The CoreMarketplace: UNE-Rodent Behavior Core

11 Hills Beach Road

Biddeford, ME 04005

United States

207-602-2773

https://une.edu/research/cobre/behavioral

Google Maps Location

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Quicklinks:

https://coremarketplace.org/UNE/BehaviorCore https://coremarketplace.org/RRID:SCR_017883

Facility LIMS Page

https://my.ilabsolutions.com/service_center/6087/?tab=about

Primary Contact:

Denise Giuvelis

Last Updated: 05/19/2025

Facility RRID

RRID:SCR_017883

Additional Citation Identifiers

P30GM145497

Facility Details

The Behavior Core provides a comprehensive approach to the research needs of the Center for Pain Research investigators, UNE researchers, and the external research community using the highest level of expertise, training, and instrumentation. The core provides in-house validation of cutting-edge models of pain and relevant co-morbidities to advance the pain field and early-stage drug discovery.

Services provided include (but are not limited to) the following:
- General Behavioral Phenotyping: Observational Screens, Motor Function
- Pain/Sensory Testing: Thermal, Mechanical, Chemical
- Additional Neurobehavioral Tests: Psychiatric, Addiction, Learning and Memory
- Surgical Models: Neuropathic pain, Post-operative pain
- Miscellaneous Systems: GI Transit, DXA/x-ray scans, and AI video analysis
- Necropsy Services: Perfusions and Post-mortem tissue collection

Other Services:
- Consultation in choosing behavioral test and statistical tests for assessing results
- Training in rodent handling, instrumentation, and behavior or surgical techniques
- Staff expertise includes surgical methods for producing pain models; dosing of drugs/anesthetics including central, systemic and localized administration; and tissue extractions

Facility Policies

Services are offerred outside of University of New England

Consulting is offerred outside of University of New England

Services offered:

Animal Husbandry

Animal Training

Behavioral Assessment

Behavioral Phenotyping

Clinical Imaging - Small Animal (X-ray, Ultrasound, microCAT, MRI)

Cytogenetics

Data Analysis

Data Analysis And Interpretation

Stereotaxic Injection

Surgical Services

Thermal Analysis

Training

Facility Equipment

The Behavior Core is fully equipped for sterile rodent surgeries including SomnoFlo isoflurane vaporizers, a Leica operating microscope, heating pads, surgical instruments and instrument sterilizer in our facility.

In addition to surgical equipment, the core provides numerous instrumentation for behavioral assessments of multiple pain components, including the affective dimensions of pain and pain-suppressed behaviors as well as AI video analysis in an open-field type chamber.

Testing options for thermal & tactile sensitivities in mice and rats include: Thermal - hot water baths, hot/cold plate, and two Plantar Hargreaves apparatuses. Tactile - differential weight bearing assays, and either electronic or manual von Frey filaments with appropriate plastic chambers. We also have a thermal place preference test and COY conflict avoidance test.

Anxiety/Depression testing equipment for mice and rats include: an elevated plus-maze, tail-suspension, and forced swim chambers.

Coordination and activity tests to determine pain-suppressed behaviors: IITC Life Science Rotorod, running wheels, a Coulbourn TRU SCAN open field monitoring system, and a DigiGait Imaging System for treadmill gait analysis.

Motivational state testing equipment for mice and rats include: custom conditioned place preference/aversion chambers, operant chambers, and tub for Morris water maze experiments.

For learning and memory experiments, a Noldus-Ethovision Video Tracking equipment and software allows users to assess animal performance in a number of mazes as well as the novel object recognition test.

In addition to behavioral tests, we offer a wide expertise in a variety of related fields: optogenetics (TeleOpto system), blood collection for PK studies, colony management (breeding strategies, animal identification and tail snips) and necropsy services (perfusions and post-mortem tissue collection).

Please visit our website for a full list of our capabilities.

