The CoreMarketplace: UW Biotechnology Center-Animal Models Core

The Animal Models Core provides support for the generation of novel animal (mice, rats and swine) models using CRISPR or transgenic technology, cryopreservation, rederivation, and IVF recovery of rodent animal models.

Facility Policies

Services are offerred outside of University of Wisconsin–Madison

Consulting is offerred outside of University of Wisconsin–Madison

(To see more facility information, click the in the upper right)

Services offered:

Animal Husbandry

Assisted Reproductive Technologies (Rodent IVF, ICSI)

Biorepository

Bioshipping

Colony Management

CRISPR Injection Services

Embryo Cryopreservation & Recovery Services

ES Cell Electroporation

ES Cell Injection

ES Cell Technology (Mouse)

Fresh/Frozen Sperm IVF

Genome Engineering

Genotyping

Genotyping-by-sequencing

Germplasm

Injection Of DNA Constructs

Rederivation (Mouse)

Sperm Cryopreservation

Tissue Culture

Transgenics

Facility Equipment

No additional equipment has been listed

(To see more facility information, click the in the upper right)

Publications

Publications associated with this facility (Click To View):

1.) English LA, Taylor RJ, Cameron CJ, Broker EA, Dent EW (2024 Oct 25). F-BAR proteins CIP4 and FBP17 function in cortical neuron radial migration and process outgrowth bioRxiv, (), 2024.10.25.620310. . PMCID: 11527352.

2.) Banerjee D, Langberg K, Abbas S, Odermatt E, Yerramothu P, Volaric M, Reidenbach MA, Krentz KJ, Rubinstein CD, Brautigan DL, Abbas T, Gelfand BD, Ambati J, Kerur N (2021 Oct 27). A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling. Nature communications, 12(1), 6207. . ID: 34707113.

3.) Wilson RH, Carney PR, Glover E, Parrott JC, Rojas BL, Moran SM, Yee JS, Nukaya M, Goetz NA, Rubinstein CD, Krentz KJ, Xing Y, Bradfield CA (2021 Apr 12). Generation of an Allelic Series at the Ahr Locus Using an Edited Recombinant Approach. Toxicological sciences : an official journal of the Society of Toxicology, 180(2), 239-251. . ID: 33480436.

4.) Frump AL, Albrecht M, Yakubov B, Breuils-Bonnet S, Nadeau V, Tremblay E, Potus F, Omura J, Cook T, Fisher A, Rodriguez B, Brown RD, Stenmark KR, Rubinstein CD, Krentz K, Tabima DM, Li R, Sun X, Chesler NC, Provencher S, Bonnet S, Lahm T (2021 Mar 15). 17β-Estradiol and estrogen receptor α protect right ventricular function in pulmonary hypertension via BMPR2 and apelin. The Journal of clinical investigation, 131(6), . . ID: 33497359.

5.) Rubinstein CD, McLean DT, Lehman BP, Meudt JJ, Schomberg DT, Krentz KJ, Reichert JL, Meyer MB, Adams M, Konsitzke CM, Shanmuganayagam D (2021). Assessment of Mosaicism and Detection of Cryptic Alleles in CRISPR/Cas9-Engineered Neurofibromatosis Type 1 and TP53 Mutant Porcine Models Reveals Overlooked Challenges in Precision Modeling of Human Diseases. Frontiers in genetics, 12(), 721045. . ID: 34630515.

6.) Fu A, Koth ML, Brown RM, Shaw SA, Wang L, Krentz KJ, Zhang X, Hui CC, Jorgensen JS (2020 Aug 21). IRX3 and IRX5 collaborate during ovary development and follicle formation to establish responsive granulosa cells in the adult mouse†. Biology of reproduction, 103(3), 620-629. . ID: 32507881.

7.) Pantera H, Hu B, Moiseev D, Dunham C, Rashid J, Moran JJ, Krentz K, Rubinstein CD, Won S, Li J, Svaren J (2020 Jun 27). Pmp22 super-enhancer deletion causes tomacula formation and conduction block in peripheral nerves. Human molecular genetics, 29(10), 1689-1699. . ID: 32356557.

8.) Barnett BR, Torres-Velázquez M, Yi SY, Rowley PA, Sawin EA, Rubinstein CD, Krentz K, Anderson JM, Bakshi VP, Yu JJ (2019 Feb 11). Sex-specific deficits in neurite density and white matter integrity are associated with targeted disruption of exon 2 of the Disc1 gene in the rat. Translational psychiatry, 9(1), 82. . ID: 30745562.

9.) Fu A, Oberholtzer SM, Bagheri-Fam S, Rastetter RH, Holdreith C, Caceres VL, John SV, Shaw SA, Krentz KJ, Zhang X, Hui CC, Wilhelm D, Jorgensen JS (2018 Aug). Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries. PLoS genetics, 14(8), e1007488. . ID: 30071018.

10.) Baan M, Krentz KJ, Fontaine DA, Davis DB (2016 Dec). Successful in vitro fertilization and generation of transgenics in Black and Tan Brachyury (BTBR) mice. Transgenic research, 25(6), 847-854. . ID: 27515175.

11.) Lee WH, Higuchi H, Ikeda S, Macke EL, Takimoto T, Pattnaik BR, Liu C, Chu LF, Siepka SM, Krentz KJ, Rubinstein CD, Kalejta RF, Thomson JA, Mullins RF, Takahashi JS, Pinto LH, Ikeda A (2016 Nov 15). Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. eLife, 5(), . . ID: 27863209.

12.) Liu Y, Johnson BP, Shen AL, Wallisser JA, Krentz KJ, Moran SM, Sullivan R, Glover E, Parlow AF, Drinkwater NR, Schuler LA, Bradfield CA (2014 Sep 30). Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice. Proceedings of the National Academy of Sciences of the United States of America, 111(39), 14295-300. . ID: 25225411.

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Associations

Cancer Center

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Metadata

Links

All the links listed resolve to this core profile

https://coremarketplace.org/?FacilityID=2588
https://coremarketplace.org/RRID:SCR_024797

Institution

Institution ROR ID: https://ror.org/01y2jtd41

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

ABRF, generation of novel animals, mice models, rats models, swine models, CRISPR, transgenic technology, cryopreservation, rederivation, IVF recovery,

Resource Type:

core facility, access service resource, service resource

Citation:

University of Wisconsin Madison Biotechnology Center Animal Models Core Facility (RRID:SCR_024797)

UW Biotechnology Center-Animal Models Core (Transgenics)

Primary Contact:

Facility RRID

Facility Details

Facility Policies

(To see more facility information, click the in the upper right)

Services offered:

Facility Equipment

(To see more facility information, click the in the upper right)

Publications

(To see more facility information, click the in the upper right)

Associations

Cancer Center

(To see more facility information, click the in the upper right)

Metadata

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Facility Profile QR Code (links to this profile)

(To see more facility information, click the in the upper right)

Contact Kathy Krentz

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UW Biotechnology Center-Animal Models Core

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