The CoreMarketplace: BRC Genomics Facility

Full Service DNA Sequencing and Genotyping facility. Offering Sanger,Fragment Analysis, Illumina, RT and Digital PCR, Single Cell, large projects, sample/library prep and QC.

Facility Policies

Services are offerred outside of Cornell University

Consulting is offerred outside of Cornell University

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Services offered:

Nucleic Acid Extraction

Real-time qPCR

RNA analysis

RNAseq

Sequencing - Capillary Sequencing

Sequencing - DNA Sequencing

Sequencing - Next Generation Sequencing (NGS)

Facility Equipment

No additional equipment has been listed

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Publications

Publications associated with this facility (Click To View):

1.) Kelley LH, Caldas IV, Sullenberger MT, Yongblah KE, Niazi AM, Iyer A, Li Y, Tran PM, Valen E, Ahmed-Braimah YH, Maine EM (2024 Oct 7). Poly(U) polymerase activity in Caenorhabditis elegans regulates abundance and tailing of sRNA and mRNA. Genetics, 228(2), . . PMID: 39067069.

2.) Kong S, Zhu M, Scarpin MR, Pan D, Jia L, Martinez RE, Alamos S, Vadde BVL, Garcia HG, Qian SB, Brunkard JO, Roeder AHK (2024 Sep 18). DRMY1 promotes robust morphogenesis in Arabidopsis by sustaining the translation of cytokinin-signaling inhibitor proteins. Developmental cell, (), . pii: S1534-5807(24)00512-4. doi: 10.1016/j.devcel.2024.08.010. PMID: 39305905.

3.) Sprockett DD, Dillard BA, Landers AA, Sanders JG, Moeller AH (2024 Aug 14). Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice. bioRxiv : the preprint server for biology, (), . . PMID: 39185232.

4.) Whitman MA, Mantri M, Spanos E, Estroff LA, De Vlaminck I, Fischbach C (2024 Jul 23). Bone mineral density affects tumor growth by shaping microenvironmental heterogeneity bioRxiv, (), 2024.07.19.604333. . PMCID: 11291034.

5.) Barkley RJR, Crowley JC, Brodrick AJ, Zipfel WR, Parker JSL (2024 Jul 1). Fluorescent protein tags affect the condensation properties of a phase-separating viral protein. Molecular biology of the cell, 35(7), ar100. . PMID: 38809580.

6.) Fang L, Cai S, McMullen P, Hsu YC, Chen MYQ, Jiang S (2024 May 15). Passivating the Background of Living Microbes with a Zwitterionic Peptide for Therapies. Bioconjugate chemistry, 35(5), 575-581. doi: 10.1021/acs.bioconjchem.3c00549. PMID: 38456602.

7.) Gu W, Luozhong S, Cai S, Londhe K, Elkasri N, Hawkins R, Yuan Z, Su-Greene K, Yin Y, Cruz M, Chang YW, McMullen P, Wu C, Seo C, Guru A, Gao W, Sarmiento T, Schaffer C, Nishimura N, Cerione R, Yu Q, Warden M, Langer R, Jiang S (2024 Apr). Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons. Nature biomedical engineering, 8(4), 415-426. doi: 10.1038/s41551-023-01150-x. PMID: 38374224.

8.) Ascenção C, Sims JR, Dziubek A, Comstock W, Fogarty EA, Badar J, Freire R, Grimson A, Weiss RS, Cohen PE, Smolka MB (2024 Feb 23). A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation eLife, 12(), RP90887. . PMCID: 10942628.

9.) Watson NB, Patel RK, Kean C, Veazey J, Oyesola OO, Laniewski N, Grenier JK, Wang J, Tabilas C, Yee Mon KJ, McNairn AJ, Peng SA, Wesnak SP, Nzingha K, Davenport MP, Tait Wojno ED, Scheible KM, Smith NL, Grimson A, Rudd BD (2024 Feb 23). The gene regulatory basis of bystander activation in CD8(+) T cells. Science immunology, 9(92), eadf8776. doi: 10.1126/sciimmunol.adf8776. PMID: 38394230.

10.) Specht DA, Sheppard TJ, Kennedy F, Li S, Gadikota G, Barstow B (2024 Feb 13). Efficient natural plasmid transformation of Vibrio natriegens enables zero-capital molecular biology PNAS Nexus, 3(2), pgad444. . PMCID: 10863642.

