primary_duns:
824771034
Elm & Carlton Streets
Buffalo, NY 14263-0001
United Stateshttps://www.roswellpark.org/shared-resources/translational-imagingcite this facility
Joseph Spernyak
The Translational Imaging Shared Resource (TISR) provides specialized preclinical imaging services including image acquisition, quantitative image analysis, multidimensional renderings and data sets for research purposes.
is_active:
Yesbudget_end:
04/30/2026date_added:
08/02/2025agency_code:
NIHfiscal_year:
2025project_num:
5P30CA016056-48award_amount:
$4,468,904.00budget_start:
05/01/2025org_name:
ROSWELL PARK CANCER INSTITUTE CORPorg_state:
NYorg_country:
UNITED STATESorg_zipcode:
142630001primary_duns:
824771034abstract_text:
Roswell Park Comprehensive Cancer Center (Roswell Park), established in 1898 is one of a small number of freestanding, NCI-designated, comprehensive cancer centers and the only comprehensive center in New York State (NYS) outside of Manhattan. The sole mission of the Center is to eliminate cancer's grip on humanity through cancer research, treatment, prevention and education. The Cancer Center which is in its 46th year of funding, is currently organized around 4 research programs, 9 shared resources, a clinical trial infrastructure that prioritizes investigator-initiated and innovative clinical trials that are a product of the research programs and a community outreach and engagement (COE), Cancer Research Training & Education Coordination (CRTEC) that are interactive, cross-functioning and responsive to our catchment area. The Cancer Center supports 145 members and has recruited 162 new faculty since the previous review with 42 of them new members of the CCSG. Our cancer-relevant direct grant funding is currently $79M with 49% ($39M) coming from the NCI, a more than doubling of our NCI funding from 2018 with over 56% of funding in program/multi-PI type grants that underscores our commitment to collaborative research. Our high impact papers have increased to 29% from 10% in 2018 resulting in practice, paradigm and policy changing research. We have increased our focus on our community outreach and engagement, and we have an enhanced approach to our community and catchment area needs. The Specific Aims over the next 5 years are as follows: Aim 1: Innovation: To be a leader in the development of innovative approaches in cancer research across basic, clinical and population sciences to improve the quality of care for our patients in our catchment area and beyond. Aim 2: Translation: To enhance collaborative efforts between basic, clinical and population scientists toward the more effective translation of our discoveries into paradigm changing patient practices and interventions and policies. Aim 3: Education: To train and develop the next generation of scientists and physicians through innovative oncology-focused programs that continue to develop translational opportunities across the clinic, the basic science and population science areas. Aim 4: Community: To ensure that the needs and priorities of communities in our catchment area are catalyzing high- impact science with a specific focus on strategies drive rapid translation of scientific advances to reduce the cancer burden in our catchment area and beyond. Aim 5: To promote a culture of fairness, accountability, integrity and respect across our cancer center employees, scientists, physicians, nurses and healthcare staff, students and trainees and leadership toward a more productive workplace and to serve our community more effectively. Roswell Park continues to play a primary role in discovery and innovation in basic science findings that enable us to deliver the best cancer care to our patients in New York State, around the country and around the world.project_title:
Roswell Park Cancer Center Support Grantcontact_pi_name:
JOHNSON, CANDACE Stotal_cost:
$4,468,904.00is_active:
Nobudget_end:
03/31/2023date_added:
04/03/2021agency_code:
NIHfiscal_year:
2021project_num:
1S10OD030397-01award_amount:
$2,000,000.00budget_start:
04/01/2021org_name:
ROSWELL PARK CANCER INSTITUTE CORPorg_state:
NYorg_country:
UNITED STATESorg_zipcode:
142630001primary_duns:
824771034abstract_text:
Project Summary The purpose of this S10 grant application is to secure funding to replace a technically outdated 4.7T magnetic resonance imaging (MRI) scanner for the Translational Imaging Shared Resource (TISR) at Roswell Park Comprehensive Cancer Center. For nearly two decades, the TISR at Roswell Park has been providing customized scientific and technical preclinical imaging services on a fee for service basis to NIH funded investigators at Roswell Park, the State University of New York at Buffalo and neighboring academic institutions in Western New York. It is a heavily utilized by over 50 Roswell Park and UB faculty members who are conducting basic and translational investigations in oncology and radiology. The existing 4.7T magnet was purchased through a combination of institutional and state funds and was the first MR scanner installed in WNY dedicated for preclinical research. Since 2001, TISR has catered to the imaging needs of 168 users, out of whom 105 utilized the existing 4.7T MR scanner. However, this aging instrument has encountered two soft quenches in the last 10 years, and has outdated electronics that lack upgrading capabilities. These limitations pose a significant risk to faculty and research programs at the only NCI designated Comprehensive Cancer Center in the state of New York outside of Manhattan. Another technical failure of the present ~20-year-old MR scanner would be catastrophic and seriously jeopardize the conduct of active NIH/NCI funded research at Roswell Park and prevent our faculty from pursuing new projects utilizing MRI for anatomic, functional and molecular imaging of cancer. Acquisition of an upgraded instrument is therefore a critical need that will not only enable TISR to meet the existing demand for this imaging technology but also facilitate further growth of TISR.project_title:
Acquisition of a 7T MR scanner for Translational Imaging Research at Roswell Parkcontact_pi_name:
SESHADRI, MUKUNDtotal_cost:
$2,000,000.00is_active:
Nobudget_end:
08/31/2014date_added:
09/08/2013agency_code:
NIHfiscal_year:
2013project_num:
1S10OD016450-01award_amount:
$406,356.00budget_start:
09/01/2013org_name:
ROSWELL PARK CANCER INSTITUTE CORPorg_state:
NYorg_country:
UNITED STATESorg_zipcode:
142630001primary_duns:
824771034abstract_text:
DESCRIPTION (provided by applicant): Roswell Park Cancer Institute seeks to obtain funds for the purchase of the IVIS(R) Spectrum optical imaging system. The system will be overseen by Dr. Joseph Spernyak of the Small Animal Bio-Imaging Resource (SABIR). SABIR has been in operation for over 10 years as a core resource at Roswell Park and is thus well-suited to maintain the equipment and train new users. Use of optical imaging in preclinical models allows for the acceleration of translating novel drugs and biophysical therapies from the "bench top to the bedside." We have identified multiple NIH-funded researchers comprised of diverse backgrounds and research interests that will benefit significantly from this machine. The IVIS(R) Spectrum system will provide a considerable expansion in the optical imaging capabilities currently available at Roswell Park, specifically a) more efficient and sensitive bioluminescent imaging, b) near-infrared fluorescent imaging with spectral unmixing capabilities, c) quantitative fluorescent imaging via trans- illumination techniques and d) 3D optical tomography for localization of emission signal and co- registration to magnetic resonance imaging data. The system will be strategically sited within the Resource to allow serial optical imaging and MR imaging in the same animal and imaging session, taking advantage of the complementary advantages of optical (high sensitivity) and MR (high resolution, excellent soft-tissue contrast) imaging modalities.project_title:
IVIS Spectrum Imaging Systemcontact_pi_name:
SPERNYAK, JOSEPH ANDREWtotal_cost:
$406,356.00is_active:
Nobudget_end:
05/14/2013date_added:
05/20/2012agency_code:
NIHfiscal_year:
2012project_num:
1S10OD010393-01award_amount:
$596,032.00budget_start:
05/15/2012org_name:
ROSWELL PARK CANCER INSTITUTE CORPorg_state:
NYorg_country:
UNITED STATESorg_zipcode:
142630001primary_duns:
824771034abstract_text:
DESCRIPTION (provided by applicant): The purpose of this NCRR Shared Instrument Grant application is to secure funding to purchase a Small Animal Photoacoustic Imaging system (Vevo(R)LAZR) for the Shared Tumor Imaging Resource (STIR) at Roswell Park Cancer Institute (RPCI). The STIR at RPCI provides customized scientific and technical small animal imaging services on a fee for service basis to NIH funded investigators at RPCI, the State University of New York at Buffalo (SUNY-Buffalo) and neighboring academic institutions in Western New York. Since 2005, the STIR has seen a steady growth in its utilization as a result of increased awareness of its imaging technologies achieved through active collaborations with institutional faculty and educational outreach programs instituted by STIR and RPCI. However, this positive change has also highlighted the need for state- of-the-art imaging technology to meet the expanding needs of RPCI research community. The Vevo LAZR platform is a high sensitivity system specifically designed for small animal imaging at a high resolution. In addition to anatomic or morphologic assessment of tumors, the system allows for molecular functional imaging of the tumor microenvironment in small animal models of disease. The sophisticated software platform allows for visualization and quantitative analysis of imaging datasets in an efficient and user-friendly manner. With the increased interest in personalized medicine and molecular targeted therapies for cancer, several NIH-funded programs at RPCI and SUNY-Buffalo are focused on understanding the changes in the tumor microenvironment during malignant progression and following therapy. These projects, some of which have been detailed in this application, will utilize the Vevo(R)LAZR system to (i) detect occult metastatic lesions in disease sites such as the kidney and liver, (ii) assess longitudinal changes in tumor morphology following treatment, (iii) visualize and quantify changes in tumor blood flow, (iv) map sentinel lymph nodes and lymphatics, (v) measure parameters such as oxygenation and hemoglobin saturation in tumors, and, (vi) investigate tumor-targeting ability of multifunctional nanoparticle. The availability of a user-friendly, portable imaging system at STIR would enable its users to effectively combine high-throughput anatomic imaging with quantitative, functional molecular imaging of tumors. Acquisition of the photoacoustic imaging system will not only enable STIR to meet the existing demand for this imaging technology but also facilitate further growth of STIR by increasing its imaging services and technologies available to researchers. PUBLIC HEALTH RELEVANCE: A high-resolution, high sensitivity photoacoustic imaging system is requested for the Shared Tumor Imaging Resource at Roswell Park Cancer Institute (RPCI). The availability of a user-friendly, portable imaging system would enable multiple NCI/NIH-funded investigators at RPCI to effectively combine high throughput anatomic imaging with quantitative, functional molecular imaging for cancer research applications.project_title:
Photoacoustic Micro-Imaging system for Shared Tumor Imaging Resource at Roswell Pcontact_pi_name:
SESHADRI, MUKUNDtotal_cost:
$596,032.00Services are offerred outside of
Consulting is not offerred outside of Roswell Park Comprehensive Cancer Center
Last Updated: 05/01/2026
