University of Maryland School of Pharmacy
20 N Pine St
Mass Spectrometry Center
Baltimore, MD 21201
United States of Americahttps://www.pharmacy.umaryland.edu/centers/massspec/Jeremy Doggett
Last Updated: 10/10/2016
The mission of the Mass Spectrometry Center in the Department of Pharmaceutical Sciences at the University of Maryland School of Pharmacy is to accelerate discovery by providing investigators, on campus and beyond, access to cutting edge technologies in mass spectrometry.
The Mass Spectrometry Center provides state-of-the-art expertise, methodology, and instrumentation to School of Pharmacy researchers and the surrounding research community. The center also provides researchers the opportunity to perform and access very sophisticated experiments by working in a true collaborative effort with faculty, students, and staff.
Expertise, Applications, and Services
The Mass Spectrometry Center is an Organized Research Center which provides a wide range of analytical capabilities through collaboration, self-service, fee-for-service, and educational relationships. We continue to develop new opportunities to enable internal investigators and external partners.
Metabolomics
• Discovery metabolomics
• Quantitative high-throughput metabolomics (Biocrates Absolute IDQ p180 panel)
• Targeted metabolomics
Lipidomics
• Discovery lipidomics
• Targeted lipidomics and lipid quantification
• Strucutral analysis and identification
Proteomics
• Peptide and protein identification
o Gel bands
o Immuno-precipitation (IP)
o Whole-cell, secreted, sub-cellular compartments, tissue digests
• Post-Translational Modifications (PTM)
• Chemically cross linked peptides
• Protein-drug adducts
• de novo peptide sequencing
• Top-down whole protein analysis
Hydrogen-Deuterium Exchange (HDX) MS
• Epitope mapping
• ID of drug binding sites/drug induced conformational changes
• Protein-protein interactions
• Aggregation, protein misfolding
• Effects of mutations or PTMs on protein structure and dynamics
• Structure or stability of biopharmaceuticals
Protein Footprinting
• Fast Photochemical Oxidation of Proteins (FPOP) coupled to high resolution MS
• Identification of protein-protein interactions
Metallomics and metal analysis
• Metal content identification and quantification
LC-MS/MS assay development
• Method transfer from literature
• Development of custom LC-MS/MS assays
• Validation according to FDA Guidance
• Visit our website for a list of developed assays
Drug analysis and PK/PD
• Analysis of drug compounds and metabolites
• PK/PD analysis and modeling
• GLP-regulated bioanalysis available
• Mass Spectrometry Imaging of drug distribution
GLP regulated bioanalysis for clinical studies
• Analysis according to Good Laboratory Practice (GLP) Regulations, 21 CFR Part 58
• QA/QC surveillance and compliance
Chemical compound ID and structure elucidation
• Molecular mass determination
• Accurate mass determination
• Structural analysis using a variety of fragmentation methodologies
Biomarker identification and characterization
• Discovery ‘Omics: metabolomics, lipidomics, and/or proteomics
• Mass Spectrometry Imaging for biomarker discovery or biomarker spatial localization
• Targeted metabolomics, targeted lipidomics
• Biomarker validation
Mass Spectrometry Imaging (MSI)
• Molecular histology for spatial localization of endogenous or exogenous molecules
• Biomarker discovery and characterization
• Drug Distribution
Bioinformatics
• Inquire about our variety of data processing, statistical analysis and pathway analysis options
Services are offerred outside of University of Maryland School of Pharmacy
Consulting is offerred outside of University of Maryland School of Pharmacy
