Provides researchers with access to laser-scanning confocal, 2-photon, multiplex and epi-fluorescence microscopes. Personnel train individual researchers to use all imaging systems and provide expert help in design, conduct and analysis of imaging studies. As necessary, center personnel can also be hired to conduct microscopy studies for laboratories lacking necessary expertise.

Services include islet isolation services from mice and rats and access to porcine and human islets. The core is equipped with BioRep Perifusion Apparatus for measurement of insulin secretion and offers services for islet and beta cell calcium imaging. Provides services for islet transplantation and assists investigators who wish to perform immunohistochemistry, immunofluorescence and/or analysis of endocrine or beta cell mass on whole pancreata from mouse and rat models.Offers services for rodent metabolic characterization, including performance of insulin and glucose tolerance testing, analysis of body composition, and metabolic cage analysis using the TSE System cages. Recently added services include zebrafish characterization to screen genes and small molecules for their effects on islet development and function.

Core provides imaging services for clinical trials, observational, and preclinical studies. Provides radiochemistry support for molecular imaging. Currently, the Imaging Core is equipped with state-of-the-art imaging systems, including 3T MRI scanners, PET-CT scanners, Bruker 9.4 T preclinical PET-MRI scanner, a Siemens Eclipse Medical Cyclotron, and Radiochemistry Facilities.

Core supports research and development of safe and more efficacious drug treatment. Provides cost-effective and comprehensive services including, but not limited to, on-site breeding facilities as well as in vivo pharmacology models to facilitate development and testing of novel pharmacological and cellular therapies.

Core provides following services: Brachial artery flow-mediated dilation; Brachial artery nitroglycerin-mediated dilation; Carotid artery intima media thickness.

Clinical testing lab that performs targeted metabolomics analyses designed to diagnose and manage patients with inherited metabolic disease.Services include Quantitative Acylcarnitine panel,Quantitative Amino acid panel,Quantitative Methylmalonic acid,Quantitative Free and Total Carnitine Analysis,Semi-Quantitative Urine Organic Acid Profile,Blood Spot Analyte Quantification,Custom Development of Quantitative Metabolite Assays.

Core collaborates with investigators in the planning, statistical design, data management, and analysis of health related clinical, laboratory and epidemiological research projects. Grant development assistance is provided without charge.

Conduct validated and highly reproducible in vitro and in vivo angiogenesis, endothelial, hematopoietic and multi-parametric flow cytometry assays and their role in normal and patient-related hematologic and cardiovascular disorders. The ABC also manages an IncuCyte Zoom and Seahorse XFp.

Provides high-throughput genomics services including: genomic DNA sequencing, transcriptome RNA sequencing, miRNA sequencing, methylome or targeted methylation sequencing, protein DNA/RNA interaction (ChIP-seq, ATAC-seq and CLIP-seq), 10x single cell or single nuclei sequencing, and SNP genotyping.

Provides numerous types of mass-spectrometry based proteomics services, including global proteome quantitation, affinity purification-mass spectrometry, targeted mass spectrometry analysis for precise quantitation, post-translational modification analysis, and a variety of consulting services.

Core provides drug and metabolite concentrations from a variety of biological matrices such as (but not limited to): plasma, urine, CSF, and tissue using HPLC-MS/MS. Additional services include protein binding of drugs, formulation studies, drug stability, drug metabolism, and metabolite screening.

Electrophysiology Core performs rodent brain slice electrophysiological recordings to measure brain cell function.