The Charité Experimental MRI laboratories at Charité Campus Mitte offer two 7 Tesla Bruker MRI machines for preclinical research. Users have access to a wide range of established methods in the field of neuroimaging of anatomy, tissue microstructure, structural/functional connectivity, but also in the field of functional and molecular MRI of tumors, kidney, placenta or heart.

Preclinical (mice, rats) Radionuclide Imaging with SPECT/CT and PET/MR, radiochemistry, tracer biokinetics and kinetic modeling

Transgenic Service providing
• Generation of transgenic mice via pronucleus injection (TALEN, CrispR Cas9) and ES-cell based techniques including ES-cell culture
• Cryopreservation of mice via Sperm and Embryos
• Rederivation
• De novo ES-cell establishment
• De novo establishment of Trophoblast cells

We are generating viral vectors for Charite members and external non-profit academic institutions.

The Core Facility offers thin sectioning, transmission electron microscopy (TEM), Cryo-TEM, confocal light microscopy and scanning electron microscopy (SEM). Advice is given routinely for adequate project programming. Projects are closely monitored during the course of evaluations by the core facility staff. The core facility is equipped with the necessary LM, TEM and SEM devices and a technical staff takes care of all the technical work. The director (Prof. Bachmann), vice director (Prof. Vida) and an additional technical assistant plus a photographer help to extend and control project work in the core facility.