Publications

Publications associated with this facility (Click To View):

1.) Gomez K, Santiago U, Nelson TS, Allen HN, Calderon-Rivera A, Hestehave S, Rodríguez Palma EJ, Zhou Y, Duran P, Loya-Lopez S, Zhu E, Kumar U, Shields R, Koseli E, McKiver B, Giuvelis D, Zuo W, Inyang KE, Dorame A, Chefdeville A, Ran D, Perez-Miller S, Lu Y, Liu X, Handoko, Arora PS, Patek M, Moutal A, Khanna M, Hu H, Laumet G, King T, Wang J, Damaj MI, Korczeniewska OA, Camacho CJ, Khanna R (2023 Nov 21). A peptidomimetic modulator of the Ca(V)2.2 N-type calcium channel for chronic pain. Proceedings of the National Academy of Sciences of the United States of America, 120(47), e2305215120. . ID: 37972067.

2.) Payne E, Harrington K, Richard P, Brackin R, Davis R, Couture S, Liff J, Asmus F, Mutina E, Fisher A, Giuvelis D, Sannajust S, Rostama B, King T, Mattei LM, Lee JJ, Friedman ES, Bittinger K, May M, Stevenson GW (2021 Nov). Effects of Vancomycin on Persistent Pain-Stimulated and Pain-Depressed Behaviors in Female Fischer Rats With or Without Voluntary Access to Running Wheels. The journal of pain, 22(11), 1530-1544. . ID: 34029686.

3.) Beckley JT, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, Zhou X, Giuvelis D, Meng ID, Yeomans DC, Hunter JC, Mulcahy JV (2021 Apr 1). Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain. Pain, 162(4), 1250-1261. . ID: 33086288.

4.) Nguyen LD, Nolte LG, Tan WJT, Giuvelis D, Santos-Sacchi J, Bilsky E, Ehrlich BE (2021 Jan 27). Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice. Scientific reports, 11(1), 2372. . ID: 33504822.

5.) Mecum NE, Demers D, Sullivan CE, Denis TE, Kalliel JR, Meng ID (2020 Oct 14). Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors. Scientific reports, 10(1), 17225. doi: 10.1038/s41598-020-73945-w. ID: 33057056.

6.) Arabatzis TJ, Wakley AA, McLane VD, Canonico D, Cao L (2020 Jul 6). Effects of HIV gp120 on Neuroinflammation in Immunodeficient vs. Immunocompetent States. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, (), . doi: 10.1007/s11481-020-09936-5. ID: 32627098.

7.) Fitzsimons LA, Brewer VL, Forrester J, Moran AM, Tucker KL (2020 Jun 12). Noninvasive Electrocardiography in the Perinatal Mouse. Journal of visualized experiments : JoVE, (160), . doi: 10.3791/61074. ID: 32597855.

8.) Stevenson GW, Giuvelis D, Cormier J, Cone K, Atherton P, Krivitsky R, Warner E, St Laurent B, Dutra J, Bidlack JM, Szabò L, Polt R, Bilsky EJ (2020 Apr). Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration. Psychopharmacology, 237(4), 1195-1208. . ID: 31912192.

9.) Cirrincione AM, Pellegrini AD, Dominy JR, Benjamin ME, Utkina-Sosunova I, Lotti F, Jergova S, Sagen J, Rieger S (2020 Mar 4). Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation. Scientific reports, 10(1), 3970. doi: 10.1038/s41598-020-60990-8. ID: 32132628.

10.) Beauchemin M, Geguchadze R, Guntur AR, Nevola K, Le PT, Barlow D, Rue M, Vary CPH, Lary CW, Motyl KJ, Houseknecht KL (2020 Feb). Exploring mechanisms of increased cardiovascular disease risk with antipsychotic medications: Risperidone alters the cardiac proteomic signature in mice. Pharmacological research, 152(), 104589. . ID: 31874253.

11.) Davis SM, Rice M, Burman MA (2020 Jan). Inflammatory neonatal pain disrupts maternal behavior and subsequent fear conditioning in a rodent model. Developmental psychobiology, 62(1), 88-98. doi: 10.1002/dev.21889. ID: 31270817.

