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University of North Dakota
501 N Columbia Rd
University of North Dakota, School of Medicine, Room 3570
Grand Forks, ND 58202
http://www.med.und.edu/cobre/mass_spec/index.htmlDr. Golovko
Last Updated: 10/14/2011
Quantitative Analysis of Small Molecules by UPLC or HPLC Coupled with Tandem Mass Spectrometry
*Bioactive lipids
-Prostaglandin profiling (COX products)
-Products of lipid peroxidation (isoprostanes)
-Hydroxy-Fatty Acids profiling including resolvins (LOX and P450 products)
*Hydroxycholesterol quantification
*Carbohydrates
*Nucleotides and nucleosides (adenosine, DNA modifications)
*Lipid profiling
*HNE (products of fatty acid peroxidation)
Qualitative Analysis of Small Molecules by Direct Infusion or UPLC Analysis Coupled with Tandem Mass Spectrometry
*Structure and elemental composition prediction using high resolution accurate mass analysis
Metabolomics (comparison of metabolites between different experimental groups e.g. wild-type and genetically modified, control and treated)
Drug Metabolism (determination of molecule biotransformations)
Qualitative and Quantitative Analysis of Small Volatile Molecules Using GC/MS with Various Ionizations techniques, e.g., EI, NICI, CI.
Fatty acid analysis
Services are offerred outside of University of North Dakota
Synapt G2 HD Q-TOF Mass Spectrometer with Ion Mobility Technology with UPLC Waters Aquity system (Waters)
*High resolution (40,000) accurate mass (2 ppm) instrument with ESI, APCI, APPI, Solid Probe ion sources, ion mobility cell, and TriVersa NanoMate
Allows for MS and MSe analysis, exact mass, elemental composition, and structure determination of unknown compounds
Metabolomics profiling and experimental group metabolome comparision
API 3000 Triple Quadrupole Mass Spectrometer (Applied Biosystems-Sciex) coupled to Agilent 1100 HPLC
*High sensitivity, low-resolution instrument with ESI and APCI ion sources
Allows for a targeted quantification of known compounds using LC-MS/MS approach
Available for self operation after training.
Polaris Q Trap Mass Spectrometer coupled to TRACE GC Ultra (ThermoFinigan)
*Low-Resolution, EI and CI, GC-MS and GC-MS/MSn
Allows for quantification of volatile compounds, often requires derivatization
Available for self operation after training.
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Facility Details
About This Facility
Services and Equipment
Publications
Associations
