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All Facilities >> University of North Carolina at Chapel Hill >> UNC Biospecimen Processing Facility (Nucleic Acid)
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Cortney Pylant
Last Updated: 07/06/2022
We are CAP Accredited!
The UNC BSP is a centralized, quality-controlled facility and biorepository for the processing, storage and disbursement of human specimens. The facility is geared for high throughput processing of human biospecimens, with specific emphasis on DNA and RNA isolation and purification.
The Facility provides laboratory support for investigator-initiated large-scale clinical, epidemiologic, and other studies. We also function as a human specimen biorepository resource for clinicians who wish to store and study samples from unusual or potentially important patients. Our biorepository is managed by a custom LIMS, with sample accessioning, tracking and audits at each step.
In addition to laboratory services, the facility provides a scientific resource for investigators seeking advice/consultation on study design including specimen collection and storage methods, and human subject issues. Core staff act as a liaison to other UNC core facilities and outside collaborators.
Our mission is to provide a cost-effective UNC facility to process biospecimens from population, clinical, and other studies.
Services are offerred outside of University of North Carolina at Chapel Hill
Consulting is offerred outside of University of North Carolina at Chapel Hill
Agilent 4200 TapeStation System
TapeStation System is used to analyze DNA and RNA samples for quality control. [Product Link]
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Applied Biosystems GeneAmp 9700 PCR Thermocycler System
Automated PCR instrument for automated amplification of nucleic acids with Polymerase Chain Reaction. It has reaction volumes of up to 50 uL and sample temperature range of 4 to 99.9 C. [Product Link]
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Spectramax M2e Microplate Reader
SpectraMax M2 and M2e Systems from Molecular Devices are multidetection microplate readers with dualmonochromators, dual-mode cuvette ports, and top- and bottom-reading capability (top-reading only on the M2). Detection modalities include absorbance (UV-Vis Abs) and fluorescence intensity (FI). [Product Link]
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2 x Perkin-Elmer Chemagic MSM I for automated high throughput DNA and RNA isolation systems, based on proprietary M-PVA magnetic bead technology. Provides ultra-clean DNA and RNA preps from saliva, mouthrinses, small tissues, frozen blood and buffy coats. (https://chemagen.com/chemagic-msm-i/)
Purigen Biosystem’s Ionic Purification System for automated purification of nucleic acids from small cell numbers and FFPE scrolls or slides requires less than 3 minutes of hands-on time per sample (lysis included). No chemical deparaffinization is required for DNA and RNA purification with this system. In addition, DNA and RNA are automatically separated and concentrated from sample lysate in 60 minutes. (https://www.purigenbio.com/)
Perkin-Elmer Janus liquid handling robot for DNA and RNA plating and normalization (https://www.perkinelmer.com/category/janus-liquid-handler-workstations)
Denovix DS-11FX Spectrophotomer/Fluorometer (https://www.denovix.com/products/ds-11-fx-spectrophotometer-fluorometer/). Performs standard DNA and RNA OD measurements, as well as fluorometric DNA and RNA quantitation.
Caliper LabChipDs with CDrop software
Scilogex SCI-100HCM-Pro Digital Thermal Mixer
Micronic VX2 automated labeler
Monitored freezer (-80° C and liquid nitrogen) capacity for >500,000 cryovials. Common specimens stored include: DNA, RNA, urine, plasma, serum, whole blood, PBMC, cell pellets, and FFPE slides.
Custom LIMS for sample accessioning, tracking, and audits for all processed samples and those stored in the biorepository.
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https://coremarketplace.org/?FacilityID=1186Institution
Institution ROR ID: https://ror.org/0130frc33Keywords:
USEDit, ABRF
Resource Type:
core facility, service resource, access service resource
Citation:
University of North Carolina at Chapel Hill Biospecimen Processing Core Facility (RRID:SCR_021290)
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Facility Details
About This Facility
Services and Equipment
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