12.) Huynh PN, Giuvelis D, Christensen S, Tucker KL, McIntosh JM (2019 Dec 21). RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats. Marine drugs, 18(1), . . ID: 31877728.

13.) Rieder CA, Rieder J, Sannajust S, Goode D, Geguchadze R, Relich RF, Molliver DC, King TE, Vaughn J, May M (2019 Nov 28). A Novel Mechanism for Zika Virus Host-Cell Binding. Viruses, 11(12), . . ID: 31795144.

14.) Stackhouse SK, Sweitzer BA, McClure PW (2019 Nov 7). The effect of experimental shoulder pain on contralateral muscle force and activation. Physiotherapy theory and practice, (), 1-8. doi: 10.1080/09593985.2019.1686670. ID: 31696775.

15.) Eaton VE, Pettit S, Elkinson A, Houseknecht KL, King TE, May M (2019 Oct 24). Polymicrobial abscess following ovariectomy in a mouse. BMC veterinary research, 15(1), 364. . ID: 31651316.

16.) Sannajust S, Imbert I, Eaton V, Henderson T, Liaw L, May M, Barbe MF, King T (2019 Sep). Females have greater susceptibility to develop ongoing pain and central sensitization in a rat model of temporomandibular joint pain. Pain, 160(9), 2036-2049. doi: 10.1097/j.pain.0000000000001598. ID: 31430262.

17.) Mecum NE, Cyr D, Malon J, Demers D, Cao L, Meng ID (2019 Aug 1). Evaluation of Corneal Damage After Lacrimal Gland Excision in Male and Female Mice. Investigative ophthalmology & visual science, 60(10), 3264-3274. . ID: 31369671.

18.) Goode DJ, Molliver DC (2019 Jun). Phospho-substrate profiling of Epac-dependent protein kinase C activity. Molecular and cellular biochemistry, 456(1), 167-178. doi: 10.1007/s11010-019-03502-1. ID: 30739223.

19.) Hatta A, Kurose M, Sullivan C, Okamoto K, Fujii N, Yamamura K, Meng ID (2019 Jun 1). Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1. Journal of neurophysiology, 121(6), 2191-2201. doi: 10.1152/jn.00126.2018. ID: 30969886.

20.) Keeley T, Kirov A, Koh WY, Demambro V, Bergquist I, Cotter J, Caradonna P, Siviski ME, Best B, Henderson T, Rosen CJ, Liaw L, Prudovsky I, Small DJ (2019 Apr). Resistance to visceral obesity is associated with increased locomotion in mice expressing an endothelial cell-specific fibroblast growth factor 1 transgene. Physiological reports, 7(7), e14034. doi: 10.14814/phy2.14034. ID: 30972920.

21.) Meng ID, Barton ST, Goodney I, Russell R, Mecum NE (2019 Apr 1). Progesterone Application to the Rat Forehead Produces Corneal Antinociception. Investigative ophthalmology & visual science, 60(5), 1706-1713. . ID: 31013343.

22.) Harrison BJ, Park JW, Gomes C, Petruska JC, Sapio MR, Iadarola MJ, Chariker JH, Rouchka EC (2019). Detection of Differentially Expressed Cleavage Site Intervals Within 3 Frontiers in genetics, 10(), 182. doi: 10.3389/fgene.2019.00182. ID: 30915105.

23.) Knight BE, Kozlowski N, Havelin J, King T, Crocker SJ, Young EE, Baumbauer KM (2019). TIMP-1 Attenuates the Development of Inflammatory Pain Through MMP-Dependent and Receptor-Mediated Cell Signaling Mechanisms. Frontiers in molecular neuroscience, 12(), 220. doi: 10.3389/fnmol.2019.00220. ID: 31616247.

24.) Havelin J, King T (2018 Dec). Mechanisms Underlying Bone and Joint Pain. Current osteoporosis reports, 16(6), 763-771. doi: 10.1007/s11914-018-0493-1. ID: 30370434.

