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University of Maryland School of Pharmacy Mass Spectrometry Center

University of Maryland School of Pharmacy

20 N Pine St

Mass Spectrometry Center

Baltimore, MD 21201

United States of America

https://www.pharmacy.umaryland.edu/centers/massspec/

Primary Contact:

Jeremy Doggett

Last Updated: 10/10/2016

Facility Details

The mission of the Mass Spectrometry Center in the Department of Pharmaceutical Sciences at the University of Maryland School of Pharmacy is to accelerate discovery by providing investigators, on campus and beyond, access to cutting edge technologies in mass spectrometry.

The Mass Spectrometry Center provides state-of-the-art expertise, methodology, and instrumentation to School of Pharmacy researchers and the surrounding research community. The center also provides researchers the opportunity to perform and access very sophisticated experiments by working in a true collaborative effort with faculty, students, and staff.

Other Facility Information

Expertise, Applications, and Services
The Mass Spectrometry Center is an Organized Research Center which provides a wide range of analytical capabilities through collaboration, self-service, fee-for-service, and educational relationships. We continue to develop new opportunities to enable internal investigators and external partners.

Metabolomics
• Discovery metabolomics
• Quantitative high-throughput metabolomics (Biocrates Absolute IDQ p180 panel)
• Targeted metabolomics

Lipidomics
• Discovery lipidomics
• Targeted lipidomics and lipid quantification
• Strucutral analysis and identification

Proteomics
• Peptide and protein identification
o Gel bands
o Immuno-precipitation (IP)
o Whole-cell, secreted, sub-cellular compartments, tissue digests
• Post-Translational Modifications (PTM)
• Chemically cross linked peptides
• Protein-drug adducts
• de novo peptide sequencing
• Top-down whole protein analysis

Hydrogen-Deuterium Exchange (HDX) MS
• Epitope mapping
• ID of drug binding sites/drug induced conformational changes
• Protein-protein interactions
• Aggregation, protein misfolding
• Effects of mutations or PTMs on protein structure and dynamics
• Structure or stability of biopharmaceuticals

Protein Footprinting
• Fast Photochemical Oxidation of Proteins (FPOP) coupled to high resolution MS
• Identification of protein-protein interactions

Metallomics and metal analysis
• Metal content identification and quantification

LC-MS/MS assay development
• Method transfer from literature
• Development of custom LC-MS/MS assays
• Validation according to FDA Guidance
• Visit our website for a list of developed assays

Drug analysis and PK/PD
• Analysis of drug compounds and metabolites
• PK/PD analysis and modeling
• GLP-regulated bioanalysis available
• Mass Spectrometry Imaging of drug distribution

GLP regulated bioanalysis for clinical studies
• Analysis according to Good Laboratory Practice (GLP) Regulations, 21 CFR Part 58
• QA/QC surveillance and compliance

Chemical compound ID and structure elucidation
• Molecular mass determination
• Accurate mass determination
• Structural analysis using a variety of fragmentation methodologies

Biomarker identification and characterization
• Discovery ‘Omics: metabolomics, lipidomics, and/or proteomics
• Mass Spectrometry Imaging for biomarker discovery or biomarker spatial localization
• Targeted metabolomics, targeted lipidomics
• Biomarker validation

Mass Spectrometry Imaging (MSI)
• Molecular histology for spatial localization of endogenous or exogenous molecules
• Biomarker discovery and characterization
• Drug Distribution

Bioinformatics
• Inquire about our variety of data processing, statistical analysis and pathway analysis options

Facility Policies

Services are offerred outside of University of Maryland School of Pharmacy

Consulting is offerred outside of University of Maryland School of Pharmacy