University of Texas Southwestern Medical Center
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8813United States of Americahttps://www.utsouthwestern.edu/education/medical-school/departments/neurology/research/microscopy-facility/
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Last Updated: 06/28/2022
The Whole Brain Microscopy Facility (WBMF) in the UT Southwestern Department of Neurology was established in 2014 and is supported by the Texas Institute for Brain Injury and Repair (TIBIR). The facility is particularly well-suited to advance the study of traumatic brain injury as well as other neurological and psychiatric disorders by utilizing cutting-edge microscopy strategies to evaluate neuropathology across micro-, meso-, and macro-scales of inquiry. These techniques enable the tracing of neuronal projections from injured sites to their long-range targets, allowing crucial and previously unfeasible studies into the altered connections established by neurons following brain injury.
We provide access to several high-throughput microscopes for UT Southwestern and external researchers. WBMF houses two TissueVision TissueCyte 1000 instruments for the purpose of generating high-resolution, 3D renderings of entire rodent brains as well as two slide scanning microscopes (Hamamatsu Nanozoomer and Zeiss Axioscan.Z1) for the purpose of creating digital images of whole slides. We have dedicated computational science staff to perform automated quantitative image analysis at the whole brain or whole slide level. We also offer cryosectioning, general histological staining such as H&E, cresyl violet, or Luxol Fast Blue, and immunostaining.
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