25.) Davis SM, Rice M, Rudlong J, Eaton V, King T, Burman MA (2018 Jul). Neonatal pain and stress disrupts later-life pavlovian fear conditioning and sensory function in rats: Evidence for a two-hit model. Developmental psychobiology, 60(5), 520-533. doi: 10.1002/dev.21632. ID: 29749116.

26.) McLane VD, Kumar S, Leeming R, Rau S, Willis CL, Cao L (2018 Jun 15). Morphine-potentiated cognitive deficits correlate to suppressed hippocampal iNOS RNA expression and an absent type 1 interferon response in LP-BM5 murine AIDS. Journal of neuroimmunology, 319(), 117-129. . ID: 29526406.

27.) Edwards KA, Havelin JJ, Mcintosh MI, Ciccone HA, Pangilinan K, Imbert I, Largent-Milnes TM, King T, Vanderah TW, Streicher JM (2018 Jun). A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain. The journal of pain : official journal of the American Pain Society, 19(6), 612-625. . ID: 29371114.

28.) Cone K, Lanpher J, Kinens A, Richard P, Couture S, Brackin R, Payne E, Harrington K, Rice KC, Stevenson GW (2018 May). Delta/mu opioid receptor interactions in operant conditioning assays of pain-depressed responding and drug-induced rate suppression: assessment of therapeutic index in male Sprague Dawley rats. Psychopharmacology, 235(5), 1609-1618. doi: 10.1007/s00213-018-4876-x. ID: 29572653.

29.) Remeniuk B, King T, Sukhtankar D, Nippert A, Li N, Li F, Cheng K, Rice KC, Porreca F (2018 Apr). Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain. Pain, 159(4), 684-698. doi: 10.1097/j.pain.0000000000001139. ID: 29300279.

30.) Cao L, Malon JT (2018 Feb 21). Anti-nociceptive Role of CXCL1 in a Murine Model of Peripheral Nerve Injury-induced Neuropathic Pain. Neuroscience, 372(), 225-236. . ID: 29309879.

31.) Sherman H, Gitschier HJ, Rossi AE (2018). A Novel Three-Dimensional Immune Oncology Model for High-Throughput Testing of Tumoricidal Activity. Frontiers in immunology, 9(), 857. doi: 10.3389/fimmu.2018.00857. ID: 29740450.

32.) Govea RM, Barbe MF, Bove GM (2017 Oct 1). Group IV nociceptors develop axonal chemical sensitivity during neuritis and following treatment of the sciatic nerve with vinblastine. Journal of neurophysiology, 118(4), 2103-2109. . ID: 28701542.

33.) McLane VD, Bergquist I, Cormier J, Barlow DJ, Houseknecht KL, Bilsky EJ, Cao L (2017 Sep 15). Long-term morphine delivery via slow release morphine pellets or osmotic pumps: Plasma concentration, analgesia, and naloxone-precipitated withdrawal. Life sciences, 185(), 1-7. . ID: 28723417.

34.) Follansbee TL, Gjelsvik KJ, Brann CL, McParland AL, Longhurst CA, Galko MJ, Ganter GK (2017 Aug 30). Drosophila Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(35), 8524-8533. . ID: 28855331.

35.) Allen J, Imbert I, Havelin J, Henderson T, Stevenson G, Liaw L, King T (2017 Jul). Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats. Arthritis & rheumatology (Hoboken, N.J.), 69(7), 1407-1417. doi: 10.1002/art.40101. ID: 28320059.

36.) Cormier J, Cone K, Lanpher J, Kinens A, Henderson T, Liaw L, Bilsky EJ, King T, Rosen CJ, Stevenson GW (2017 Jul 1). Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis. Life sciences, 180(), 51-59. . ID: 28504116.

37.) Lei W, Mullen N, McCarthy S, Brann C, Richard P, Cormier J, Edwards K, Bilsky EJ, Streicher JM (2017 Jun 23). Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain. The Journal of biological chemistry, 292(25), 10414-10428. . ID: 28450396.

