer

Thermo Scientific STELLAR

mass spectrometer

Waters Synapt G2Si

mass spectrometer

Waters Xevo TQS

Mass Spectrometer

SCIEX 6500+ QTRAP 6500+ Mass Spectrometer; Waters Synapt G2Si Mass Spectrometer;
Waters Xevo TQS Mass Spectrometer;
Waters Acquity I-Class;
Waters Acquity Classic;
Biotage Extrahera liquid handling robot

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Publications

Publications associated with this facility (Click To View):

1.) Homer NZ, Nicol M, Madhra M, Naredo-Gonzalez G, Laforest S, Slayden OD, Hillier SG, Walker BR, Warner P, Andrew R, Critchley HO (2025 Apr 9). Luteal phase oral dexamethasone administration alters the endometrial steroid milieu Endocrine Connections, 14(5), e240638. . PMCID: 12007876.

2.) Boyle LD, Miguelez-Crespo A, Paul M, Villalobos E, Toews JN, Ivatt L, Nagy B, Magennis M, Homer NZ, Andrew R, Viau V, Hammond GL, Stimson RH, Walker BR, Nixon M (2025 Jan 9). The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure Nature Communications, 16(), 545. . PMCID: 11718191.

3.) Kyle CJ, Boyle LD, Nixon M, Homer NZ, Simpson JP, Rutter A, Ramage LE, Kelman A, Freel EM, Andrew R, Walker BR, Stimson RH (2024 Nov 15). Proof of concept for a superior therapeutic index of corticosterone compared with hydrocortisone in patients with congenital adrenal hyperplasia European Journal of Endocrinology, 191(6), 535-544. . PMCID: 11606648.

4.) Lovdel A, Suchacki KJ, Roberts F, Sulston RJ, Wallace RJ, Thomas BJ, Bell RM, Pruñonosa Cervera I, Macpherson GJ, Morton NM, Homer NZ, Chapman KE, Cawthorn WP (2024 Jun 24). Deletion of Hsd11b1 suppresses caloric restriction-induced bone marrow adiposity in male but not female mice The Journal of Endocrinology, 262(2), e240072. . PMCID: 11301425.

5.) Denham SG, Simpson JP, Diez F, Lee P, Kyle C, Morgan R, Homer NZ (2024 May 4). A practical approach to supported liquid extraction and measurement of 18 steroids in plasma and serum by targeted liquid chromatography tandem mass spectrometry MethodsX, 12(), 102728. . PMCID: 11214409.

6.) Sandor LF, Huh JB, Benko P, Hiraga T, Poliska S, Dobo-Nagy C, Simpson JP, Homer NZM, Mahata B, Gyori DS (2024 Mar 26). De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis. Cell reports, 43(3), 113936. . PMID: 38489269.

7.) Luo Y, Chatre L, Melhem S, Al-Dahmani ZM, Homer NZ, Miedema A, Deelman LE, Groves MR, Feelisch M, Morton NM, Dolga A, van Goor H (2023 Nov 19). Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain Redox Biology, 68(), 102965. . PMCID: 10701433.

8.) Suchacki KJ, Ramage LE, Kwok TC, Kelman A, McNeill BT, Rodney S, Keegan M, Gray C, MacNaught G, Patel D, Fletcher AM, Simpson JP, Carter RN, Semple RK, Homer NZ, Morton NM, van Beek EJ, Wakelin SJ, Stimson RH (2023 Aug 3). The serotonin transporter sustains human brown adipose tissue thermogenesis Nature Metabolism, 5(8), 1319-1336. . PMCID: 10447248.

9.) Cartwright JA, Simpson JP, Homer NZ, Rossi AG (2023 Jun 8). Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS Journal of Inflammation (London, England), 20(), 20. . PMCID: 10251596.

10.) Baldwin SN, Forrester EA, Homer NZM, Andrew R, Barrese V, Stott JB, Isakson BE, Albert AP, Greenwood IA (2023 Jan). Marked oestrous cycle-dependent regulation of rat arterial K(V) 7.4 channels driven by GPER1. British journal of pharmacology, 180(2), 174-193. . PMID: 36085551.

