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All Facilities >> Medical University of South Carolina >> MUSC Gnotobiotic Animal Core (Animal Facilities (Zebrafish, Fly, Mouse, Vivarium))

MUSC Gnotobiotic Animal Core (Animal Facilities (Zebrafish, Fly, Mouse, Vivarium))

Facility Details

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Services and Equipment

Publications

Associations

Metadata

Medical University of South Carolina

173 Ashley Avenue

MSC 507

Charleston, SC 29425

United States of America

https://dentistry.musc.edu/research/gcohr

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Quicklinks:

https://coremarketplace.org/RRID:SCR_018884

Primary Contact:

Caroline Westwater

Last Updated: 08/04/2020

Facility RRID

RRID:SCR_018884

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Facility Details

The Medical University of South Carolina (MUSC) Gnotobiotic Animal Core offers investigators a unique opportunity to address research questions that require the use of gnotobiotic animals (germfree and defined flora mice). Facility services are available to scientists at academic institutions, biotechnology companies, and large pharmaceutical corporations.

As a cost center, all services provided by the MUSC Gnotobiotic Animal Core are on a fee-for-service basis. Please contact the Core Director to inquire about services and current rates.

Facility Policies

Services are offerred outside of Medical University of South Carolina

Consulting is offerred outside of Medical University of South Carolina

(To see more facility information, click the in the upper right)

Services offered:

Animal Husbandry

Customized Protocols

Defined-flora Mice

Gnotobiotic Mice

Microbiological Culturing

Provide Germfree Mice

Veterinary Services

Facility Equipment

No equipment has been listed

(To see more facility information, click the in the upper right)

Publications

Publications associated with this facility (Click To View):

1.) Hathaway-Schrader JD, Poulides NA, Carson MD, Kirkpatrick JE, Warner AJ, Swanson BA, Taylor EV, Chew ME, Reddy SV, Liu B, Westwater C, Novince CM (2020 Mar). Specific Commensal Bacterium Critically Regulates Gut Microbiota Osteoimmunomodulatory Actions During Normal Postpubertal Skeletal Growth and Maturation. PMID: 32161843.

2.) Wu YY, Westwater C, Xiao E, Dias Corrêa J, Xiao WM, Graves DT (2018 Feb). Establishment of oral bacterial communities in germ-free mice and the influence of recipient age. PMID: 28776953.

3.) Novince CM, Whittow CR, Aartun JD, Hathaway JD, Poulides N, Chavez MB, Steinkamp HM, Kirkwood KA, Huang E, Westwater C, Kirkwood KL (2017 Jul 18). Commensal Gut Microbiota Immunomodulatory Actions in Bone Marrow and Liver have Catabolic Effects on Skeletal Homeostasis in Health. PMID: 28720797.

4.) Yu DH, Gadkari M, Zhou Q, Yu S, Gao N, Guan Y, Schady D, Roshan TN, Chen MH, Laritsky E, Ge Z, Wang H, Chen R, Westwater C, Bry L, Waterland RA, Moriarty C, Hwang C, Swennes AG, Moore SR, Shen L (2015 Sep 30). Postnatal epigenetic regulation of intestinal stem cells requires DNA methylation and is guided by the microbiome. PMID: 26420038.

5.) Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA, Miyamoto Y, Eckmann L, Dhungana S, Pathmasiri W, Sumner S, Westwater C, Brenner DA, Schnabl B (2015 Mar). Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. PMID: 25466902.

6.) Westwater C, Schofield DA (2012). Laser capture microdissection of Candida albicans from host tissue. PMID: 22328390.

7.) Westwater C, Schofield DA, Nicholas PJ, Paulling EE, Balish E (2007 Oct). Candida glabrata and Candida albicans; dissimilar tissue tropism and infectivity in a gnotobiotic model of mucosal candidiasis. PMID: 17854475.

8.) Westwater C, Balish E, Warner TF, Nicholas PJ, Paulling EE, Schofield DA (2007 Sep). Susceptibility of gnotobiotic transgenic mice (Tgepsilon26) with combined deficiencies in natural killer cells and T cells to wild-type and hyphal signalling-defective mutants of Candida albicans. PMID: 17761474.

9.) Fugle CW, Zhang Y, Hong F, Sun S, Westwater C, Rachidi S, Yu H, Garret-Mayer E, Kirkwood K, Liu B, Li Z (2016). CD24 blunts oral squamous cancer development and dampens the functional expansion of myeloid-derived suppressor cells. PMID: 27853649.

10.) Balish E (2009 Mar). A URA3 null mutant of Candida albicans (CAI-4) causes oro-oesophageal and gastric candidiasis and is lethal for gnotobiotic, transgenic mice (Tgepsilon26) that are deficient in both natural killer and T cells. PMID: 19208876.

11.) Schofield DA, Westwater C, Paulling EE, Nicholas PJ, Balish E (2003 Feb). Detection of Candida albicans mRNA from formalin-fixed, paraffin-embedded mouse tissues by nested reverse transcription-PCR. PMID: 12574294.

12.) Schofield DA, Westwater C, Warner T, Nicholas PJ, Paulling EE, Balish E (2003 Aug 15). Hydrolytic gene expression during oroesophageal and gastric candidiasis in immunocompetent and immunodeficient gnotobiotic mice. PMID: 12898449.

13.) Schofield DA, Westwater C, Balish E (2004 Oct 1). beta-defensin expression in immunocompetent and immunodeficient germ-free and Candida albicans-monoassociated mice. PMID: 15346345.

14.) Dolan JW, Bell AC, Hube B, Schaller M, Warner TF, Balish E (2004 Oct). Candida albicans PLD I activity is required for full virulence. PMID: 15552646.

15.) Schofield DA, Westwater C, Balish E (2005 Jan). Divergent chemokine, cytokine and beta-defensin responses to gastric candidiasis in immunocompetent C57BL/6 and BALB/c mice. PMID: 15591261.

16.) Balish E, Warner TF, Nicholas PJ, Paulling EE, Westwater C, Schofield DA (2005 Mar). Susceptibility of germfree phagocyte oxidase- and nitric oxide synthase 2-deficient mice, defective in the production of reactive metabolites of both oxygen and nitrogen, to mucosal and systemic candidiasis of endogenous origin. PMID: 15731028.

17.) Schofield DA, Westwater C, Warner T, Balish E (2005 Mar 15). Differential Candida albicans lipase gene expression during alimentary tract colonization and infection. PMID: 15766791.

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Associations

COBRE

Centers of Biomedical Research Excellence

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Metadata

Links

All the links listed resolve to this core listing

https://coremarketplace.org/?FacilityID=889
https://coremarketplace.org/RRID:SCR_018884

SciCrunch Data Imports (data maintained by https://scicrunch.org)

Keywords:

USEDit, gnotobiotic animals, germ free mice, defined flora mice, service, tissue collection, breeding newly derived germ free mice

Resource Type:

Resource, service resource, core facility, access service resource

Citation:

Medical University of South Carolina College of Dental Medicine Gnotobiotic Animal Core Facility (RRID:SCR_018884)

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MUSC Gnotobiotic Animal Core (Animal Facilities (Zebrafish, Fly, Mouse, Vivarium))

Facility Details

About This Facility

Services and Equipment

Publications

Associations

Metadata

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