38.) Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Pelletier I, Gentry J, Okun A, Tiutan T, Porreca F, King TE (2017 May 17). Mediation of Movement-Induced Breakthrough Cancer Pain by IB4-Binding Nociceptors in Rats. The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(20), 5111-5122. . ID: 28438966.

39.) Malon JT, Cao L (2016 Nov 19). Preparation of Primary Mixed Glial Cultures from Adult Mouse Spinal Cord Tissue. Journal of visualized experiments : JoVE, (117), . doi: 10.3791/54801. ID: 27911395.

40.) Malon JT, Cao L (2016 Aug 15). Calcitonin gene-related peptide contributes to peripheral nerve injury-induced mechanical hypersensitivity through CCL5 and p38 pathways. Journal of neuroimmunology, 297(), 68-75. . ID: 27397078.

41.) Deal AL, Erickson KJ, Shiers SI, Burman MA (2016 Apr). Limbic system development underlies the emergence of classical fear conditioning during the third and fourth weeks of life in the rat. Behavioral neuroscience, 130(2), 212-30. . ID: 26820587.

42.) Zhang Y, Williams DA, Zaidi SA, Yuan Y, Braithwaite A, Bilsky EJ, Dewey WL, Akbarali HI, Streicher JM, Selley DE (2016 Mar 16). 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4 ACS chemical neuroscience, 7(3), 297-304. doi: 10.1021/acschemneuro.5b00245. ID: 26716358.

43.) Havelin J, Imbert I, Cormier J, Allen J, Porreca F, King T (2016 Mar). Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis. The journal of pain : official journal of the American Pain Society, 17(3), 374-82. . ID: 26694132.

44.) Harasawa I, Johansen JP, Fields HL, Porreca F, Meng ID (2016 Jan). Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons. Pain, 157(1), 166-73. doi: 10.1097/j.pain.0000000000000344. ID: 26335909.

45.) Warner E, Krivitsky R, Cone K, Atherton P, Pitre T, Lanpher J, Giuvelis D, Bergquist I, King T, Bilsky EJ, Stevenson GW (2015 Dec). Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding. Drug development research, 76(8), 432-41. doi: 10.1002/ddr.21284. ID: 26494422.

46.) Remeniuk B, Sukhtankar D, Okun A, Navratilova E, Xie JY, King T, Porreca F (2015 Oct). Behavioral and neurochemical analysis of ongoing bone cancer pain in rats. Pain, 156(10), 1864-73. doi: 10.1097/j.pain.0000000000000218. ID: 25955964.

47.) Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R (2015 Aug 13). Structural Requirements for CNS Active Opioid Glycopeptides. Journal of medicinal chemistry, 58(15), 5728-41. doi: 10.1021/acs.jmedchem.5b00014. ID: 26125201.

48.) Camire RB, Beaulac HJ, Willis CL (2015 Jul 15). Transitory loss of glia and the subsequent modulation in inflammatory cytokines/chemokines regulate paracellular claudin-5 expression in endothelial cells. Journal of neuroimmunology, 284(), 57-66. . ID: 26025059.

49.) Motyl KJ, DeMambro VE, Barlow D, Olshan D, Nagano K, Baron R, Rosen CJ, Houseknecht KL (2015 Jul). Propranolol Attenuates Risperidone-Induced Trabecular Bone Loss in Female Mice. Endocrinology, 156(7), 2374-83. doi: 10.1210/en.2015-1099. ID: 25853667.

50.) Stevenson GW, Luginbuhl A, Dunbar C, LaVigne J, Dutra J, Atherton P, Bell B, Cone K, Giuvelis D, Polt R, Streicher JM, Bilsky EJ (2015 May). The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence. Pharmacology, biochemistry, and behavior, 132(), 49-55. . ID: 25735493.

51.) Meng ID, Barton ST, Mecum NE, Kurose M (2015 May). Corneal sensitivity following lacrimal gland excision in the rat. Investigative ophthalmology & visual science, 56(5), 3347-54. . ID: 26024120.