11.) Ludwig M, Newton C, Pieters A, Homer NZM, Feng Li X, O'Byrne KT, Millar RP (2022 Dec 1). Provocative tests with Kisspeptin-10 and GnRH set the scene for determining social status and environmental impacts on reproductive capacity in male African lions (Panthera leo). General and comparative endocrinology, 329(), 114127. doi: 10.1016/j.ygcen.2022.114127. PMID: 36150474.

12.) Baldwin SN, Forrester EA, Homer NZ, Andrew R, Barrese V, Stott JB, Isakson BE, Albert AP, Greenwood IA (2022 Oct 11). Marked oestrous cycle‐dependent regulation of rat arterial KV7.4 channels driven by GPER1 British Journal of Pharmacology, 180(2), 174-193. . PMCID: 10091994.

13.) Toews JNC, Philippe TJ, Hill LA, Dordevic M, Miguelez-Crespo A, Homer NZM, Nixon M, Hammond GL, Viau V (2022 Oct 11). Corticosteroid-binding Globulin (SERPINA6) Establishes Postpubertal Sex Differences in Rat Adrenal Development. Endocrinology, 163(11), . pii: bqac152. doi: 10.1210/endocr/bqac152. PMID: 36112420.

14.) Ginnell L, O'Carroll S, Ledsham V, Jiménez Sánchez L, Stoye DQ, Sullivan G, Hall J, Homer NZM, Boardman JP, Fletcher-Watson S, Reynolds RM (2022 Jul). Emotion regulation and cortisol response to the still-face procedure in preterm and full-term infants. Psychoneuroendocrinology, 141(), 105760. doi: 10.1016/j.psyneuen.2022.105760. PMID: 35447496.

15.) Carter RN, Gibbins MTG, Barrios-Llerena ME, Wilkie SE, Freddolino PL, Libiad M, Vitvitsky V, Emerson B, Le Bihan T, Brice M, Su H, Denham SG, Homer NZM, Mc Fadden C, Tailleux A, Faresse N, Sulpice T, Briand F, Gillingwater T, Ahn KH, Singha S, McMaster C, Hartley RC, Staels B, Gray GA, Finch AJ, Selman C, Banerjee R, Morton NM (2021 Nov 9). The hepatic compensatory response to elevated systemic sulfide promotes diabetes. Cell reports, 37(6), 109958. . ID: 34758301.

16.) Boulton K, Wilson PW, Bishop VR, Perez JH, Wilkinson T, Hogan K, Homer NZM, Robert C, Smith J, Meddle SL, Dunn IC, Watson K (2021 Oct 26). Parental methyl-enhanced diet and in ovo corticosterone affect first generation Japanese quail (Coturnix japonica) development, behaviour and stress response. Scientific reports, 11(1), 21092. doi: 10.1038/s41598-021-99812-w. ID: 34702953.

17.) Hurst EA, Mellanby RJ, Handel I, Griffith DM, Rossi AG, Walsh TS, Shankar-Hari M, Dunning J, Homer NZ, Denham SG, Devine K, Holloway PA, Moore SC, Thwaites RS, Samanta RJ, Summers C, Hardwick HE, Oosthuyzen W, Turtle L, Semple MG, Openshaw PJM, Baillie JK, Russell CD (2021 Oct 22). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ open, 11(10), e055435. . ID: 34686560.

18.) Puigoriol-Illamola D, Companys-Alemany J, McGuire K, Homer NZM, Leiva R, Vázquez S, Mole DJ, Griñán-Ferré C, Pallàs M (2021 Oct 13). Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice. Pharmaceuticals (Basel, Switzerland), 14(10), . . ID: 34681264.

19.) Gifford RM, O (2021 Aug 1). Reproductive and metabolic adaptation to multistressor training in women. American journal of physiology. Endocrinology and metabolism, 321(2), E281-E291. doi: 10.1152/ajpendo.00019.2021. ID: 34191631.

