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Gene Targeting & Transgenics Shared Resource

Roswell Park Cancer Institute

Roswell Park Cancer Institute

Elm & Carlton Streets

Buffalo, NY 14263

United States of America

https://www.roswellpark.edu/shared-resources/gene-targeting-and-transgenics

Primary Contact:

Aimee Stablewski

Last Updated: 10/01/2015

Facility Details

The Gene Targeting and Transgenic Resource (GTTR) enables investigators to modify the murine genome for the systematic dissection of the genetic, molecular, cellular and physiological mechanisms underlying complex biological processes.

Traditionally, this has been done by creation of transgenics through pronuclear microinjection and knocking out or knocking in genes via mouse ES cell technologies.

This is no longer the case given the recent advances of genome-editing tools such as ZFNs, TALENs and most recently CRISPR/Cas, which allow for a targeted approach by injection directly into the embryo.

In general, these methods are proving to be faster and more efficient than traditional means.

In addition, the core also provides investigators with mouse reproductive services such as cryopreservation of valuable mouse strains and IVF (in vitro fertilization) to aid in mouse cohort generation, especially when faced with increasing complex genotype demands.

Facility Policies

Services are offerred outside of Roswell Park Cancer Institute

Consulting is not offerred outside of Roswell Park Cancer Institute