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MicroCT Imaging Facility

University of Connecticut Health Center

New England Musculoskeletal Institute

Department of Orthopaedic Surgery

Farmington, CT 06034-4037

United States of America

http://researchit.uchc.edu/resources/microct_imaging.html

Last Updated: 03/01/2012

Facility Details

The UConn Health Center MicroCT Imaging Facility provides core services of three-dimensional imaging and quantitation of tissue structure using high-resolution X-ray computed microtomography (microCT). Resolution of structural features below 10 um allows for accurate and precise evaluation of trabecular and cortical bone architecture, density, and porosity of bones from mice, including femora, tibiae, vertebrae, humeri, ulnae, calvaria, mandibles, teeth, and ectopic bone formation. Data obtained from microCT analyses are helpful toward identifying and quantitating definitive phenotypes in transgenic and knockout mouse models, as well as the skeletal effects of hormonal deficiency (e.g., ovariectomy) and pharmaceutical agents. Hydroxyapatite-phantom calibrated measurements of true volumetric density (mg/cm^3) provide accurate measurements of mineralization shifts in these animal models, complementing rapid imaging modalities afforded by micro-DXA (Piximus) and radiography (Faxitron), which are also available.

Other Facility Information

Expertise in mechanical testing across a wide range of length scales.
Conduct animal studies involving musculoskeletal procedures (bone fracture, tissue defect repair, tissue engineering implants, loading models of bone and cartilage, soft tissue injury)

Facility Policies

Services are offerred outside of University of Connecticut Health Center