11.) Garcia-Bonilla L, Shahanoor Z, Sciortino R, Nazarzoda O, Racchumi G, Iadecola C, Anrather J (2024 Feb). Analysis of brain and blood single-cell transcriptomics in acute and subacute phases after experimental stroke. Nature immunology, 25(2), 357-370. doi: 10.1038/s41590-023-01711-x. PMID: 38177281.

12.) Vu LT, Ahmed F, Zhu H, Iu DSH, Fogarty EA, Kwak Y, Chen W, Franconi CJ, Munn PR, Tate AE, Levine SM, Stevens J, Mao X, Shungu DC, Moore GE, Keller BA, Hanson MR, Grenier JK, Grimson A (2024 Jan 16). Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation. Cell reports. Medicine, 5(1), 101373. . PMID: 38232699.

13.) Danev N, Li G, Duan J(, Van de Walle GR (2024 Jan 12). Comparative transcriptomic analysis of bovine mesenchymal stromal cells reveals tissue-source and species-specific differences iScience, 27(2), 108886. . PMCID: 10838956.

14.) Lee GY, Song J (2024 Jan 3). Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi. bioRxiv : the preprint server for biology, (), . . PMID: 38260632.

15.) Merkuri F, Rothstein M, Simoes-Costa M (2024 Jan 2). Histone lactylation couples cellular metabolism with developmental gene regulatory networks Nature Communications, 15(), 90. . PMCID: 10762033.

16.) Odell J, Gräf R, Lammerding J (2024 Jan 1). Heterologous expression of Dictyostelium discoideum NE81 in mouse embryo fibroblasts reveals conserved mechanoprotective roles of lamins. Molecular biology of the cell, 35(1), ar7. . PMID: 37910203.

17.) van Breugel ME, van Kruijsbergen I, Mittal C, Lieftink C, Brouwer I, van den Brand T, Kluin RJC, Hoekman L, Menezes RX, van Welsem T, Del Cortona A, Malik M, Beijersbergen RL, Lenstra TL, Verstrepen KJ, Pugh BF, van Leeuwen F (2023 Dec 7). Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly. Molecular cell, 83(23), 4205-4221.e9. doi: 10.1016/j.molcel.2023.10.037. PMID: 37995691.

18.) Mitchell SB, Thorn TL, Lee MT, Kim Y, Comrie JMC, Bai ZS, Johnson EL, Aydemir TB (2023 Dec 1). Metal transporter SLC39A14/ZIP14 modulates regulation between the gut microbiome and host metabolism. American journal of physiology. Gastrointestinal and liver physiology, 325(6), G593-G607. . PMID: 37873588.

19.) van Breugel ME, van Kruijsbergen I, Mittal C, Lieftink C, Brouwer I, van den Brand T, Kluin RJ, Hoekman L, Menezes RX, van Welsem T, Cortona AD, Malik M, Beijersbergen RL, Lenstra TL, Verstrepen KJ, Pugh BF, van Leeuwen F (2023 Nov 22). Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA Polymerase III assembly Molecular cell, 83(23), 4205-4221.e9. . PMCID: 11289708.

20.) Ascencao CFR, Sims JR, Dziubek A, Comstock W, Fogarty EA, Badar J, Freire R, Grimson A, Weiss RS, Cohen PE, Smolka M (2023 Nov 22). A TOPBP1 Allele Causing Male Infertility Uncouples XY Silencing Dynamics From Sex Body Formation. bioRxiv : the preprint server for biology, (), . . PMID: 37398453.

21.) Lee S, An L, Soloway PD, White AC (2023 Nov). Dynamic regulation of chromatin accessibility during melanocyte stem cell activation. Pigment cell & melanoma research, 36(6), 531-541. . PMID: 37462349.

22.) Choi S, Whitman MA, Shimpi AA, Sempertegui ND, Chiou AE, Druso JE, Verma A, Lux SC, Cheng Z, Paszek M, Elemento O, Estroff LA, Fischbach C (2023 Nov). Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer. Nature biomedical engineering, 7(11), 1455-1472. doi: 10.1038/s41551-023-01077-3. PMID: 37550422.

23.) Wang KT, Adler CE (2023 Oct 20). CRISPR/Cas9-based depletion of 16S ribosomal RNA improves library complexity of single-cell RNA-sequencing in planarians BMC Genomics, 24(), 625. . PMCID: 10588366.

