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All Facilities >> University of Notre Dame >> NDIIF- Notre Dame Integrated Imaging Facility (Imaging (Cell, Molecular, PET, Translational))
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Sarah Chapman
Last Updated: 05/19/2025
The NDIIF provides an integrated suite of sophisticated microscopes and imaging stations that enable expert users to address the most complex modern research problems and, equally important, expert staff, including technicians and research specialists, to guide the non-expert users. The facility offers imaging expertise in Electron Microscopy, Optical Microscopy, In Vivo Imaging, and Histology.
Services are offerred outside of University of Notre Dame
Consulting is offerred outside of University of Notre Dame
3D & 4D Image Processing Stations
Biological photography/Photomicrography
Clinical Imaging - Small Animal (luminescence/fluorescence)
Clinical Imaging - Small Animal (X-ray, Ultrasound, microCAT, MRI)
Computer-assisted Neuron Tracing And Analysis
Confocal Microscope With FCS/FLIM Capabilities
Confocal/ Super Resolution Microscope
Correlative Light Electron Microscopy
Data Analysis And Interpretation
Data Processing And Interpretation
Fluorescence Microscope With Optical Sectioning Capability
Magnetic Resonance Imaging (MRI)
Multiphoton/ Harmonic Generation Microscope
Positron Emission Tomography (PET)
Processing & Embedding- Histology
Shared Instrumentation Oversight & Maintenance
Spinning Disk Confocal Imaging
FEI Talos F200i TEM and STEM
Microscope that is designed for performance and productivity across a wide range of Materials Science samples and applications. Its standard X-Twin pole piece gap combined with a reproducibly performing electron column opens opportunities for high-resolution 2D and 3D characterization, in situ dynamic observations, and diffraction applications. [Product Link]
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Leica CM1950 Cryostat
The Leica CM1950 is a highly adaptable cryostat platform that can be tailor-made for each laboratory. By starting with the standard instrument and choosing from a range of options, every laboratory can have a clinical cryostat for their individual needs. Innovation and human-oriented features provide a cryostat with a new level of performance. The CM1950 is a high-performance cryostat with an encapsulated microtome and separate specimen cooling. It features a UV disinfection system, an (optional) integrated extraction system for section waste and an (optional) motor for motorized sectioning. The cryostat is designed to produce frozen sections for biological, medical and industrial applications. The CM1950 is suitable for in-vitro diagnostic (IVD) applications. [Product Link]
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Nikon A1R MP Confocal Microscope
Nikon A1R MP is a multiphoton imaging system featuring a high resolution galvanometer scanner and a high speed resonant scanner that is capable of frame rates from 30 fps at 512 x 512 pixels to as fast as 420 fps in band scan mode. New 4 channel non-descanned detectors with higher sensitivity, reduced dark current and broad spectral range allow for real time unmixing of closely spaced probes for accurate and high-contrast spectral imaging. This is especially important in multiphoton microscopy because of the overlap of emission spectra of probes and autofluorescence, which is often unavoidable when using a single laser line. [Product Link]
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Nikon AZ100 Confocal Microscope
Multi purpose confocal zoom microscope system that covers range of magnifications from 5x to 400x. It has triple nosepiece that can switch magnifications. [Product Link]
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-Magellan 400 FESEM
-Helios G4 Ux Dual Beam Electron Microscope
-Spectra 30-300 (S)TEM
-JEOL 2011 TEM
-Leica EM UC7 Ultramicrotome with FC7 Cryo Chamber
-Leica Automatic Plunge Freezer EM GP2
-Nikon Eclipse 90i Widefield Fluorescent Microscope
-Nikon C2+ Laser Scanning Confocal Microscope
-Bruker Luxendo MuVi SPIM Light Sheet
-Nikon CSU-X1 Spinning Disk System
-Leica Stellaris 8 DIVE
-Keyence BZ-X810
-IMARIS Analysis Software
-Albira (PET/SPECT/CT)
-Perkin Elmer IVIS Lumina
-Bruker ICON MRI (1T)
-MARS Medipix Spectral X-ray CT
-Advanced Molecular Imaging HT Spectral Instrument
-EchoMRI (body composition analysis)
-Scanco VivaCT80 Micro X-ray CT
-Leica TP 1020 Tissue Processor
-Leica HistoCore Autocut Automated Rotary microtome
-Leica HistoCore Arcadia H
-Leica VT 2100S Vibratome
-Leica CryoJane Tape Transfer System
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https://coremarketplace.org/?FacilityID=1072Institution
Institution ROR ID: https://ror.org/00mkhxb43Keywords:
USEDit, ABRF, microscopes and imaging stations, Electron Microscopy, Optical Microscopy, In Vivo Imaging, Histology
Resource Type:
service resource, access service resource, core facility
Citation:
University of Notre Dame Integrated Imaging Core Facility (RRID:SCR_022743)
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10X Genomics Single Cell
10x Genomics Xenium Spatial Transcriptomics
ABI3730XL Sanger Sequencing And Fragment Analysis
Bioinformatics Analysis
BluePippin Automated Size Selection
Custom And Specialty NGS Workflows
High-intensity Acoustic Shearing
Illumina MiSeq Sequencing
Illumina NextSeq Sequencing
Illumina RNA/DNA NGS Library Construction
RNA/DNA Quality Control
Visium HD Spatial Transcriptomics
Melissa Stephens
019 Galvin Life Science
Notre Dame, IN 46556 - United States
RRID:SCR_025555
The Genomics & Bioinformatics Core Facility (GBCF) at Notre Dame serves a diverse research community that spans basic biomedical research in human disease, vector disease research, population genomics, and environmental genomics. Utilizing Illumina sequencing, single-cell analysis, and spatial transcriptome analysis, we offer comprehensive solutions designed to acquire data for a broad range of applications including metagenomics, cancer genomics, microbial genomics, transcriptomics, and epigenomics for both model and non-model systems. Applying robust bioinformatics tools and biocomputing resources, we offer guidance and analysis workflows specifically tailored to your needs.