20.) Meseguer-Ripolles J, Lucendo-Villarin B, Tucker C, Ferreira-Gonzalez S, Homer N, Wang Y, Starkey Lewis PJ, M Toledo E, Mellado-Gomez E, Simpson J, Flint O, Jaiswal H, Beer NL, Karlsen AE, Forbes SJ, Dear JW, Hughes J, Hay DC (2021 Jun 25). Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure. iScience, 24(6), 102552. doi: 10.1016/j.isci.2021.102552. ID: 34151225.

21.) Karailiev P, Hlavacova N, Chmelova M, Homer NZM, Jezova D (2021 Jun). Tight junction proteins in the small intestine and prefrontal cortex of female rats exposed to stress of chronic isolation starting early in life. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 33(6), e14084. doi: 10.1111/nmo.14084. ID: 33497497.

22.) Bell RMB, Villalobos E, Nixon M, Miguelez-Crespo A, Murphy L, Fawkes A, Coutts A, Sharp MGF, Koerner MV, Allan E, Meijer OC, Houtman R, Odermatt A, Beck KR, Denham SG, Lee P, Homer NZM, Walker BR, Morgan RA (2021 Jun). Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice. Molecular metabolism, 48(), 101225. . ID: 33785425.

23.) Faqehi AM, Denham SG, Naredo G, Cobice DF, Khan S, Simpson JP, Sabil G, Upreti R, Gibb F, Homer NZ, Andrew R (2021 Mar 15). Derivatization with 2-hydrazino-1-methylpyridine enhances sensitivity of analysis of 5α-dihydrotestosterone in human plasma by liquid chromatography tandem mass spectrometry. Journal of chromatography. A, 1640(), 461933. . ID: 33588275.

24.) Anderson AJ, Andrew R, Homer NZM, Hughes KA, Boyle LD, Nixon M, Karpe F, Stimson RH, Walker BR (2021 Mar 8). Effects of Obesity and Insulin on Tissue-Specific Recycling Between Cortisol and Cortisone in Men. The Journal of clinical endocrinology and metabolism, 106(3), e1206-e1220. . ID: 33270115.

25.) Sinha R, Lockman KA, Homer NZM, Bower E, Brinkman P, Knobel HH, Fallowfield JA, Jaap AJ, Hayes PC, Plevris JN (2020 Oct). Volatomic analysis identifies compounds that can stratify non-alcoholic fatty liver disease. JHEP reports : innovation in hepatology, 2(5), 100137. doi: 10.1016/j.jhepr.2020.100137. ID: 32775974.

26.) Chen Y, Kunath T, Simpson J, Homer N, Sylantyev S (2020 Oct). Synaptic signalling in a network of dopamine neurons: what prevents proper intercellular crosstalk? FEBS letters, 594(20), 3272-3292. doi: 10.1002/1873-3468.13910. ID: 33073864.

27.) Hutka M, Kadam P, Van Saen D, Homer NZM, Onofre J, Wallace WHB, Smith LB, Stukenborg JB, Goossens E, Mitchell RT (2020 Sep 30). Fertility Preservation in Childhood Cancer: Endocrine Activity in Prepubertal Human Testis Xenografts Exposed to a Pubertal Hormone Environment. Cancers, 12(10), . . ID: 33008013.

28.) Hurst EA, Homer NZ, Mellanby RJ (2020 Sep 15). Vitamin D Metabolism and Profiling in Veterinary Species. Metabolites, 10(9), . . ID: 32942601.

29.) Verma M, Sooy K, Just G, Nixon M, Morgan R, Andrew R, Chapman KE, Homer NZM (2020 Sep). Quantitative analysis of 11-dehydrocorticosterone and corticosterone for preclinical studies by liquid chromatography/triple quadrupole mass spectrometry. Rapid communications in mass spectrometry : RCM, 34(), e8610. doi: 10.1002/rcm.8610. ID: 31677354.

30.) Hurst EA, Homer NZ, Gow AG, Clements DN, Evans H, Gaylor D, Campbell S, Handel I, Mellanby RJ (2020 Jun). Vitamin D status is seasonally stable in northern European dogs. Veterinary clinical pathology, 49(2), 279-291. doi: 10.1111/vcp.12859. ID: 32432371.