24.) Shabtai IA, Wilhelm RC, Schweizer SA, Höschen C, Buckley DH, Lehmann J (2023 Oct 19). Calcium promotes persistent soil organic matter by altering microbial transformation of plant litter Nature Communications, 14(), 6609. . PMCID: 10587086.

25.) Superdock DK, Zhang W, Poole AC (2023 Oct 3). Processing and storage methods affect oral and gut microbiome composition Frontiers in Microbiology, 14(), 1253570. . PMCID: 10579807.

26.) González-Tobón J, Helmann TC, Daughtrey M, Stodghill PV, Filiatrault MJ (2023 Oct). Complete Genome Sequence Resource for Xanthomonas hortorum Isolated from Greek Oregano. Plant disease, 107(10), 3259-3263. doi: 10.1094/PDIS-10-22-2399-A. PMID: 37833832.

27.) Carmody CM, Nugen SR (2023 Sep 27). Monomeric streptavidin phage display allows efficient immobilization of bacteriophages on magnetic particles for the capture, separation, and detection of bacteria Scientific Reports, 13(), 16207. . PMCID: 10533843.

28.) Dunn LE, Baines JD (2023 Sep 27). Herpes simplex virus 1 immediate early transcription initiation, pause-release, elongation, and termination in the presence and absence of ICP4 Journal of Virology, 97(10), e00960-23. . PMCID: 10617507.

29.) Wang KT, Adler CE (2023 Jun 16). CRISPR/Cas9-based depletion of 16S ribosomal RNA improves library complexity of single-cell RNA-sequencing bioRxiv, (), 2023.05.25.542286. . PMCID: 10246003.

30.) Chaturbedi A, Lee SS (2023 Jun 14). Different gametogenesis states uniquely impact longevity in Caenorhabditis elegans bioRxiv, (), 2023.06.13.544885. . PMCID: 10312764.

31.) Superdock DK, Zhang W, Poole AC (2023 Jun 14). Processing and Storage Methods Affect Oral and Gut Microbiome Composition. bioRxiv : the preprint server for biology, (), . . PMID: 37398124.

32.) Shimpi AA, Tan ML, Vilkhovoy M, Dai D, Roberts LM, Kuo JC, Huang L, Varner JD, Paszek M, Fischbach C (2023 Jun). Convergent Approaches to Delineate the Metabolic Regulation of Tumor Invasion by Hyaluronic Acid Biosynthesis. Advanced healthcare materials, 12(14), e2202224. . PMID: 36479976.

33.) Walter LD, Orton JL, Hannah Fong EH, Maymi VI, Rudd BD, Elisseeff JH, Cosgrove BD (2023 May 26). Single-cell transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states associated with senescence bioRxiv, (), 2023.05.25.542370. . PMCID: 10245980.

34.) An L, Kim D, Donahue L, Mejooli MA, Chi-Yong E, Nishimura N, White AC (2023 May 22). Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentation bioRxiv, (), 2023.05.22.541644. . PMCID: 10245926.

35.) DeBerardine M, Booth GT, Versluis PP, Lis JT (2023 May 13). The NELF pausing checkpoint mediates the functional divergence of Cdk9 Nature Communications, 14(), 2762. . PMCID: 10182999.

36.) Highland CM, Tan A, Ricaña CL, Briggs JA, Dick RA (2023 Apr 24). Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM Proceedings of the National Academy of Sciences of the United States of America, 120(18), e2220545120. . PMCID: 10160977.

37.) Kong S, Zhu M, Scarpin MR, Pan D, Jia L, Martinez RE, Alamos S, Vadde BV, Garcia HG, Qian SB, Brunkard JO, Roeder AH (2023 Apr 7). DRMY1 promotes robust morphogenesis by sustaining translation of a hormone signaling protein bioRxiv, (), 2023.04.07.536060. . PMCID: 10104159.

38.) Zurier HS, Goddard JM (2023 Apr). A high-throughput expression and screening platform for applications-driven PETase engineering. Biotechnology and bioengineering, 120(4), 1000-1014. doi: 10.1002/bit.28319. PMID: 36575047.

39.) Parker HV, Schaner Tooley CE (2023 Apr). Opposing regulation of the Nα-trimethylase METTL11A by its family members METTL11B and METTL13. The Journal of biological chemistry, 299(4), 104588. . PMID: 36889590.