This facility provides services outside its institution
This facility provides consulting outside its institution
02/11/2025
Mass Spectrometry
RRID:SCR_025596
Core provides analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics.
This facility does not provide services outside its institution
This facility does not consult outside its institution
08/13/2024
Magnetic Resonance
RRID:SCR_025599
Core supports research in chemistry, biochemistry, molecular biology, engineering and related fields. The MRRC operates six solution-state NMR spectrometers (400 to 800 MHz), a solid-state 300 MHz NMR instrument, and an X-band EPR spectrometer. Most instruments are equipped with sample changers for increased sample throughput.
This facility does not provide services outside its institution
This facility does not consult outside its institution
08/13/2024
Transgenics
RRID:SCR_025588
Core develops and uses gene-targeting technology to investigate pathophysiological roles of genes of blood coagulation, anticoagulation, and fibrinolytic pathways in hemostasis, with associated relevance to embryonic development, cancer, infection, and inflammation.
This facility does not provide services outside its institution
This facility does not consult outside its institution
08/13/2024
Animal Facilities (Zebrafish, Fly, Mouse, Vivarium)
RRID:SCR_025552
Home to virtually all laboratory animals. Services include Procurement, Animal care, Breeding, Training,Limited procedures for research.
This facility does not provide services outside its institution
This facility does not consult outside its institution
08/13/2024
Analytical Ultracentrifugation
Antibody Characterization
Automated Liquid Handling
Biological Mechanism
Bioluminsecence Imaging
Circular Dichroism (CD)
Consultation
Crystal Optimization
Data Analysis And Interpretation
Differential Scanning Fluorimetry (DSF)
DNA Analysis
Drug Discovery
Experimental Design
Fragment-based Drug Discovery
Fragment-based Screening
High-throughput Screening
Image Aquisition
Image Processing And Analysis
Isothermal Titration Calorimetry (ITC)
Molecular Imaging
Monoclonal Antibody
Phosphor Imaging
Protein Crystallization
Protein Extraction/Purification
Protein Production
Protocol Development
Real-time qPCR
RNA analysis
Sample Preparation
Shared Instrumentation Oversight & Maintenance
Small Molecule Compound Screening
Spectroscopy
Structural Biology
Surface Plasmon Resonance (SPR)
Thermal Analysis
Training
X-Ray Crystallography
Biophysics
Giselle Jacobson
446C Stepan Chemistry Hall
Notre Dame, IN 46556 - United States
RRID:SCR_023867
The Biophysics Instrumentation Core (BIC) Facility offers sophisticated instrumentation dedicated to characterizing biomolecular conformations and interactions, as well as equipment for the isolation and purification of macromolecules for subsequent detailed biophysical analysis.
This facility provides services outside its institution
This facility provides consulting outside its institution
07/24/2023
Assay Development
Assays and Measurements
Immunoassay
Multiplex Fluorescence
Radioimmunoassay
Neal Fedarko
5501 Hopkins Bayview Circle
Room 5A-64 JHAAC
Baltimore, MD 21224 - United States
https://johnshopkins.corefacilities.org/service_center/show_external/3781
RRID:SCR_023212
The Research Laboratory Core is a regional Service Center that performs high throughput assays for the determination of proteins, peptides, hormones and other biochemical markers in support of preclinical and clinical research studies. The laboratory has the equipment and capacity to perform standard immunoassays as well as multiplexed ELISAs. The Research Laboratory Core provides standardized sample handling that upholds high quality control by, for example, minimizing freeze/thaw cycles. The high volume of assays processed in the lab supports reduced investigator cost through batch analysis of samples and direct manufacturer pricing. Quality control is maintained by including manufacturers’ controls as well as low, medium, and high value in-house controls in each assay.
This facility provides services outside its institution
This facility provides consulting outside its institution
01/26/2023
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