Core to advance scientific impact of Penn State Cancer Institute investigators by synthesizing and providing chemical agents that are either not commercially available or cost-prohibitive, to facilitate ongoing cancer research. Assists in efforts towards discovering novel agents for treatment and prevention of cancer. Supports activities of development and synthesis of anticancer agents, chemical carcinogens, their detoxification products, reactive species of metabolic activation and DNA adducts formed with such species. Services also include identification and synthesis of biomarkers of uptake and activation of environmental carcinogens that require deuterated, tritiated, and 14C-labeled isotopes.

Cryo-Electron Microscopy Facility houses FEI Titan Krios microscope that offers data collection for life sciences while incorporating materials science applications. Used for creating super high definition 3D images of atoms and molecules. Facility allows for fully automated atomic resolution single particle and high contrast tomography tilt-series data collection. Additional microscopy components permit a full range of materials science applications, including EELS, STEM, and DPC. Facility also houses ThermoFisher Arctica G2.

Penn State’s Center for Applications of Artificial Intelligence and Machine Learning to Industry (AIMI) connects industry members with Penn State’s vast research community of artificial intelligence (AI) and machine learning (ML) researchers and their students to solve real-world problems and seize market opportunities.

Provides access to highly specialized and custom genomics and epigenomics assays that Genomics Core Facility does not currently support. Examples include ATAC sequencing;
RUN sequencing;Tag sequencing;Chromatin immunoprecipitation;Custom assays. Offers hands-on experiences and training for researchers in genomic technologies, methodologies, and instrumentation.

Facility provides infrastructure and support for investigators to undertake single crystal X-ray structural studies. Provides instrumentation, training, and collaboration for Protein characterization, including dynamic light scattering, differential scanning calorimetry, bio-layer interferometry, and circular dichroism; Binding studies using isothermal titration calorimetry; Robotic crystallization, incubators, UV, and digital microscopes;Robotic imaging;
Diffraction data collection and processing; Structure determination and analysis; Molecular modeling; Small angle X-ray scattering. Staff is available to train researchers to use equipment and to assist with project development and research.

Sartorius Cell Culture Facility delivers hands-on training in cell culture to students, faculty, staff, and external personnel, while providing researchers across numerous Penn State disciplines access to the lab environment.

Facility offers highly sensitive and accurate mass spectrometry analysis, including identification and quantitation of proteins by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS-MS) or by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-TOF-MS).

Facility for investigating samples at micrometer scale using in vivo imaging and magnetic resonance microscopy. Facility houses Bruker BioSpec 70/30 horizontal magnet and Agilent 14.1 Tesla vertical magnet.

Facility is equipped with flow cytometers and cell sorters to examine cell samples within range of micron. Staff engage in experimentation, training, project collaboration, and consultation.

Biotechnology pilot plant capable of research and pilot scale production of microbial cells, recombinant proteins, and other microbial products over wide range of controlled conditions. Facility provides equipment and expertise to university affiliated and independent government and industry researchers interested in fermentation and related technologies, including cell separation and disruption, biomolecule production and purification, and process monitoring.

Automated Biological Calorimetry Facility provides infrastructure and support for individual investigators to undertake studies of macromolecule binding and folding, as well as protein and lipid quantification. Our calorimetry instruments are fully automated and require the least amount of sample of any commercially available instruments.Provides instrumentation and collaborative assistance for Isothermal titration calorimetry for studying ligand-macromolecule binding; Differential scanning calorimetry for investigating stability and folding thermodynamics. Staff is available to assist with project development and research.

Microscopy facility specializes in areas of optical microscopy, electron microscopy, and histology. Facility is equipped with confocal microscopes, research fluorescence microscopes, and transmission and scanning electron microscopes. Research staff engage in experimentation, training, project collaboration, and consultation.

Core for conducting metabolomics studies on variety of biofluids and tissue extracts from plant and animal sources. Provided instruments include Agilent 5975C series GC-MSD, Bruker NEO 600 NMR, Thermo Exactive Plus, Thermo Orbitrap Exploris 120, Thermo Orbitrap Exploris 240, Thermo TSQ Quantis Plus, Thermo Orbitrap Fusion Lumos Tribrid.

The Genomics Core Facility provides services using several different next-generation sequencing platforms. Applications supported include:

Whole-genome and transcriptome sequencing of non-model organisms
Amplicon sequencing for metagenomic studies
Differential expression analysis of mRNA and miRNA
Degradome sequencing
ChIP and RIP sequencing