The University of Delaware Bio-Imaging Center is a multi-user microscopy facility that houses state-of-the-art microscopy equipment. Our mission is to maintain state-of-the-art microscopy instrumentation and skilled staff scientists to assist and train researchers on all aspects of microscopy, including experimental design, sample preparation, imaging on microscopes, image analysis, data interpretation, and publication.
With a special emphasis on life sciences and soft materials, we are able to address the broad imaging needs of the university, non-profit and industrial research community. The center is open to all academic researchers and industrial clients on a fee-for-service basis. The center is housed at the Delaware Biotechnology Institute in the Ammon Pinizzotto Biopharmaceutical Innovation Center at the University of Delaware.
Funding Info
NIH - 07/26/2025 - Delaware INBRE
is_active:
Yes
budget_end:
04/30/2026
date_added:
07/26/2025
agency_code:
NIH
fiscal_year:
2025
project_num:
2P20GM103446-24
award_amount:
$4,360,371.00
budget_start:
07/25/2025
org_name:
UNIVERSITY OF DELAWARE
org_state:
DE
org_country:
UNITED STATES
org_zipcode:
197131325
primary_duns:
059007500
abstract_text:
Project Summary
The Delaware IDeA Network of Biomedical Research Excellence (DE-INBRE) catalyzes multidisciplinary
biomedical research initiatives that build Delaware’s biomedical research capacity and workforce. The DE-
INBRE network consists of five network partner institutions (NPIs): The University of Delaware, a Carnegie R1-
doctoral intensive- very high research activity university which also has three associate-in-arts campuses,
leads the DE-INBRE program in partnership with two minority-serving primarily undergraduate institutions
(PUIs), Delaware State University (DSU) and Delaware Technical Community College, along with two medical
institutions, Christiana Care Health System and Nemours Children’s Health-Delaware. DE-INBRE’s
Administrative (ADMIN) core provides logistic/administrative support to all DE-INBRE activities while ensuring
compliance with all federal, state and institutional policies, administers a robust Student Research Program
that provides mentored scientific research internships to Delaware’s undergraduates, a comprehensive set of
Professional Development workshops that foster the success of scientists ranging from undergraduates
through faculty, and an Evaluation program that ensures that all DE-INBRE programs are contributing to its
mission. The Data Science core supports computational resources, access to biomedical datasets, data
science consulting, and the development/dissemination of workshops that train investigators in data science
methodology. The Renovation component supports the physical infrastructure needed for DSU to establish at
Data Science Laboratory to foster expansion of Data Science research at this HBCU. The DRPP program
administers a research grant program that provides seed funding to Delaware’s early stage and new
investigators to launch successful biomedical research careers. The Centralized Shared Resources core
ensures that Delaware’s scientific community has ready access to a network of 20 core facilities located across
Delaware by supporting policies that keep core access open to investigators at all NPIs, vouchers to support
investigator core use, training of core facility staff in core management and new technologies. All DE-INBRE
components synergize into a robust initiative that will make a major impact on Delaware’s research community.
project_title:
Delaware INBRE
contact_pi_name:
DUNCAN, MELINDA K
total_cost:
$4,360,371.00
Facility Policies
Services are offerred outside of
Consulting is offerred outside of University of Delaware
Xenium Analyzer offers subcellular profiling of 100s to 1,000s of RNA targets alongside multiplexed protein, in fresh, frozen or FFPE tissue. [Product Link]
Dragonfly spinning disk confocal microscopy system. Andor Dragonfly 600 series high-contrast multi-dimensional imaging platform for live cell imaging. Andor Dragonfly 620 is spinning disk confocal with many advanced modalities capable of widefield imaging, high-sensitivity or high-contrast spinning disk imaging, TIRF (critical angle, Hi-Lo), STORM (single molecule imaging), photostimulation of specific cellular regions and dual-camera recording. [Product Link]
MultiMode 8-HR is an atomic force microscope which is well suited for imaging in both air and fluid. Heating to 250C, cooling to -35C with temperature control accessories. Nanothermal analysis for local polymer phase transition temperatures up to 350C.. Atomic resolution electrochemistry with AFM, STM, and SECPM. Invent your own mode by accessing and modifying any signal, high or low voltage. A large variety of standard operating modes and many capabilities enable the MultiMode 8-HR AFM system to characterize everything from mechanical to electrical properties [Product Link]
FEI Apreo SEM (Scanning Electron Microscope) for Life Sciences
Scanning electron microscope that provides a sub-nanometer or all-around nanometer resolution performance on materials spanning from catalysts, powders, nanoparticles, and bulk magnetic samples to nanodevices. [Product Link]
