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All Facilities >> University of Texas Southwestern Medical Center >> UTSW - Whole Brain Microscopy Facility (Microscopy (Electron, Fluorescence, Optical))
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University of Texas Southwestern Medical Center
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8813
United States of Americahttps://www.utsouthwestern.edu/education/medical-school/departments/neurology/research/microscopy-facility/Denise Ramirez
Last Updated: 07/20/2020
The Whole Brain Microscopy Facility (WBMF) in the UT Southwestern Department of Neurology and Neurotherapeutics was established in 2014 and is supported by the Texas Institute for Brain Injury and Repair (TIBIR). The facility is particularly well-suited to advance the study of traumatic brain injury as well as other neurological and psychiatric disorders by utilizing cutting-edge microscopy strategies to evaluate neuropathology across micro-, meso-, and macro-scales of inquiry. These techniques enable the tracing of neuronal projections from injured sites to their long-range targets, allowing crucial and previously unfeasible studies into the altered connections established by neurons following brain injury.
We provide access to several high-throughput microscopes for UT Southwestern and external researchers. WBMF houses two TissueVision TissueCyte 1000 instruments for the purpose of generating high-resolution, 3D renderings of entire rodent brains as well as two slide scanning microscopes (Hamamatsu Nanozoomer and Zeiss Axioscan.Z1) for the purpose of creating digital images of whole slides. We also offer cryosectioning, general histological staining such as H&E, cresyl violet, or Luxol Fast Blue, and immunostaining.
Services are offerred outside of University of Texas Southwestern Medical Center
Consulting is offerred outside of University of Texas Southwestern Medical Center
Computational - High Performance Computing
Data Processing And Interpretation
TissueVision TissueCyte 1000 Photon Imaging System
Whole organ serial two photon tomography imaging platform that allows imaging of whole fixed organs based on high speed two photon microscopy TPM and integrated tissue sectioning. [Product Link]
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Leica CM1950 Cryostat
The Leica CM1950 is a highly adaptable cryostat platform that can be tailor-made for each laboratory. By starting with the standard instrument and choosing from a range of options, every laboratory can have a clinical cryostat for their individual needs. Innovation and human-oriented features provide a cryostat with a new level of performance. The CM1950 is a high-performance cryostat with an encapsulated microtome and separate specimen cooling. It features a UV disinfection system, an (optional) integrated extraction system for section waste and an (optional) motor for motorized sectioning. The cryostat is designed to produce frozen sections for biological, medical and industrial applications. The CM1950 is suitable for in-vitro diagnostic (IVD) applications. [Product Link]
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Zeiss Axioscan.Z1
Hamamatsu Nanozoomer
Leica fluorescence stereomicroscope
Leica sliding microtome
MBF Bioscience Neurolucida 360
MBF Bioscience StereoInvestigator
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https://coremarketplace.org/?FacilityID=975Keywords:
Traumatic, brain, injury, neurological, psychiatric, disorder, microscopy, evaluate, neuropathy, stereological, analysis, neuron, tracing, 3D, rendering, dataset, service, core
Resource Type:
Resource, service resource, core facility, access service resource
Citation:
Texas University Southwestern Medical Center Whole Brain Microscopy Core Facility (RRID:SCR_017949)
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Facility Details
About This Facility
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