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Mass Spectrometry for Small Molecules

University of North Dakota

501 N Columbia Rd

University of North Dakota, School of Medicine, Room 3570

Grand Forks, ND 58202

United States of America

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Primary Contact:

Dr. Golovko

Last Updated: 10/14/2011

Facility Details

Quantitative Analysis of Small Molecules by UPLC or HPLC Coupled with Tandem Mass Spectrometry
*Bioactive lipids
-Prostaglandin profiling (COX products)
-Products of lipid peroxidation (isoprostanes)
-Hydroxy-Fatty Acids profiling including resolvins (LOX and P450 products)
*Hydroxycholesterol quantification
*Nucleotides and nucleosides (adenosine, DNA modifications)
*Lipid profiling
*HNE (products of fatty acid peroxidation)

Qualitative Analysis of Small Molecules by Direct Infusion or UPLC Analysis Coupled with Tandem Mass Spectrometry
*Structure and elemental composition prediction using high resolution accurate mass analysis

Metabolomics (comparison of metabolites between different experimental groups e.g. wild-type and genetically modified, control and treated)

Drug Metabolism (determination of molecule biotransformations)

Qualitative and Quantitative Analysis of Small Volatile Molecules Using GC/MS with Various Ionizations techniques, e.g., EI, NICI, CI.
Fatty acid analysis

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