52.) McParland AL, Follansbee TL, Ganter GK (2015 Apr 30). Measurement of larval activity in the Drosophila activity monitor. Journal of visualized experiments : JoVE, (98), e52684. doi: 10.3791/52684. ID: 25993121.

53.) Malon J, Grlickova-Duzevik E, Vaughn J, Beaulac H, Vunk TR, Cao L (2015 Feb 15). Microglial content-dependent inhibitory effects of calcitonin gene-related peptide (CGRP) on murine retroviral infection of glial cells. Journal of neuroimmunology, 279(), 64-70. doi: 10.1016/j.jneuroim.2015.01.010. ID: 25670002.

54.) McParland AL, Follansbee TL, Vesenka GD, Panaitiu AE, Ganter GK (2015). Steroid Receptor Isoform Expression in Drosophila Nociceptor Neurons Is Required for Normal Dendritic Arbor and Sensitivity. PloS one, 10(10), e0140785. doi: 10.1371/journal.pone.0140785. ID: 26495837.

55.) Camire RB, Beaulac HJ, Brule SA, McGregor AI, Lauria EE, Willis CL (2014 Dec). Biphasic modulation of paracellular claudin-5 expression in mouse brain endothelial cells is mediated through the phosphoinositide-3-kinase/AKT pathway. The Journal of pharmacology and experimental therapeutics, 351(3), 654-62. . ID: 25281324.

56.) Draleau K, Maddula S, Slaiby A, Nutile-McMenemy N, De Leo J, Cao L (2014 Jun). Phenotypic Identification of Spinal Cord-Infiltrating CD4+ T Lymphocytes in a Murine Model of Neuropathic Pain. Journal of pain & relief, (), 003. . ID: 25143871.

57.) McLane VD, Cao L, Willis CL (2014 Apr 15). Morphine increases hippocampal viral load and suppresses frontal lobe CCL5 expression in the LP-BM5 AIDS model. Journal of neuroimmunology, 269(1), 44-51. . ID: 24629894.

58.) Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R (2014 Mar 27). Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin? Journal of medicinal chemistry, 57(6), 2237-46. doi: 10.1021/jm400879w. ID: 24576160.

59.) Burman MA, Simmons CA, Hughes M, Lei L (2014 Jan 30). Developing and validating trace fear conditioning protocols in C57BL/6 mice. Journal of neuroscience methods, 222(), 111-7. . ID: 24269252.

60.) Burman MA, Erickson KJ, Deal AL, Jacobson RE (2014). Contextual and auditory fear conditioning continue to emerge during the periweaning period in rats. PloS one, 9(6), e100807. doi: 10.1371/journal.pone.0100807. ID: 24977415.

61.) Meng ID, Kurose M (2013 Dec). The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. Experimental eye research, 117(), 79-87. . ID: 23994439.

62.) Willis CL, Camire RB, Brule SA, Ray DE (2013 Oct 10). Partial recovery of the damaged rat blood-brain barrier is mediated by adherens junction complexes, extracellular matrix remodeling and macrophage infiltration following focal astrocyte loss. Neuroscience, 250(), 773-85. . ID: 23845748.

63.) Largent-Milnes TM, Brookshire SW, Skinner DP Jr, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW (2013 Oct). Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. The Journal of pharmacology and experimental therapeutics, 347(1), 7-19. . ID: 23860305.

64.) Kurose M, Meng ID (2013 Jul). Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells. Journal of neurophysiology, 110(2), 495-504. . ID: 23636717.

65.) Wang Y, Lin L, Lai H, Parada LF, Lei L (2013 Jun). Transcription factor Sox11 is essential for both embryonic and adult neurogenesis. Developmental dynamics : an official publication of the American Association of Anatomists, 242(6), 638-53. doi: 10.1002/dvdy.23962. ID: 23483698.

66.) Ananthan S, Saini SK, Dersch CM, Xu H, McGlinchey N, Giuvelis D, Bilsky EJ, Rothman RB (2012 Oct 11). 14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects. Journal of medicinal chemistry, 55(19), 8350-63. . ID: 23016952.

