Other Facility Information

Expertise, Applications, and Services
The Mass Spectrometry Center is an Organized Research Center which provides a wide range of analytical capabilities through collaboration, self-service, fee-for-service, and educational relationships. We continue to develop new opportunities to enable internal investigators and external partners.

Metabolomics
• Discovery metabolomics
• Quantitative high-throughput metabolomics (Biocrates Absolute IDQ p180 panel)
• Targeted metabolomics

Lipidomics
• Discovery lipidomics
• Targeted lipidomics and lipid quantification
• Strucutral analysis and identification

Proteomics
• Peptide and protein identification
o Gel bands
o Immuno-precipitation (IP)
o Whole-cell, secreted, sub-cellular compartments, tissue digests
• Post-Translational Modifications (PTM)
• Chemically cross linked peptides
• Protein-drug adducts
• de novo peptide sequencing
• Top-down whole protein analysis

Hydrogen-Deuterium Exchange (HDX) MS
• Epitope mapping
• ID of drug binding sites/drug induced conformational changes
• Protein-protein interactions
• Aggregation, protein misfolding
• Effects of mutations or PTMs on protein structure and dynamics
• Structure or stability of biopharmaceuticals

Protein Footprinting
• Fast Photochemical Oxidation of Proteins (FPOP) coupled to high resolution MS
• Identification of protein-protein interactions

Metallomics and metal analysis
• Metal content identification and quantification

LC-MS/MS assay development
• Method transfer from literature
• Development of custom LC-MS/MS assays
• Validation according to FDA Guidance
• Visit our website for a list of developed assays

Drug analysis and PK/PD
• Analysis of drug compounds and metabolites
• PK/PD analysis and modeling
• GLP-regulated bioanalysis available
• Mass Spectrometry Imaging of drug distribution

GLP regulated bioanalysis for clinical studies
• Analysis according to Good Laboratory Practice (GLP) Regulations, 21 CFR Part 58
• QA/QC surveillance and compliance

Chemical compound ID and structure elucidation
• Molecular mass determination
• Accurate mass determination
• Structural analysis using a variety of fragmentation methodologies

Biomarker identification and characterization
• Discovery ‘Omics: metabolomics, lipidomics, and/or proteomics
• Mass Spectrometry Imaging for biomarker discovery or biomarker spatial localization
• Targeted metabolomics, targeted lipidomics
• Biomarker validation

Mass Spectrometry Imaging (MSI)
• Molecular histology for spatial localization of endogenous or exogenous molecules
• Biomarker discovery and characterization
• Drug Distribution

Bioinformatics
• Inquire about our variety of data processing, statistical analysis and pathway analysis options