Facility Details

The mission of the VAI Transgenic Core is to provide genetically modified animal models for our collaborators in support of their research.

When these models are preexisting this provision can take the form of rederivation or reconstitution for the purpose of importing animals into our Vivarium’s barrier.

In the absence of preexisting models our Core works closely with partnering labs to generate their ideal mutation de novo, often using CRISPR technology. Usually beginning with a brief consultation, this process involves discussing factors such as ideal background strain, molecular methods for optimizing the intended genetic change, mutation induction strategies, screening approaches and eventual QC of the new mutant line with the overall goal of giving our collaborators a fully informed, realistic picture of their projects timeframe, pitfalls and workflow.

Additionally, our Core provides mouse sperm and embryo cryopreservation services for the purpose of archiving and distributing valuable lines.

The Van Andel Institute is an AAALAC-accredited facility. All procedures are conducted according to the NIH Guide for the Care and Use of Laboratory Animals. We understand how important excellence in animal care is for producing quality research and are committed to the highest quality standards in pursuit of this principle.