Transmission electron microscope that is designed for performance and productivity across a wide range of samples and applications, such as 2D and 3D imaging of cells, cell organelles, asbestos, polymers, and soft materials, both at ambient and cryogenic temperatures. [Product Link]
FEI-Tecnai G2 Spirit BioTwin transmission electron microscope
Transmission electron microscope designed for general-purpose, high-resolution imaging of both biological and non-biological samples, offering capabilities like bright-field, dark-field, and diffraction modes, typically utilizing LaB6 electron gun and operating within voltage range of 20-120kV; it's particularly well-suited for analyzing the ultrastructure of delicate specimens with high contrast due to its "BioTwin" features, allowing for low-dose imaging of beam-sensitive samples like cryo-preserved biological materials. [Product Link]
High Pressure Freezing machine from Leica Microsystems to cryo fix biological samples for Electron Microscopy analysis.EM ICE machine allows light and electrical stimulation of samples prior to cryo fixation with millisecond time resolution. [Product Link]
Instrument for cutting specimens at room and low temperature. Used to produce both semi- and ultra-thin sections as well as smooth surfaces of biological samples. [Product Link]
Microscope for imaging beyond the diffraction limit to obtain 2D and 3D nanoscopy results in no time with astounding image quality and resolution, while protecting sample. STED super resolution allows you to study multiple dynamic events simultaneously. [Product Link]
Ultracut E microtome is designed for extremely precise cutting, and achieves consistent high quality ultra thin sections for electron microscopy, or semi-thin sections for light microscopy. It features a continuous feed range from 0 to 2.5,?m and has adjustable cutting speeds of 0.1 to 50 mm/sec. Comes with a control box with power cord, a microtome sectioning unit, and a microscope assembly with AO Stereostar 570 zoom body (0.7X - 4.2X) with attached 10X eyepieces. It has a 6V, 10W halogen illumination system. [Product Link]
Motorized rotary microtome designed to cut extremely thin, uniform slices of paraffin-embedded tissue samples so they can be mounted on glass slides for microscopic examination and disease diagnosis. Offers three sectioning modes (automated, semi-automated, and manual) and features an automatic electronic brake and an anti-static waste tray for enhanced laboratory efficiency. [Product Link]
Critical point dryer with wafer holders that allow automatic anti stiction processing up to 5 pieces of either 100mm, 75mm, 50mm wafers or 10mm square die per process run. All internal surfaces are inert to CO2 and ultra pure alcohols. [Product Link]
Vitrification Robot is fully PC-controlled device for rapid cooling of aqueous samples. System offers semi-automated vitrification to provide fast, easy, and reproducible sample preparation for cryo-EM. Performs cryo-fixation process at constant physical and mechanical conditions like temperature, relative humidity, blotting conditions, and freezing velocity. [Product Link]
Inverted microscope Axio Observer 7 for transmitted light brightfield LED and differential interference contrast. Used for demanding multimodal imaging. [Product Link]
ZEISS Axio Zoom.V16 microscope system includes fluorescence zoom microscope for large fields. Designed for brightfield and fluorescence microscopy of biological samples. Microscope design is optimized for fluorescence microscopy with specific optical components for light management involving specialized filters and dichroic mirrors. [Product Link]
Zeiss LSM 880 with Airyscan Confocal Laser Scanning Microscope
Fully enclosed laser scanning confocal imaging microscopefor heating and environmental control with media perfusion capabilities and CO2 control. It can be used for Live Cell Imaging, FRET and Anisotropy, FRAP and FLIP, FCS, Photoactivation/ -conversion. [Product Link]
Instrument for nanoparticle tracking analysis. A semi-automated method for the characterization of extracellular vesicles with associated analysis software by ParticleMetrix GmbH. [Product Link]
Services include: flow cytometry, cell sorting, cell & tissue culture, immortalization of cell lines, and 2-D DIGE. Additionally, CSC staff offer training and assistance in flow cytometry, tissue culture, and operation of many of our walk up instruments.
This facility provides services outside its institution
This facility provides consulting outside its institution
The Histochemistry and Tissue Processing Core is part of the Department of Biomedical Research, at Nemours. The HTPC is CLIA certified #08D0878042 and provides clinical diagnostic testing for muscle enzyme histochemistry and IHC, as well as routine and complex histology for research. The Core serves internal academic, external academic and corporate clients for the following: routine histology, specialy stanining, enzyme histochemistry, immuno histochemistry (IF and IHC) in-situ, antibody development, imaging and morphometrics (histograms).
