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All Facilities >> University of Notre Dame >> ND Biophysics Instrumentation Core Facility (Biophysics)
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Giselle Jacobson
Last Updated: 05/19/2025
The Biophysics Instrumentation Core (BIC) Facility offers sophisticated instrumentation dedicated to characterizing biomolecular conformations and interactions, as well as equipment for the isolation and purification of macromolecules for subsequent detailed biophysical analysis.
Services are offerred outside of University of Notre Dame
Consulting is offerred outside of University of Notre Dame
Analytical Ultracentrifugation
Data Analysis And Interpretation
Differential Scanning Fluorimetry (DSF)
Isothermal Titration Calorimetry (ITC)
Protein Extraction/Purification
Shared Instrumentation Oversight & Maintenance
Small Molecule Compound Screening
Beckman Coulter ProteomeLab XL-I AUC XL-I
ProteomeLab XL-A/XL-I is a centrifuge with in-solution characterization of proteins, oligomers, aggregates, particles, colloids, and small structures delivers accurate results you can rely on time and again. In-solution characterization allows for testing in native conditions, meaning you determine the sample testing environment that best suits your needs. The column-free separating technique of the ProteomeLab XL-A/XL-I measures the relative change in the distribution of molecular weights, providing an efficient way to measure heterogeneity, stoichiometry and self-associating systems. And, because the measurements are based on the first principles of thermodynamics and hydrodynamics, no standards or calibrations are required. As a result, you spend less time on setup and more time on discovery. Our analytical ultracentrifuge platform offers a variety of customizable options, to meet your needs. Sensitive absorbance optics enable analysis of most samples, and interference optics can be used for low concentrations. Both systems can be implemented simultaneously, to maximize data acquisition in a single run. Additionally, we offer two different rotor configurations, and a variety of cell types, to enable multiple experimental designs. The wide range of rotational velocities also allow investigators to probe protein size, dimerization, and binding constants. [Product Link]
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Bioacore T200 Protein Analysis System
Biacore T200 software offers a range of tools for confident and kinetic analyses. These analyses can be performed using a multicycle approach (many samples against one ligand or when different ligands are immobilized), or alternatively, using singlecycle kinetics (fast runs without regeneration). Biacore T200 is a versatile system for high-quality characterization of molecular interactions, from ions to viruses. One platform for comprehensive characterization of molecular interactions in terms of kinetics, affinity, specificity, comparability, concentration, immunogenicity, and thermodynamics. ligand-binding assays, even for the most complex biologics Confident selection and characterization of the smallest organic compounds to large multidomain proteins Validated software meeting your regulatory expectations by supporting GxP procedures and 21 CFR Part 11 compliance [Product Link]
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General Electric AKTA FPLC System, Protein Purification System
Purification system intended for microgram-scale protein purifications in Tricorn columns up to milligram-scale using HiTrap and HiScreen columns. For fast protein liquid chromatography of tens of grams of protein,can be used with flow rates up to 150 mL/min. This high flow rate is necessary when working with high-flow resins in large columns. Columns can even be packed at flow rates as high as 300 mL/min. System reduces hands-on time so that you can spend less time purifying proteins and more time focusing on your results. Easily switch between different users and applications. To get you up and running quickly, methods are easily created by dragging and dropping predefined templates in UNICORN 7. Purification of protein to sufficiently high yield and purity can be a time- and resource-consuming process. To address fast and efficient protein purification, Can be set up in different ways to handle multistep purification. With an additional column valve up to 10 columns can be connected enabling automation of several samples and steps. [Product Link]
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Jasco J-815 Spectropolarimeter
Circular dichroism (CD) spectroscopy measures differences in the absorption of left-handed polarized light versus right-handed polarized light that arise due to structural asymmetry. The absence of regular structure results in zero CD intensity, while an ordered structure results in a spectrum which can contain both positive and negative signals. [Product Link]
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Life Technologies QuantStudio 3 Real Time PCR System
Applied Biosystems QuantStudio 3 Real-Time PCR System is designed for users who need an , easy-to-use real-time PCR system that doesn't compromise performance and quality. The simplified Design and Analysis software is best for both first-time and experienced users. When connected to the Thermo Fisher Cloud, the QuantStudio 3 system provides access to your data wherever and whenever you want. Using OptiFlex technology (featuring 4 coupled channels and white LED) and featuring three independent Veriflex temperature zones, the QuantStudio 3 system enables improved data accuracy and sensitivity for a broad range of genomic applications. [Product Link]
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https://coremarketplace.org/?FacilityID=1811Institution
Institution ROR ID: https://ror.org/00mkhxb43Keywords:
USEDit, ABRF, biomolecular conformations and interactions, isolation and purification of macromolecules, macromolecules biophysical analysis,
Resource Type:
service resource, access service resource, core facility
Citation:
University of Notre Dame ND Biophysics Instrumentation Core Facility (RRID:SCR_023867)
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10X Genomics Single Cell
10x Genomics Xenium Spatial Transcriptomics
ABI3730XL Sanger Sequencing And Fragment Analysis
Bioinformatics Analysis
BluePippin Automated Size Selection
Custom And Specialty NGS Workflows
High-intensity Acoustic Shearing
Illumina MiSeq Sequencing
Illumina NextSeq Sequencing
Illumina RNA/DNA NGS Library Construction
RNA/DNA Quality Control
Visium HD Spatial Transcriptomics
Melissa Stephens
019 Galvin Life Science
Notre Dame, IN 46556 - United States
RRID:SCR_025555
The Genomics & Bioinformatics Core Facility (GBCF) at Notre Dame serves a diverse research community that spans basic biomedical research in human disease, vector disease research, population genomics, and environmental genomics. Utilizing Illumina sequencing, single-cell analysis, and spatial transcriptome analysis, we offer comprehensive solutions designed to acquire data for a broad range of applications including metagenomics, cancer genomics, microbial genomics, transcriptomics, and epigenomics for both model and non-model systems. Applying robust bioinformatics tools and biocomputing resources, we offer guidance and analysis workflows specifically tailored to your needs.
