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University of New England
11 Hills Beach Road
Biddeford, ME 04005United Stateshttps://une.edu/research/cobre/behavioral
Last Updated: 11/30/2020
The UNE Behavioral Core is able to provide investigators and the highest level of technical expertise, training, instrumentation and related services for assessing behavior in rodents. Services provided include (but are not limited to) the following:
- General Behavioral Phenotyping: Observational Screens, Motor Function
- Pain/Sensory Testing: Thermal, Mechanical, Chemical
- Additional Neurobehavioral Tests: Psychiatric, Addiction, Learning and Memory
- Miscellaneous Systems: GI Transit, Cardiovascular and Respiration
- Assistance choosing behavioral test and statistical tests for assessing results.
- Training in surgical techniques for small animal surgeries.
- Staff expertise includes surgical methods for producing pain models; dosing of drugs/anesthetics including central, systemic and localized administration; and tissue extractions.
Services are offerred outside of University of New England
Consulting is offerred outside of University of New England
The Behavior Core is fully equipped for sterile rodent surgeries including an isoflurane vaporizer, a Zeiss operating microscope, heating pads, surgical instruments and instrument sterilizer in our facility.
In addition to surgical equipment, the core provides numerous instrumentation for behavioral assessments of multiple pain components, including the affective dimensions of pain and pain-suppressed behaviors.
Testing options for thermal & tactile sensitivities in mice and rats include: Thermal - hot water baths, hot/cold plate, and two Plantar Hargreaves apparatuses. Tactile - differential weight bearing assays, and either electronic or manual von Frey filaments with appropriate plastic chambers. We also now have a thermal place preference test.
Anxiety/Depression testing equipment for mice and rats include: an elevated plus-maze, tail-suspension, and forced swim chambers.
Coordination and activity tests to determine pain-suppressed behaviors: IITC Life Science Roto-Rod, running wheels, a Coulbourn TRU SCAN open field monitoring system, a DigiGait Imaging System for treadmill gait analysis.
Motivational state testing equipment for mice and rats include: Med Associates conditioned place preference/aversion chambers, NoldusCoy mechanical conflict-avoidance, operant chambers, and tub for Morris water maze experiments.
For learning and memory experiments, a Noldus-Ethovision Video Tracking equipment and software allows users to assess animal performance in a number of mazes as well as the novel object recognition test.
In addition to behavioral tests, we offer a wide expertise in a variety of related fields: optogenetics (TeleOpto system), blood collection for PK studies, colony management (breeding strategies, animal identification and tail snips) as well as genotyping services (NaOH or Proteinase-K purification and PCR or GoTaq PCR reactions).
Please visit our website for a full list of our capabilities.
Publications associated with this facility (Click To View):
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New England University Behavioral and Genotyping Core Facility (RRID:SCR_017883)