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All Facilities >> University of North Carolina at Chapel Hill >> UNC Neuroscience Microscopy Core (Microscopy (Electron, Fluorescence, Optical))

UNC Neuroscience Microscopy Core (Microscopy (Electron, Fluorescence, Optical))

Facility Details

About This Facility

Services and Equipment

Publications

Associations

Metadata

University of North Carolina at Chapel Hill

5114 Mary Ellen Jones Building

116 Manning Drive, Campus Box 7250

Chapel Hill, NC 27599

United States of America

(919) 966-5807

https://www.med.unc.edu/neuroscience/core-facilities/neuro-microscopy/

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Quicklinks:

https://coremarketplace.org/uncnmc https://coremarketplace.org/RRID:SCR_019060

Facility LIMS Page

https://uncch.ilab.agilent.com/service_center/4868/?tab=about

Primary Contact:

Michelle Itano

(919) 966-5807

Last Updated: 09/30/2020

Facility RRID

RRID:SCR_019060

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Facility Grant Number

P30 NS045892, U54 HD079124

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Facility Details

The UNC Neuroscience Microscopy Core is a center for high-resolution imaging and aims to make this technology accessible to neuroscientists and other scientific researchers.

Goals of the UNC Neuroscience Microscopy Core:

To provide a full spectrum of advanced systems for cellular and molecular imaging of in vitro and in vivo samples.
To implement new imaging technologies, particularly related to real time and tissue clearing based imaging of neurodevelopment and neural functions.
To offer training, consultation, data analysis, image processing, and centralized technical expertise to support the imaging needs of neuroscientists and other researchers.
We are supported, in part, by funding from the NIH-NINDS Neuroscience Center Support Grant P30 NS045892 and the NIH-NICHD Intellectual and Developmental Disabilities Research Center Support Grant U54 HD079124.

Facility Policies

Services are offerred outside of University of North Carolina at Chapel Hill

Consulting is offerred outside of University of North Carolina at Chapel Hill

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Services offered:

3D Visualization

Cell Imaging

Computational - High Performance Computing

Confocal Microscopy

Consultations

Data Analysis

Data Processing And Interpretation

High Content Screening

High-throughput Screening

Histology

Image Processing And Analysis

Immunohistochemistry

Microscopy

Molecular Imaging

Multiphoton Microscopy

Facility Equipment

Olympus MVX10 Macroview Stereo Fluorescence Microscope

Stereo fluorescence microscope that has single zoom optical path for fluorescent observation or cellular level observation. It has pupil division mechanism to mimic stereo microscopes. [Product Link]

RRID: SCR_018612

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Zeiss LSM 710 Confocal Inverted Microscope

LSM 710 is a confocal is an inverted microscope that enables confocal microscopy for a wide variety of applications. You work with up to ten dyes and use continuous spectral detection across the complete wavelength range. With the inverse Axio Observer from Carl Zeiss, LSM 710 offers you unrivalled confocal microscopy in cell and developmental biology. Upright stands such as Axio Imager or Axio Examiner offer you have all the equipment you need to record neurobiological, physiological and developmental relationships to an exceptional standard. [Product Link]

RRID:SCR_018063

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Zeiss LSM 780
Nikon Eclipse Ti2
Olympus FV3000RS
Zeiss LSM 7MP
Windows Data Analysis Workstation
iRODS Linux Workstation

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Publications

Publications associated with this facility (Click To View):

1.) Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon KH 3rd, Kato T, Lee RE, Yount BL, Mascenik TM, Chen G, Olivier KN, Ghio A, Tse LV, Leist SR, Gralinski LE, Schäfer A, Dang H, Gilmore R, Nakano S, Sun L, Fulcher ML, Livraghi-Butrico A, Nicely NI, Cameron M, Cameron C, Kelvin DJ, de Silva A, Margolis DM, Markmann A, Bartelt L, Zumwalt R, Martinez FJ, Salvatore SP, Borczuk A, Tata PR, Sontake V, Kimple A, Jaspers I, O (2020 Jul 23). SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract. Cell, 182(2), 429-446.e14. . PMID: 32526206.

