Core includes two full-service microscopy facilities available to researchers, clinical partners and industry members with the instruments and resources for a range of bioimaging services as well as analysis of non-biological materials. The ALMC has two locations; one within Biodesign (Biodesign Imaging Facility: BIF) and the other located in the School of Life Sciences (Regenerative Medicine Imaging Facility: RMIF). Both locations offer the technology, instrumentation and expertise to meet critical research needs in optical microscopy. These tools enable the observation of subcellular structures, track signaling pathways, and measure molecular interactions in live or fixed biological samples. Both locations are configured to accommodate live cell imaging and are BSL-2 certified with available cell culture facilities to maintain and prep samples. In both locations there is a dedicated image analysis workstation with software that includes deconvolution, particle tracking, colocalization, 3D measurements, extended depth of field and other analytic and image processing modules.

Facility provides comprehensive electronics fabrication and packaging capabilities bridging the high risk, resource-intensive gap between innovation and product development in an information-secure environment. AEP offers backplane electronics design, device fabrication, fanout wafer level packaging, electrical device test and integration capabilities, and operates dedicated pilot line toolsets for technology development. Assists with thin film processing, thin film characterization, device packaging and characterization, photolithography, etching, and flexible electronics. AEP is capable of processing 2 wafers all the way up to 300 mm round wafers.Services include microelectronic device prototyping and packaging, wafer coating or cleaning, wafer metrology, and pilot scale product demonstration. AEP is equipped with the tools and expertise to help take your electronic device from prototype fabrication to final packaging.

Core is dedicated to advancing biomedical discovery through modern and highly advanced imaging technologies. Provides access to high-resolution, non- and minimally invasive imaging tools that enable visualization of biological processes in vivo. Core offers imaging services including MR Solutions Multi-Field MRI systems (3T, 7T, and 9.4T) for detailed anatomical and functional imaging, the IVIS Lumina S5 platform for sensitive bioluminescence and fluorescence imaging, and the TriTom Photoacoustic Imager for high-contrast 3D photoacoustic visualization and multi-spectral imaging of molecular and vascular dynamics.Facility supports a wide range of preclinical applications. These include longitudinal animal studies, drug development, biomarker discovery, and validation of novel imaging agents.

Sequencing facility offers to perform a full range of genomic applications, such as Whole Genome Sequencing (WGS), RNA sequencing (including options for poly(A) selection, ribosomal depletion, and degraded/FFPE RNA), library preparation of ChIP samples, de novo sequencing, metagenomics sequencing, single-cell sequencing and PacBio long read sequencing applications.All next generation sequencing applications are performed on the Illumina platform with the NextSeq and NovaSeq instruments. Long-read sequencing applications are performed on the PacBio Revio using Single-Molecule, Real-Time (SMRT) Sequencing. The Revio is ideal for high-quality de novo whole genome assemblies, full-length transcriptomes, cell-type specific isoforms, and targeted long-read amplicon sequencing. Provides 10X genomics instrument for sample partitioning and molecular barcoding prior to sequencing. For metagenomics sequencing, 16S, 18S, or ITS regions can be isolated and sequenced as relevant and are sequenced on the NextSeq instrument, allowing researchers to characterize and study microbial communities from various environments such as soils, freshwater, seawater, wastewater, and host-microbe associations.Offers expertise of facility staff is available for researchers at any point in the experimental process.

Core offers solar cell fabrication, characterization and testing capabilities. Additional services include making modules and performing reliability testing. Core is designed with industrial compatibility in mind. Although fabrication on smaller substrates or even pieces is possible, the native substrate form factor is currently 156 mm silicon. New equipment is being selected to maintain compatibility with evolving solar manufacturing sizes (e.g., M12 = 295 mm diagonal). Supported technology thrusts reinforce industry relevance. Considering solely silicon technology, architectures researched include Al BSF, PERC, SHJ and various tandems, predominantly silicon-based with a perovskite top cell.

Facility supporting analytical needs for materials. Provides advanced facilities and equipment for materials characterization, surface, optical and structural analysis, elemental composition, and high-resolution electron microscopy. The center supports materials analysis across a broad range of scientific disciplines, including physics, chemistry, life sciences, earth and space sciences, environmental sciences, and engineering. Offers electron microscopy, X-ray diffraction, ICP-MS, spectroscopy, and related techniques.

The Biodesign Imaging Core (BIC) facility includes a Nikon C2 4-color laser, scanning confocal, a Nikon SIM E, super resolution, Structured Illumination Microscope, a wide-field fluorescence microscope, and an EVOS extended time-lapse live cell imaging system. The core specializes in live-cell imaging applications and includes cell culture capability. The core also has a 10-color, Gallios flow cytometry analyzer, and a 15 color FACS Aria IIU sorter.

The Flow Cytometry Core provides comprehensive cell analysis and sorting services using state-of-the-art instrumentation. Our analysis platforms include the BD LSRFortessa, BD FACSymphony A3, and Cytek Aurora, supporting high-parameter immunophenotyping and advanced single-cell analysis.
For cell sorting, we offer a 14-parameter, 4-laser Sony MA900 for high-speed, high-purity sorts, as well as a 16-parameter, 5-laser BD FACSAria dedicated to BSL-3 cell sorting. These platforms support a wide range of experimental needs, from basic workflows to complex, high-containment applications.