This facility provides services outside its institution
This facility provides consulting outside its institution
Last updated:
01/11/2019
Other Facilities at University of Delaware
Bioinformatics Data Science Core FacilityRRID:SCR_017696
Services:
ATAC-Seq+++ChIP-Seq+++Computational - Application Development+++Computational - Bioinformatics+++Computational - High Performance Computing+++Computational - Interactive Compute/storage+++Consultation+++Consultations+++Data Analysis+++Data Analysis And Interpretation+++Data Processing+++Data Processing And Interpretation+++Data Visualization+++DNA Analysis+++Genome/Transcriptome Assembly And Annotation+++Genotyping-by-sequencing+++High Performance Computing+++Metagenomics Analysis+++Metatranscriptomics+++Microbiome+++RNA analysis+++RNA Modification Analysis+++RNAseq+++Web Application Development
Resources:
Bioinformatics
Contact Info:
Dr. Shawn Polson
AP Biopharm Innovation Center/Delaware Biotechnology Institute
The mission of the Bioinformatics Data Science Core Facility is to provide scientific expertise and core infrastructure support in Bioinformatics and Biological Data Science for the Delaware research and education community. Drawing on the combined resources of the Center for Bioinformatics and Computational Biology (CBCB), the Delaware Biotechnology Institute (DBI), the Data Science Institute (DSI), and the Protein Information Resource (PIR), the Core provides both computing infrastructure and knowledgeable personnel with significant hardware, software and professional support for bioinformatics and computational needs. Staff scientists with broad expertise encompassing various areas of bioinformatics, computational biology, and biomedical data sciences provide services, consulting, and research collaborations. BioIT and HPC support is provided by the Computing Systems Manager and IT associates of the Delaware Biotechnology Institute.
This facility provides services outside its institution
This facility provides consulting outside its institution
The University of Delaware Sequencing and Genotyping Center (SGC) supports genomics research through our established expertise with state-of-the-art genomics technologies. Our core center is located in the Delaware Biotechnology Institute, which is an interdisciplinary research unit at the University of Delaware. The SGC provides assistance with experimental design, user training, sample and data analysis. Instrumentation housed in the SGC supports high-throughput, single-molecule, and Sanger sequencing technologies, as well as qualitative and quantitative analysis of nucleic acids.
This facility provides services outside its institution
This facility provides consulting outside its institution
The Flow Cytometry Core Facility, located at the University of Delaware Main campus (UD) in Newark, Delaware, provides a wide variety of flow cytometry and hematology services for internal and external investigators. The Core facility is equipped with –
• Two 15-color FACSAria Fusion high-speed cell sorter,
• BD Rhapsody Express Cell Processing Unit,
• VetScan HM5c veterinary hematology analyzer,
• Nexcelom Cellometer Vision cell counter,
• Zeiss Axiovert 200 inverted fluorescent microscope,
• Thermo Shandon Cytospin 4 & a Beckman Spinchron DLX centrifuge,
• General Laboratory facilities for Mammalian Cell Culture and Sample preparation,
• Laminar flow BSL-2 biosafety cabinets, microscopes and centrifuges.
This facility does not provide services outside its institution
This facility does not consult outside its institution
Last updated:
10/07/2022
CTCR Core Facility at UD
Services:
Cell Imaging+++Cell Sorting+++Clinical Imaging - Small Animal (X-ray, Ultrasound, microCAT, MRI)+++Flow Cytometric Analysis+++Microscopy+++Nucleic Acid Extraction+++Phosphor Imaging+++Real-time qPCR+++Western Blot
The Center for Translational Cancer Research Core Facility is a multi-user facility, with equipment located in Wolf Hall and the Helen F. Graham Cancer Center. Available equipment include an ABI 7000 and 7300 Prism real-time PCR, IVIS Lumina System imager, and BD FACSCalibur, FACSAria II flow cytometers (located at Graham cancer Center) as well an AlphaImager gel documentation system and FluorchemQ chemi-Imager. The facility also has a Glomax Multi-modal plate reader that allows for measuring luminescence, fluorescence and absorbance and several equipment for sample preparation: microcentrifuges, scales, ph meter, spectrophotometer etc. Facilities are available to university researchers, their collaborators and industry on a fee-for-service basis.
This facility provides services outside its institution
This facility provides consulting outside its institution
Last updated:
07/19/2018
Surface Analysis FacilityRRID:SCR_017796
Services:
Assays and Measurements+++Atomic Force Spectroscopy+++Microscopy+++Molecular Imaging+++Spectroscopy
Consulting and services in X-ray Photoelectron Spectroscopy (XPS, also called ESCA), Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS), Atomic Force Microscopy (AFM)
This facility provides services outside its institution
This facility does not consult outside its institution
Last updated:
06/30/2012
Protein Production Core FacilityRRID:SCR_017746
Services:
Protein Extraction/Purification+++SDS-PAGE+++Shared Instrumentation Oversight & Maintenance+++Western Blot
The Protein Production Core (PPC) Facility is a core laboratory that serves academic investigators in Delaware. The PPC is part of shared core facilities supported by the Center of Biomedical Research Excellence (COBRE) in Membrane Protein Production and Characterization at the University of Delaware. The PPC has modern instrumentation for large scale expression, purification and characterization of prokaryotic and eukaryotic proteins for investigators and researchers. The core supports the production of proteins in quantities suitable for structural studies (X-ray and NMR) and functional studies (biological or catalytic). The PPC also has state-of-the-art analytical ultracentrifuge for studying macromolecule interactions.
This facility provides services outside its institution
This facility does not consult outside its institution