2.) Huang Q, Cohen MA, Alsina FC, Devlin G, Garrett A, McKey J, Havlik P, Rakhilin N, Wang E, Xiang K, Mathews P, Wang L, Bock C, Ruthig V, Wang Y, Negrete M, Wong CW, Murthy PKL, Zhang S, Daniel AR, Kirsch DG, Kang Y, Capel B, Asokan A, Silver DL, Jaenisch R, Shen X (2020 Apr 10). Intravital imaging of mouse embryos. Science (New York, N.Y.), 368(6487), 181-186. . PMID: 32273467.

3.) Bartsch VB, Niehaus JK, Taylor-Blake B, Zylka MJ (2019). Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice. PloS one, 14(6), e0217819. doi: 10.1371/journal.pone.0217819. PMID: 31167004.

4.) Loo L, Simon JM, Xing L, McCoy ES, Niehaus JK, Guo J, Anton ES, Zylka MJ (2019 Jan 11). Single-cell transcriptomic analysis of mouse neocortical development. Nature communications, 10(1), 134. doi: 10.1038/s41467-018-08079-9. PMID: 30635555.

5.) Lorenzo DN, Badea A, Zhou R, Mohler PJ, Zhuang X, Bennett V (2019 Jul 30). βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport. Proceedings of the National Academy of Sciences of the United States of America, 116(31), 15686-15695. . PMID: 31209033.

6.) Ocasio J, Babcock B, Malawsky D, Weir SJ, Loo L, Simon JM, Zylka MJ, Hwang D, Dismuke T, Sokolsky M, Rosen EP, Vibhakar R, Zhang J, Saulnier O, Vladoiu M, El-Hamamy I, Stein LD, Taylor MD, Smith KS, Northcott PA, Colaneri A, Wilhelmsen K, Gershon TR (2019 Dec 20). scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy. Nature communications, 10(1), 5829. doi: 10.1038/s41467-019-13657-6. PMID: 31863004.

7.) Rossi MA, Basiri ML, McHenry JA, Kosyk O, Otis JM, van den Munkhof HE, Bryois J, Hübel C, Breen G, Guo W, Bulik CM, Sullivan PF, Stuber GD (2019 Jun 28). Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding. Science (New York, N.Y.), 364(6447), 1271-1274. . PMID: 31249056.

8.) Yang R, Walder-Christensen KK, Kim N, Wu D, Lorenzo DN, Badea A, Jiang YH, Yin HH, Wetsel WC, Bennett V (2019 Jul 23). ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity. Proceedings of the National Academy of Sciences of the United States of America, 116(30), 15262-15271. . PMID: 31285321.

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Associations

ABRF

Association of Biomolecular Resource Facilities

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Metadata

Links

All the links listed resolve to this core listing

https://coremarketplace.org/?FacilityID=1052
https://coremarketplace.org/uncnmc
https://coremarketplace.org/RRID:SCR_019060

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Keywords:

USEDit, microscopy, high resolution imaging, neuroscience microscopy, cellular imaging, molecular imaging, in vitro imaging, in vivo imaging, neurodevelopment, neural function, data analysis, image processing

Resource Type:

Resource, service resource, training service resource, core facility, access service resource, data or information resource

Citation:

University of North Carolina at Chapel Hill School of Medicine Neuroscience Microscopy Core Facility (RRID:SCR_019060)

UNC Neuroscience Microscopy Core (Microscopy (Electron, Fluorescence, Optical))

Quicklinks:

Facility LIMS Page

Primary Contact:

Facility RRID

Facility Grant Number

Facility Details

Facility Policies

(To see more facility information, click the in the upper right)

Services offered:

Facility Equipment

(To see more facility information, click the in the upper right)

Publications

(To see more facility information, click the in the upper right)

Associations

ABRF

(To see more facility information, click the in the upper right)

Metadata

SciCrunch Data Imports (data maintained by https://scicrunch.org)

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UNC Neuroscience Microscopy Core (Microscopy (Electron, Fluorescence, Optical))

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