67.) Lowery JJ, Raymond TJ, Giuvelis D, Bidlack JM, Polt R, Bilsky EJ (2011 Mar). In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice. The Journal of pharmacology and experimental therapeutics, 336(3), 767-78. . ID: 21118955.

68.) Osborn MD, Lowery JJ, Skorput AG, Giuvelis D, Bilsky EJ (2010 Apr 10). In vivo characterization of the opioid antagonist nalmefene in mice. Life sciences, 86(15), 624-30. . ID: 20159022.

69.) Sally EJ, Xu H, Dersch CM, Hsin LW, Chang LT, Prisinzano TE, Simpson DS, Giuvelis D, Rice KC, Jacobson AE, Cheng K, Bilsky EJ, Rothman RB (2010 Apr). Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor. Synapse (New York, N.Y.), 64(4), 280-8. . ID: 19953652.

70.) Bilsky EJ, Giuvelis D, Osborn MD, Dersch CM, Xu H, Rothman RB (2010). In vitro and in vivo assessment of mu opioid receptor constitutive activity. Methods in enzymology, 484(), 413-43. doi: 10.1016/B978-0-12-381298-8.00021-6. ID: 21036244.

71.) Hiebel AC, Lee YS, Bilsky E, Giuvelis D, Deschamps JR, Parrish DA, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Partilla JS, Rothman RB, Cheng K, Jacobson AE, Rice KC (2007 Aug 9). Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series. Journal of medicinal chemistry, 50(16), 3765-76. . ID: 17625813.

72.) Gjelsvik KJ, Follansbee TL, Ganter GK (2018 Jan-Dec). Bone Morphogenetic Protein Glass Bottom Boat (BMP5/6/7/8) and its receptor Wishful Thinking (BMPRII) are required for injury-induced allodynia in Drosophila. Molecular pain, 14(), 1744806918802703. doi: 10.1177/1744806918802703. ID: 30259786.

73.) Wakley AA, Leeming R, Malon J, Arabatzis TJ, Yuen Koh W, Cao L (2018 Sep-Oct). Contribution of CD137L to Sensory Hypersensitivity in a Murine Model of Neuropathic Pain. eNeuro, 5(5), . pii: ENEURO.0218-18.2018. doi: 10.1523/ENEURO.0218-18.2018. ID: 30417077.

74.) Brann CL, Moulton JK, Ganter GK (2019 Jan-Dec). Glypicans Dally and Dally-like control injury-induced allodynia in Drosophila. Molecular pain, 15(), 1744806919856777. doi: 10.1177/1744806919856777. ID: 31132919.

75.) Zuke JT, Rice M, Rudlong J, Paquin T, Russo E, Burman MA (2019 Nov/Dec). The Effects of Acute Neonatal Pain on Expression of Corticotropin-Releasing Hormone and Juvenile Anxiety in a Rodent Model. eNeuro, 6(6), . . ID: 31601633.

Associations

COBRE

Centers of Biomedical Research Excellence

INBRE

IDeA Networks of Biomedical Research Excellence

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Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=758
https://coremarketplace.org/RRID:SCR_017883

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Institution ROR ID: https://ror.org/02n2ava60

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Keywords:

Technical, expertise, training, instrument, assess, behavior, function, nervous, system, acute, chronic, pain, mechanism, phenotypin, motor, learning, memory, cardiovascular, neurobehavioral, respiration, animal, training, genotyping, allele, gene, transgenic, mouse, line, PCR, primer, design, service, core, ABRF

Resource Type:

access service resource, service resource, core facility

Citation:

New England University Behavioral and Genotyping Core Facility (RRID:SCR_017883)

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Other Facilities at University of New England

In Vitro Analytical CoreRRID:SCR_026905

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Hands-on Services

Shared Instrumentation Oversight &

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Training

Resources:

Contact Info:

Ling Cao

11 Hills Beach Road

Biddeford, ME 04005 - United States

https://www.une.edu/research/center-cell-signaling-research/in-vitro-analytical-core

