Vanderbilt University
5401 Stevenson Center Ln
Nashville, TN 37212
United States of Americahttps://www.vanderbilt.edu/cit/cite this facility
Stacy D. Sherrod/ Ph.D.
Last Updated: 12/18/2018
The Center for Innovative Technology (CIT) at Vanderbilt University in Nashville, Tennessee is a state-of-the-art small molecule omics (metabolomics, lipidomics) shared resource center and collaborative analytical facility specializing in a range of mass spectrometry and confocal screening techniques.
OUR MISSION is to provide innovative and tailored solutions to analytical challenges using cutting-edge instrumentation and methodologies for academia, government, and industry.
OUR CAPABILITIES include measuring the complex array of small molecule metabolites present within a fluid, cell, or tissue and identifying reproducible steady state and/or temporal changes associated with disease state or drug administration for context dependent analysis. Metabolite identifications are assigned based on high mass accuracy measurements, isotope distributions, tandem MS fragmentation patterns, and comparisons with spectral libraries and standards. Consequently, the results can reveal unique biochemical fingerprints of cellular processes specific to each sample. This can be exploited as a discovery-based approach for generating novel hypotheses or used to better understand physiological processes mediated by genetic or environmental perturbations. If needed, new workflows can be established for method development, targeted biomolecule measurement acquisition, and/or metabolite validation.
We support our clients in numerous phases of the analytical pipeline and provide a number of routine and/or advanced services depending on the goals of your individual research projects.
The CIT focuses on metabolomics and lipidomics-based analyses and provides the infrastructure and expertise to measure both untargeted (discovery) and targeted (validation, quantification) small molecules derived from biospecimens such as cells, tissues, biofluids, and many others.
Our research facility places an emphasis on the use and development of numerous separation technologies coupled to MS including hydrophobic/hydrophilic liquid chromatography (RPLC and HILIC) and ion mobility-mass spectrometry (IM-MS). Our technologies are supported by current state-of-the-art informatics and data analysis software.
The CIT offers a wide range of services including, but not limited to:
- Global untargeted omics analyses (using MS and ion mobility-MS techniques)
- Targeted omics analyses
- High-content screening microscopy
- Custom method development
- Data processing & analysis
- Instrument & data analysis training
Services are offerred outside of Vanderbilt University
Consulting is offerred outside of Vanderbilt University