40.) Shiroor DA, Wang K, Sanketi BD, Tapper JK, Adler CE (2023 Mar 21). Inhibition of ATM kinase rescues planarian regeneration after lethal radiation EMBO Reports, 24(5), e56112. . PMCID: 10157310.

41.) Dunn LEM, Lu F, Su C, Lieberman PM, Baines JD (2023 Feb 28). Reactivation of Epstein-Barr Virus from Latency Involves Increased RNA Polymerase Activity at CTCF Binding Sites on the Viral Genome. Journal of virology, 97(2), e0189422. . PMID: 36744959.

42.) Wallace M, Fedorchak GR, Agrawal R, Gilbert RM, Patel J, Park S, Paszek M, Lammerding J (2023 Feb 21). The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding Nucleus, 14(1), 2180206. . PMCID: 9980629.

43.) Shimpi AA, Tan ML, Vilkhovoy M, Dai D, Roberts LM, Kuo J, Huang L, Varner JD, Paszek M, Fischbach C (2022 Dec 21). Convergent approaches to delineate the metabolic regulation of tumor invasion by hyaluronic acid biosynthesis Advanced healthcare materials, 12(14), e2202224. . PMCID: 10238572.

44.) Chung SS, Bidstrup EJ, Hershewe JM, Warfel KF, Jewett MC, DeLisa MP (2022 Dec 16). Ribosome Stalling of N-Linked Glycoproteins in Cell-Free Extracts. ACS synthetic biology, 11(12), 3892-3899. . PMID: 36399685.

45.) Dunn LEM, Birkenheuer CH, Dufour R, Baines JD (2022 Nov 23). Immediate Early Proteins of Herpes Simplex Virus Transiently Repress Viral Transcription before Subsequent Activation. Journal of virology, 96(22), e0141622. . PMID: 36300939.

46.) Hufziger KA, Farquharson EL, Werner BG, Chen Q, Goddard JM, Nugen SR (2022 Nov 21). In Vivo Capsid Engineering of Bacteriophages for Oriented Surface Conjugation. ACS applied bio materials, 5(11), 5104-5112. . PMID: 36264000.

47.) Hufziger KA, Farquharson EL, Werner BG, Chen Q, Goddard JM, Nugen SR (2022 Oct 20). In vivo capsid engineering of bacteriophages for oriented surface conjugation ACS applied bio materials, 5(11), 5104-5112. . PMCID: 10184791.

48.) Zurier HS, Goddard JM (2022 Oct 4). Directed Immobilization of PETase on Mesoporous Silica Enables Sustained Depolymerase Activity in Synthetic Wastewater Conditions. ACS applied bio materials, (), . doi: 10.1021/acsabm.2c00700. PMID: 36194455.

49.) Hovland AS, Bhattacharya D, Azambuja AP, Pramio D, Copeland J, Rothstein M, Simoes-Costa M (2022 Sep 30). Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells Developmental cell, 57(19), 2257-2272.e5. . PMCID: 9743141.

50.) Mittal C, Lang O, Lai WK, Pugh BF (2022 Sep 1). An integrated SAGA and TFIID PIC assembly pathway selective for poised and induced promoters Genes & Development, 36(17), 985-1001. . PMCID: 9732905.

51.) Pertoldi C, Ruiz-Gonzalez A, Bahrndorff S, Renee Lauridsen N, Nisbeth Henriksen T, Eskildsen A, Høye TT (2021 Sep). Strong isolation by distance among local populations of an endangered butterfly species (Euphydryas aurinia). Ecology and evolution, 11(18), 12790-12800. . PMID: 34594539.

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Associations

ABRF

Association of Biomolecular Resource Facilities

NERLSCD

Northeast Regional Life Science Core Directors

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Metadata

Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=74
https://coremarketplace.org/RRID:SCR_021727

Institution

Institution ROR ID: https://ror.org/05bnh6r87

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

USEDit, ABRF, DNA Sequencing, Genotyping, capillary DNA analysis, single cell applications, long read capabilities

Resource Type:

core facility, service resource, access service resource

Citation:

Cornell University BRC Genomics Core Facility (RRID:SCR_021727)

BRC Genomics Facility (Genomics / Genome Analysis and Technologies)

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Facility Details

Facility Policies

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Facility Equipment

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Publications

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Associations

ABRF

NERLSCD

(To see more facility information, click the in the upper right)

Metadata

SciCrunch Data Imports (data maintained by https://scicrunch.org)

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BRC Genomics Facility

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