We provide a multi-user facility, open to qualified academic scientists, fee for use.

The BUH-COBRE on Opioids and Overdose Admin Core is a shared research resource of the COBRE on Opioids and Overdose at Brown University Health. The Administrative Core provides centralized research administration, project management, regulatory support, grant development assistance, compliance tracking, investigator development, and coordination of COBRE activities. The Core supports pilot projects, Research Project Leaders (RPLs), scientific meetings, reporting requirements, communications, dissemination activities, and collaboration across all COBRE cores to advance opioid and overdose-related research.

The BUH-COBRE Translational & Transformative Research Core is a shared research resource of the COBRE on Opioids and Overdose at Brown University Health. The Core supports the translation of research findings into clinical practice, community implementation, and public health impact. Services include qualitative research consultation, implementation and dissemination support, development of recruitment and educational materials, video production services, access to specialized research resources, and drug-checking research support.

The BUH-OPIOID-COBRE DRM Core is a shared research resource of the COBRE on Opioids and Overdose at Brown University Health. The Data & Research Methods Core provides expertise in biostatistics, epidemiology, study design, data management, data visualization, and quantitative research methods. Services include statistical consultation, power and sample size estimation, analytic support, data infrastructure guidance, data collection strategies, and training for investigators conducting substance use, overdose, and related public health research.

The BUH-COBRE Community Engagement Core is a shared research resource of the COBRE on Opioids and Overdose at Brown University Health. The Core supports community-engaged research by connecting investigators with community partners, people with lived and living experience, healthcare organizations, and other stakeholders. Services include community consultation, Community Advisory Board support, participant recruitment and retention strategies, dissemination planning, stakeholder engagement, and guidance on equitable and ethical research practices.

Core supports mechanistic human laboratory studies and randomized clinical trials by identifying, coordinating, and providing the scientific expertise, clinical and technical capabilities, and other resources needed for their research projects.

The Rhode Island Biobank is a state of the art cryogenic facility for human tissue and fluid samples located at Brown University in Providence, RI. It is a core facility under the management of the Division of Biology & Medicine and supports biomedical research on the Brown campus and across the affiliated hospitals of the Warren Alpert Medical School.

The mission of the Rhode Island BioBank is to provide a secure, centralized biorepository and bioregistry for tissues and fluids that will be available for biomedical research by investigators at Brown University, local area hospitals and beyond.

The LC/MS Proteomics Core Facility‘s (PCF) mission is to provide well-maintained, state-of-the-art instrumentation and fundamental proteomics expertise to the Brown University and Rhode Island scientific communities. We aim to be a focal point of intellectual activity in proteomics by enabling nationally recognized proteomics research within Rhode Island. We welcome inquiries from scientists and teachers seeking information regarding how we may assist them in furthering their research and educational goals. The facility‘s function is catalyzed by its Administrative Directors, Faculty advisor, responsible Facility Director, and a knowledgeable advisory committee. Together their research interests are based on the pursuit and implementation of proteomics approaches to biological inquiry.

As an NSF EPSCoR-funded laboratory, the Proteomics Facility has a broadly inclusive philosophy to ensure rapid and equal access to the facility‘s services for the entire Rhode Island research community. In addition to the acquisition of new instrumentation, the Proteomics Core Facility will undertake research in emerging proteomic techniques to maintain a productive and professional level of service. The PCF has a strong commitment to be at the leading edge of current and developing technologies and provides consultative services to users.

The Genomics Core Facility, located at 70 Ship Street, Room 109, provides state-of-the-art genomics and proteomics equipment and services to researchers at Brown University, the entire Rhode Island research community and external customers.

The facility offers DNA/RNA shearing, sample QC, Affymetrix microarray, qPCR services and provides assistance with experimental design, trouble shooting, and data analysis. Please see our menu for detailed information on the services offered, instruments available and current rates.

The core is available to students, staff and faculty at Brown as well as researchers from RI-EPSCoR institutions. Training is provided for new users. We welcome investigators to contact us regarding our services.

The purpose of this facility is to provide technical assistance to Brown researchers by performing flow cytometry-based analysis and sorting. The facility has a 4-laser, 19-parameter BD FACSAria III for flow and sorting applications.

The Structural Biology Core Facility at Brown University provides state-of-the art equipment for researchers at Brown University and the surrounding area. Our instruments can be used for structural modeling in crystals and in solution, using X-ray diffraction and scattering, as well as magnetic resonance.

The Leduc Bioimaging Facility, open to all investigators, provides equipment and training dedicated to high-resolution imaging in the life sciences. The facility includes a Transmission Electron Microscope, a Scanning Electron Microscope, two Fluorescence Microscopes, a Fluorescence Stereomicroscope, three Confocal Laser Scanning Microscopes, a Multiphoton Microscope, and software for image analysis. The facility also maintains equipment for sample preparation, including a critical point dryer, sputter coater, and microtomes for ultrathin sectioning.

Our core provides specialty immunohistochemical services, instrumentation, training and support personnel for the research efforts of the COBRE CCRD mentors and their junior associates as well as the academic community at large. We are located on the sixth floor of the Aldrich Building within the main campus of Rhode Island Hospital. Our equipment includes an ArcturusXT laser capture microdissector, Stratagene MX3005p realtime PCR instrument, BioRad iCycler, Agilent Bioanalyzer, Olympus fluorescence-capable microscope with image analysis software, Ventana Discovery immunohistochemistry processor, microtome, cryostat, Beecher tissue arrayer and Aperio ScanScope. Our tissue bank has 40 cu ft of ultra-low freezer space and provides human tumor tissue samples to all interested investigators who have received IRB approval for academic testing and research.

The COBRE for Skeletal Health and Repair in the Rhode Island Hospital enables clinicians and basic scientists, engineers and biologists to work side-by-side on multidisciplinary research, helping us to better understand cartilage and joint health mechanisms and develop strategies for the prevention and treatment of skeletal joint diseases.

Specific Aims:
-Provide sophisticated, state-of-the-art instrumentation in microscopic imaging and molecular analysis to different projects in the COBRE.
-Provide technical support and expert consultation in tissue, cell, and molecular, analysis to multidisciplinary users including biologists, clinicians and engineers.
-Provide training of cutting edge techniques in molecular and morphological analysis to investigators for achieving specific research objectives.
-Facilitate collaborations among different laboratories and disciplines through utilizing common equipment and analyzing techniques.

Core provides investigators with access to specialized expertise in primary cell isolation, ex vivo organ function assessment, histology, and advanced tissue imaging. The Core supports cardiovascular, pulmonary, and vascular research through customized experimental services, consultation, and rigorous functional and molecular analyses that accelerate mechanistic discovery and translational research.