31.) Hurst EA, Homer NZ, Denham SG, MacFarlane E, Campbell S, Boswinkel M, Mellanby RJ (2020 May). Development and application of a LC-MS/MS assay for simultaneous analysis of 25-hydroxyvitamin-D and 3-epi-25-hydroxyvitamin-D metabolites in canine serum. The Journal of steroid biochemistry and molecular biology, 199(), 105598. . ID: 31958632.

32.) Laforest S, Pelletier M, Denver N, Poirier B, Nguyen S, Walker BR, Durocher F, Homer NZM, Diorio C, Andrew R, Tchernof A (2020 Apr 1). Estrogens and Glucocorticoids in Mammary Adipose Tissue: Relationships with Body Mass Index and Breast Cancer Features. The Journal of clinical endocrinology and metabolism, 105(4), . . ID: 31853538.

33.) Bode EF, Markby GR, Boag AM, Martinez-Pereira Y, Corcoran BM, Farquharson C, Sooy K, Homer NZM, Jamieson PM, Culshaw GJ (2020 Apr). Glucocorticoid metabolism and the action of 11 beta-hydroxysteroid dehydrogenase 2 in canine congestive heart failure. Veterinary journal (London, England : 1997), 258(), 105456. . ID: 32564866.

34.) Lemos H, Mohamed E, Ou R, McCardle C, Zheng X, McGuire K, Homer NZM, Mole DJ, Huang L, Mellor AL (2020). Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis. Frontiers in immunology, 11(), 1256. doi: 10.3389/fimmu.2020.01256. ID: 32625215.

35.) Laforest S, Pelletier M, Denver N, Poirier B, Nguyen S, Walker BR, Durocher F, Homer NZM, Diorio C, Tchernof A, Andrew R (2019 Dec). Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry. The Journal of steroid biochemistry and molecular biology, 195(), 105476. . ID: 31561001.

36.) Denver N, Homer NZM, Andrew R, Harvey KY, Morrell N, Austin ED, MacLean MR (2020 Jan-Mar). Estrogen metabolites in a small cohort of patients with idiopathic pulmonary arterial hypertension. Pulmonary circulation, 10(1), 2045894020908783. doi: 10.1177/2045894020908783. ID: 32206305.

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Metadata

Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=1248
https://coremarketplace.org/RRID:SCR_021833

Institution

Institution ROR ID: https://ror.org/01nrxwf90

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

USEDit, ABRF, mass spectrometry, targeted small molecule analysis, Imaging Mass spectrometry

Resource Type:

access service resource, core facility, service resource

Citation:

University of Edinburgh Clinical Research Mass Spectrometry Core Facility (RRID:SCR_021833)

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Other Facilities at University of Edinburgh

EdinOmicsRRID:SCR_021838

Services:

Amino Acid Analysis

Assays and Measurements

Automated Liquid Handling

Bioanalytical LC MS/MS

Biochemical Analysis

Consultation

Data Analysis

Data Analysis And Interpretation

Data Processing

Data Processing And Interpretation

Data Visualization

Experimental Design

HPLC

Mass Spectrometry

Mass Spectrometry - Proteins And Peptides

Mass Spectrometry - Small Molecules

Metabolomics

Metabolomics Platform

Natural Product Analysis

Project Management

Proteomics

Proteomics Analysis

Protocol Development

Sample Preparation

Small Molecule Compound Screening

Resources:

Contact Info:

Tessa Moses

Room 1.17, Waddington Building

King's Buildings Campus

Edinburgh, EH93BF - United Kingdom

https://www.ed.ac.uk/biology/research/facilities/edinomics

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RRID:

RRID:SCR_021838

Description:

We are a small research facility based in the School of Biological Sciences and the Centre for Engineering Biology that provides proteomics and metabolomics services for qualitative and quantitative analysis.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

08/02/2023

Mass Spectrometry Core, Edinburgh Clinical Research Facility (Mass Spectrometry)

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Facility LIMS Page

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Facility Equipment

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Publications

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Associations

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Metadata

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Other Facilities at University of Edinburgh

EdinOmicsRRID:SCR_021838

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Mass Spectrometry Core, Edinburgh Clinical Research Facility

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