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RRID:

RRID:SCR_026905

Other CIDs:

5P20GM152330-02

Description:

The in Vitro Analytical Core (IVAC) facilitates the mission of the UNE Center for Cell Signaling Research (CCSR) by identifying molecular mechanisms and cellular processes in aging, stress, bioenergetics, and cellular metabolism by providing the critical expertise and instrumentation to study cell-cell interactions and to delineate intracellular pathways in targeted cell types.
The IVAC provides training, instrumentation, and technical services for the development, analysis, and storage of in vitro cell models (such as stably transfected cell lines using genetically encoded biosensors) across a wide range of biological and biomedical applications, as well as various types of sample preparation for downstream analyses such as mass spectrometry and RNA-seq.
Services:
INSTRUMENTATION
• QuantStudio 3 real-time PCR system
• FLIPR Tetra Fluorescent Imaging Plate Reader
• CellInsight CX7 LZR High Content Analysis Platform
• Agilent Seahorse XF HS Mini
• Mammalian Cell Culture Facilities
• General Protein Analysis Equipment
HANDS-ON SERVICES
• Consultations
• Troubleshooting
• Protocol Development
• Cell Line Maintenance and Banking
TRAINING
• Instrumentation Demos
• Individual Hands-On Training
• Workshops
Contact us at ivac@une.edu for more details.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

05/03/2025

UNE Histology and Imaging CoreRRID:SCR_017885

Services:

Cell Imaging

Confocal Microscopy

Consultations

Histology

Immunohistochemistry

Microscopy

Multiphoton Microscopy

Optical Imaging

Whole Slide Imaging

Resources:

Histology

Contact Info:

Peter Caradonna

11 Hills Beach Road

Biddeford, ME 04005 - United States of America

https://www.une.edu/research/cobre/histology

Google Maps Location

RRID:

RRID:SCR_017885

Description:

The Histology and Imaging Core at UNE (part of the Center of Biomedical Research Excellence for the Study of Pain and Sensory Function) is a comprehensive histology and light microscopy facility offering technical expertise and consultation services to UNE researchers and the broader academic & commercial research community. We offer a full range of histology services including cryo, paraffin, and plastic embedding & sectioning, routine/special stains and IHC optimization. Our imaging services span basic brightfield and epifluorescence to laser scanning confocal and 2-photon excitation microscopy. We offer slide scanning/digitization services using our Olympus VS200 slide scanner. Please contact Peter Caradonna (pcaradonna@une.edu) for further inquiries.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

04/27/2022

Microscopy Core FacilityRRID:SCR_017891

Services:

Confocal Microscopy

Resources:

Contact Info:

James Vesenka

122 Pickus Center for Biomedical Research

University of New England

Biddeford, ME 04005 - United States of America

https://sites.google.com/a/une.edu/confocal-microscopy-facility/

Google Maps Location

RRID:

RRID:SCR_017891

Description:

We support an Asylum Research Cypher ES Atomic Force Microscope (2016) with gas, fluid, elasticity, force pulling, and a variety of conductivity/magnetism probe capabilities. We also support a Leica SP5 Scanning Laser Confocal Microscope (2012) with two standard PMTs and one photon counting detector and UV through red excitation sources.

We support and encourage the use of these microscopes in student activities and research both internally and externally. Confocal user fees are found on our website, please contact us with any further information regarding their use.

This facility provides services outside its institution

This facility provides consulting outside its institution

Last updated:

07/05/2016

UNE-Rodent Behavior Core (Behavioral Research)

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Proteomics and Lipidomics CoreRRID:SCR_017730

Mouse Genome Modification Core

Histopathology Core

Molecular Phenotyping

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Other Facilities at University of New England

In Vitro Analytical CoreRRID:SCR_026905

UNE Histology and Imaging CoreRRID:SCR_017885

Microscopy Core FacilityRRID:SCR_017891

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Contact Denise Giuvelis

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UNE-Rodent Behavior Core

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