This facility provides services outside its institution
This facility provides consulting outside its institution
02/11/2025
Mass Spectrometry
RRID:SCR_025596
Core provides analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics.
This facility does not provide services outside its institution
This facility does not consult outside its institution
08/13/2024
Magnetic Resonance
RRID:SCR_025599
Core supports research in chemistry, biochemistry, molecular biology, engineering and related fields. The MRRC operates six solution-state NMR spectrometers (400 to 800 MHz), a solid-state 300 MHz NMR instrument, and an X-band EPR spectrometer. Most instruments are equipped with sample changers for increased sample throughput.
This facility does not provide services outside its institution
This facility does not consult outside its institution
08/13/2024
Transgenics
RRID:SCR_025588
Core develops and uses gene-targeting technology to investigate pathophysiological roles of genes of blood coagulation, anticoagulation, and fibrinolytic pathways in hemostasis, with associated relevance to embryonic development, cancer, infection, and inflammation.
This facility does not provide services outside its institution
This facility does not consult outside its institution
08/13/2024
Animal Facilities (Zebrafish, Fly, Mouse, Vivarium)
RRID:SCR_025552
Home to virtually all laboratory animals. Services include Procurement, Animal care, Breeding, Training,Limited procedures for research.
This facility does not provide services outside its institution
This facility does not consult outside its institution
08/13/2024
2D &
3D Illustration
3D &
4D Image Processing Stations
3D Visualization
Analysis Workstations
Animal Training
Biochemical Analysis
Biological Mechanism
Biological photography/Photomicrography
Body Composition
Cell Imaging
Clinical Imaging - Small Animal (luminescence/fluorescence)
Clinical Imaging - Small Animal (X-ray, Ultrasound, microCAT, MRI)
Computed Tomography (CT)
Computer-assisted Neuron Tracing And Analysis
Confocal Microscope With FCS/FLIM Capabilities
Confocal Microscopy
Confocal/ Super Resolution Microscope
Consultation
Consultations
Correlative Light Electron Microscopy
Cryostat Histology
Customized Protocols
Data Analysis
Data Analysis And Interpretation
Data Processing
Data Processing And Interpretation
Data Visualization
Deconvolution
Drug Discovery
Electron Microscopy
Fluorescence Lifetime
Fluorescence Microscope With Optical Sectioning Capability
Focused Ion Beam (FIB)
Functional Brain Imaging
H&
E Staining
High Content Screening
Histology
Image Aquisition
Image Data Management
Imaging (Cell, Molecular, PET, Translational)
Sarah Chapman
340 McCourtney Hall
Notre Dame, IN 46556 - United States
RRID:SCR_022743
The NDIIF provides an integrated suite of sophisticated microscopes and imaging stations that enable expert users to address the most complex modern research problems and, equally important, expert staff, including technicians and research specialists, to guide the non-expert users. The facility offers imaging expertise in Electron Microscopy, Optical Microscopy, In Vivo Imaging, and Histology.
This facility provides services outside its institution
This facility provides consulting outside its institution
07/14/2023
Assay Development
Assays and Measurements
Immunoassay
Multiplex Fluorescence
Radioimmunoassay
Neal Fedarko
5501 Hopkins Bayview Circle
Room 5A-64 JHAAC
Baltimore, MD 21224 - United States
https://johnshopkins.corefacilities.org/service_center/show_external/3781
RRID:SCR_023212
The Research Laboratory Core is a regional Service Center that performs high throughput assays for the determination of proteins, peptides, hormones and other biochemical markers in support of preclinical and clinical research studies. The laboratory has the equipment and capacity to perform standard immunoassays as well as multiplexed ELISAs. The Research Laboratory Core provides standardized sample handling that upholds high quality control by, for example, minimizing freeze/thaw cycles. The high volume of assays processed in the lab supports reduced investigator cost through batch analysis of samples and direct manufacturer pricing. Quality control is maintained by including manufacturers’ controls as well as low, medium, and high value in-house controls in each assay.
This facility provides services outside its institution
This facility provides consulting outside its institution
01/26/2023
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